Clinical trial Recruiting at 1 site Observational

Observational study on relapsing polychondritis

Official title: Longitudinal Study for Relapsing Polychondritis

Run by University of Pennsylvania · NCT04919538 · Data updated 2026-11-12

This study is looking to learn more about relapsing polychondritis by regularly checking in with participants to see how the disease affects them and to find better ways to diagnose and treat it.

Quick facts

Study typeObservational
SexAll
Enrollment100 (estimated)
SponsorUniversity of Pennsylvania
Academic / other
Locations1 site (Philadelphia, Pennsylvania)
StatusRecruiting
StartedFebruary 26, 2021
Main results expectedJanuary 2030
Study endsJanuary 2030
Registry record updatedJanuary 23, 2026
Trial IDNCT04919538 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are individuals diagnosed with relapsing polychondritis.

Probably not a fit

Patients who are unable to provide consent or are minors may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on relapsing polychondritis (RP), a rare systemic inflammatory disease that causes recurrent inflammation of cartilage and can affect various organ systems. The research aims to understand the pathogenesis of RP through a longitudinal cohort approach, involving regular study visits every six months or annually. Participants will undergo blood and urine collection, physical exams, and complete questionnaires to assess disease activity and health status, which will help generate insights into the disease's mechanisms and potential new diagnostic and treatment strategies.

Why it matters

Potential benefit: If successful, this study could lead to improved diagnostic and treatment strategies for patients with relapsing polychondritis.

How similar studies have gone: While the approach is novel in its longitudinal and multicenter design, similar studies have shown promise in understanding rare diseases.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* 1\. Any subject considered to have a diagnosis of relapsing polychondritis according to the investigator.

Exclusion Criteria:

* 1\. Inability to provide consent, or in the case of minors, assent.

Where it's running

  • University of Pennsylvania
    Philadelphia, Pennsylvania, United States
    Recruiting

Study contacts

  • Principal investigator: Shubhasree Banerjee, MD — University of Pennsylvania
  • Study coordinator: Carol McAlear
  • Email: cmcalear@upenn.edu
  • Phone: 7813214567

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  • Comparing five immunomodulatory treatments for relapsing polychondritis

    This project will try commonly used immune-suppressing medicines to see which best controls mild-to-moderate relapsing polychondritis.

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.