Early General Anesthesia to See if it Reduces PTSD After Cesarean Delivery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a small randomized pilot trial comparing two current care approaches for managing intraoperative pain during cesarean delivery performed with neuraxial anesthesia. Eligible participants are women who experience severe pain despite first-line treatments and are non-emergent cases at a single center. They will be assigned to either early conversion to general anesthesia or a limited IV sedation trial with possible later conversion to general anesthesia. Outcomes will be measured during hospitalization and up to six weeks postpartum to assess mental health, medical status, and recovery quality.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women aged 18 or older undergoing non-emergent cesarean delivery with primary neuraxial (epidural, spinal, or CSE) anesthesia. Eligible patients will be those who report severe pain during surgery, defined as pain that does not resolve with 2 trials of first-line pharmacologic therapies (e.g., epidural supplementation with local anesthetics; intravenous opioid analgesics).

Exclusion Criteria:

* We will exclude patients who require induction of general anesthesia prior to umbilical cord clamping and by clinician determination.

Where it's running

• Hospital of the University of Pennsylvania
  Philadelphia, Pennsylvania, United States Recruiting

Study contacts

• Study coordinator: Mark Neuman, MD
• Email: eagletadmin@pennmedicine.upenn.edu
• Phone: 215-746-7468

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.