Observational study on relapsing polychondritis
Official title: Longitudinal Study for Relapsing Polychondritis
Run by University of Pennsylvania · NCT04919538 · Data updated 2026-11-12
This study is looking to learn more about relapsing polychondritis by regularly checking in with participants to see how the disease affects them and to find better ways to diagnose and treat it.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | University of Pennsylvania Academic / other |
| Locations | 1 site (Philadelphia, Pennsylvania) |
| Status | Recruiting |
| Started | February 26, 2021 |
| Main results expected | January 2030 |
| Study ends | January 2030 |
| Registry record updated | January 23, 2026 |
| Trial ID | NCT04919538 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals diagnosed with relapsing polychondritis.
✕Probably not a fit
Patients who are unable to provide consent or are minors may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study focuses on relapsing polychondritis (RP), a rare systemic inflammatory disease that causes recurrent inflammation of cartilage and can affect various organ systems. The research aims to understand the pathogenesis of RP through a longitudinal cohort approach, involving regular study visits every six months or annually. Participants will undergo blood and urine collection, physical exams, and complete questionnaires to assess disease activity and health status, which will help generate insights into the disease's mechanisms and potential new diagnostic and treatment strategies.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic and treatment strategies for patients with relapsing polychondritis.
How similar studies have gone: While the approach is novel in its longitudinal and multicenter design, similar studies have shown promise in understanding rare diseases.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 1\. Any subject considered to have a diagnosis of relapsing polychondritis according to the investigator. Exclusion Criteria: * 1\. Inability to provide consent, or in the case of minors, assent.
Where it's running
-
University of Pennsylvania
Philadelphia, Pennsylvania, United States Recruiting
Study contacts
- Principal investigator: Shubhasree Banerjee, MD — University of Pennsylvania
- Study coordinator: Carol McAlear
- Email: cmcalear@upenn.edu
- Phone: 7813214567
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Ocular Symptoms in ANCA-Associated Vasculitis
This study tests ocular changes in adults with GPA, MPA, or related vasculitis to see how the eyes are involved.
-
Systemic Vasculitis Prognosis and Outcome
This study follows patients suspected or diagnosed with systemic vasculitis over 10 years to see how their disease progresses and what factors predict outcomes.
-
Reducing unnecessary medications in older adults with rheumatic conditions
This project will test whether giving doctors individualized MedSafer reports plus patient EMPOWER brochures helps people 60+ with rheumatic conditions who take five or more regular medications stop or reduce risky medicines.
-
Comparing five immunomodulatory treatments for relapsing polychondritis
This project will try commonly used immune-suppressing medicines to see which best controls mild-to-moderate relapsing polychondritis.
-
Evaluating Upadacitinib for treating relapsing polychondritis
This study is testing if a new medication called Upadacitinib can help adults with relapsing polychondritis feel better compared to standard treatments like steroids and immunosuppressants.
-
Inventory of vocal cord lesions causing dysphonia in autoimmune disease patients
This study looks at the types of vocal cord problems that cause voice issues in people with autoimmune diseases to help improve their diagnosis and treatment.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.