Longitudinal investigation of central nervous system vasculitis
Official title: Longitudinal Study for Central Nervous System Vasculitis
Run by University of Pennsylvania · NCT05734404 · Data updated 2026-11-12
This study is trying to learn more about primary central nervous system vasculitis by following patients over three years to see how the disease affects them and to find better ways to measure its activity and outlook.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | University of Pennsylvania Academic / other |
| Locations | 6 sites (Rochester, Minnesota and 5 other locations) |
| Status | Recruiting |
| Started | March 1, 2023 |
| Main results expected | December 31, 2030 |
| Study ends | December 31, 2030 |
| Registry record updated | January 23, 2026 |
| Trial ID | NCT05734404 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older who meet the diagnostic criteria for CNSV and have an unexplained neurologic deficit.
✕Probably not a fit
Patients who do not have CNSV or those with systemic vasculitis that could explain their symptoms may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to establish a research cohort for primary central nervous system vasculitis (CNSV), a rare and potentially fatal condition that can lead to severe neurological complications. Participants will undergo study visits every three months for the first year and annually for two additional years, during which blood samples will be collected and physical exams conducted. The study seeks to enhance understanding of the disease's natural history, pathophysiology, and potential biomarkers for assessing disease activity and prognosis. By utilizing a multicenter approach, the research aims to overcome previous limitations associated with small patient numbers and lack of comprehensive investigations.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of central nervous system vasculitis, potentially enhancing patient outcomes.
How similar studies have gone: While research on CNSV has been limited, the multicenter approach in this study may provide new insights that have not been previously explored in similar studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: i. Diagnostic criteria for CNSV 1. The presence of an acquired and otherwise unexplained neurologic deficit 2. The presence of either classic angiographic or histopathologic features of angiitis in the CNS 3. No evidence of systemic vasculitis or any condition that could cause the angiographic or pathologic features ii. ≥18 years of age Exclusion Criteria: i. Unwilling to sign informed consent.
Where it's running
-
Mayo Clinic
Rochester, Minnesota, United States Recruiting -
Cleveland Clinic
Cleveland, Ohio, United States Recruiting -
University of Pennsylvania
Philadelphia, Pennsylvania, United States Recruiting -
Vanderbilt University
Nashville, Tennessee, United States Recruiting -
St. Joseph's Healthcare
Hamilton, Canada Recruiting -
University of Toronto/Sinai Health
Toronto, Canada Recruiting
Study contacts
- Principal investigator: Rula Hajj-Ali, MD — The Cleveland Clinic
- Study coordinator: Carol McAlear
- Email: cmcalear@upenn.edu
- Phone: 7813214567
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.