Imaging inflammation in abdominal aortic aneurysm using a PET tracer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study uses a novel radiotracer with PET/CT to visualize inflammation in the aorta of adults with abdominal aortic aneurysm. Participants will undergo baseline PET/CT with 64Cu-DOTA-ECL1i and a follow-up scan about 6-8 weeks later to assess consistency of tracer uptake and the effect of clinical changes on imaging. The goal is to understand whether this molecular imaging approach can reflect inflammatory activity linked to aneurysm biology. The study is conducted at Penn Medicine under institutional guidelines and is not designed as a therapeutic intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Participants will be at least 18 years of age
2. Have an established diagnosis of abdominal aortic aneurysm based on standard clinical criteria or are an age matched control with absence of known AAA.
3. Participants must be informed of the investigational nature of this study and be willing to provide written informed consent and participate in this study in accordance with institutional and federal guidelines prior to study-specific procedures.

Exclusion Criteria:

1. Females who are pregnant or breast feeding at the time of the PET/CT scan will not be eligible for this study; a urine pregnancy test will be performed in women of child-bearing potential before the injection of radiotracer.
2. Inability to tolerate imaging procedures in the opinion of an investigator or treating physician
3. Patients with chronic renal disease whose GFR is less than 40 mL/min/1.73m² at the time of enrollment.
4. Documented allergy to iodinated contrast
5. Any current medical condition, illness, or disorder as assessed by medical record review and/or self-reported that is considered by a physician investigator to be a condition that could compromise participant safety or successful participation in the study
6. Less than 6 months life expectancy as deemed by the treating physician at the time of initial enrollment.

Where it's running

• Penn Medicine; Perelman School of Medicine
  Philadelphia, Pennsylvania, United States Recruiting

Study contacts

• Principal investigator: Scott M Damrauer, MD — Penn Medicine Division of Vascular Surgery
• Study coordinator: Erin Schubert
• Email: erin.schubert@pennmedicine.upenn.edu
• Phone: 215-573-6569

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.