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Clinical trials and research at Hospices Civils de Lyon

• 264Clinical trials
• 8Countries

Newest trials

All recruiting trials (newest 150 of 264)

• Blood viscosity in ARDS: a look at how thick the blood is

  This study tests whether blood viscosity is higher in adults with ARDS and whether viscosity relates to their breathing and blood flow issues.

  Recruiting Hospices Civils de Lyon · Lyon · NCT07823296

• Virus interactions in hospitalized patients during winter seasons in Lyon

  This study tests all virological results from hospitalized patients in Lyon during winter to see how different respiratory viruses may co-occur or exclude each other.

  Recruiting Hospices Civils de Lyon · Lyon, Rhone · NCT07805590

• Surgical Use of Efanoctocog alfa in Hemophilia A Patients

  This observational study looks at how efanesoctocog alfa (Altuvoct) is used around surgery in people with hemophilia A to see if it helps control bleeding.

  Recruiting Hospices Civils de Lyon · Bron · NCT07723560

• Sleep quality and its determinants during the liver transplant pathway

  This study tests how sleep quality changes from before liver transplantation to six months after, in adults on the transplant waitlist at a single hospital.

  Recruiting Hospices Civils de Lyon · Lyon · NCT07674355

• Compare Trans-Stomal Bladder Lithotripsy Methods in Continent Catheterizable Urinary Reservoirs

  This study looks at different ways to break up bladder stones in people with continent catheterizable urinary diversions to see which method works best when the normal route isn’t available.

  Recruiting at 2 sites Hospices Civils de Lyon · Lyon and 1 other locations · NCT07643454

• French version validation of the New Mobility Score for older adults after hip fracture

  This study tests whether the French version of the New Mobility Score accurately measures mobility in French patients aged 75 and older after hip fracture.

  Recruiting Hospices Civils de Lyon · Lyon · NCT07622095

• Understanding rare autoinflammatory diseases and their key features

  This study aims to see what genes and characteristics are linked to rare autoinflammatory diseases in adults and young people treated at a Lyon hospital.

  Recruiting Hospices Civils de Lyon · Lyon · NCT07622069

• Nervous system study: sleep, seizures, and dreams in epilepsy with brain stimulation

  This study tests whether direct brain stimulation during sleep can influence nocturnal seizures and interictal discharges in adults with drug-resistant focal epilepsy undergoing SEEG.

  Recruiting Hospices Civils de Lyon · Durham, North Carolina and 1 other locations · NCT07605858

• Type I interferon response in the nose during respiratory viral infections in older adults

  This study tests whether a nasal Type I interferon score can help identify respiratory viral infections in older adults already diagnosed by standard tests in a geriatric ward.

  Recruiting Hospices Civils de Lyon · Lyon · NCT07601412

• Intracranial Mapping of Cortical Control of Breathing in Epilepsy

  This study tests whether targeted brain area activity during SEEG can reveal how the cortex helps regulate breathing in people with drug-resistant epilepsy.

  Recruiting Hospices Civils de Lyon · Bron, Rhone · NCT07599150

• Understanding the noradrenergic system in aging and Parkinson’s

  Researchers will use a new brain tracer and PET/MRI to see how the noradrenergic system behaves in healthy aging and in Parkinson’s disease, and whether these changes relate to cognitive, motor, or smell abilities.

  Recruiting Hospices Civils de Lyon · Bron · NCT07569120

• BOUGIE CAP dilation for short benign esophageal strictures

  This research will test whether the BOUGIE CAP device can safely and effectively widen short benign esophageal strictures in adults who have trouble swallowing.

  Recruiting Hospices Civils de Lyon · Lyon · NCT07534800

• Feasibility of using a weight-adjusted saline bolus with electrical impedance tomography to map lung perfusion in children

  This pediatric pilot tests whether a carefully dosed saline bolus with electrical impedance tomography can map lung perfusion and ventilation distribution in kids with acute respiratory failure.

