Evaluating healing after root-end surgery using L-PRF
Evaluation of Periapical Healing Following Endodontic Microsurgery With Leukocyte and Platelet Rich Fibrin (L-PRF)
University of Pennsylvania · NCT06545084
This study tests if using a special treatment called L-PRF during root-end surgery can help patients with ongoing tooth problems heal better and faster.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Pennsylvania (other) |
| Locations | 1 site (Philadelphia, Pennsylvania) |
| Trial ID | NCT06545084 on ClinicalTrials.gov |
What this trial studies
This study evaluates the healing of periapical tissues following endodontic microsurgery with the application of Leukocyte and Platelet Rich Fibrin (L-PRF). Patients diagnosed with persistent periapical pathology and scheduled for surgery at the University of Pennsylvania will have the option to receive L-PRF to enhance bone formation at the surgical site. Healing will be monitored through clinical and radiographic assessments at intervals of six, twelve, eighteen, and twenty-four months post-surgery.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old with persistent endodontic periapical pathology and in good general health.
Not a fit: Patients with suspected root fractures or those classified as ASA 3 or greater will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could improve healing outcomes for patients undergoing endodontic microsurgery.
How similar studies have performed: While the use of L-PRF in dental procedures is gaining interest, this specific application in endodontic microsurgery is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Provision of signed and dated informed consent form. 2. Stated willingness to comply with all study procedures and availability for the duration of the study, including the follow-up visits. 3. Male or Female age \>18 years old. 4. In good general health (ASA 2 or less) with no contraindications for Endodontic Microsurgery. 5. Persistent endodontic periapical pathology Class A, B, or C according to the Kim and Kratchman classification (5) 6. Intact coronal restorations with no evidence of leakage or caries under the restoration. Exclusion Criteria: 1. Minors. 2. Suspected root fractures. 3. ASA classification 3 or greater. 4. Periapical pathology Class D, E, or F according to the Kim and Kratchman classification (5). 5. Patients with history of Oral or IV Bisphosphonate use. 6. Patients may be excluded if their treatment team do not believe Endodontic microsurgery and L-PRF graft is in the patient's best interests.
Where this trial is running
Philadelphia, Pennsylvania
- Penn Dental Medicine — Philadelphia, Pennsylvania, United States (RECRUITING)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Apical Periodontitis