  Recruiting Hospices Civils de Lyon · Bron, France · NCT07532811

• Peer-support breastfeeding program for mothers facing severe socioeconomic hardship

  This project will try a peer-support breastfeeding program to help mothers in severe socioeconomic deprivation who plan to breastfeed their hospitalized infants.

  Recruiting Hospices Civils de Lyon · Bron, France · NCT07499466

• Understanding 7q11.23 Microduplication Syndrome (7DUP) and Related Neurodevelopmental Conditions

  This study tests how 7q11.23 microduplication affects development in people over 5 and under 50, compared with matched controls.

  Recruiting at 2 sites Hospices Civils de Lyon · Bron and 1 other locations · NCT07469566

• Using [18F]FET PET to find ACTH-secreting pituitary microadenomas

  This project tests whether [18F]FET PET scans can better locate ACTH-secreting pituitary microadenomas in adults with Cushing's disease.

  Recruiting Hospices Civils de Lyon · Bron · NCT07463625

• Trust in people with intellectual disability: a look at Down syndrome and Fragile X syndrome

  This study tests how people with Down syndrome or Fragile X syndrome process trust in social interactions to see how trust decisions differ in these groups.

  Recruiting Hospices Civils de Lyon · Bron · NCT07434037

• Caregiver support at different stages of Alzheimer's disease

  This project uses questionnaires to see how family caregivers help people aged 60 and older with Alzheimer's disease at different stages and what that care costs.

  Recruiting Hospices Civils de Lyon · Villeurbanne · NCT07409506

• Nerve and heart activity in hepatocellular carcinoma (HCC)

  This project will test whether measuring autonomic nervous system signals—such as heart rate patterns, sensory‑response tests, and liver biopsy markers—can help detect or better characterize HCC in adults with compensated cirrhosis who are having a liver biopsy.

  Recruiting Hospices Civils de Lyon · Lyon · NCT07393074

• Boosting prevention during GP visits with brief healthy-conversation skills

  This project will see if training GPs in short 'healthy conversation' techniques helps adults who are sedentary or have suboptimal diets to start being more active and eat healthier.

  Recruiting at 4 sites Hospices Civils de Lyon · Beynost and 3 other locations · NCT07391462

• How medicines are managed during targeted radioligand cancer treatment

  This project tracks how pharmacists and nuclear medicine teams manage medications and provide pharmaceutical advice for adults receiving targeted radioligand treatments like Lutathera and Pluvicto.

  Recruiting Hospices Civils de Lyon · Bron and 2 other locations · NCT07389512

• Second cohort following patients entering a multidisciplinary care pathway for post-COVID syndromes (SyPoCo2)

  This project will test whether linking long COVID patients' symptoms with blood immune and molecular markers can find biomarkers and possible treatment targets.

  Recruiting at 2 sites Hospices Civils de Lyon · Pierre-Bénite and 1 other locations · NCT07356570

• Parental training to reduce newborn exposure to endocrine disruptors.

  This project will test whether giving parents simple training can lower newborns' urinary levels of short-lived endocrine disruptors like phthalates.

  Recruiting Hospices Civils de Lyon · Bron · NCT07349927

• Cystinosis and Mitochondrial Metabolism study

  This study tests a treatment approach targeting mitochondrial metabolism in people with nephropathic cystinosis to see if it improves kidney-related outcomes.

  Recruiting at 9 sites Hospices Civils de Lyon · Bron and 8 other locations · NCT07319091

• Gut microbiota–derived amino acid metabolites in MASLD/MASH

  This study tests whether gut microbiota–produced amino acid metabolites are linked to MASLD/MASH in adults by collecting stool, blood, and urine samples and analyzing dietary factors.

  Recruiting Hospices Civils de Lyon · Pierre-Bénite · NCT07313007

• Adding local muscle vibration to rehabilitation for older adults after hip fracture

  This project will test whether adding local muscle vibration to standard rehabilitation helps people aged 75 and older recover after hip fracture surgery.

  Recruiting Hospices Civils de Lyon · Lyon · NCT07309965

• How Trikafta (elexacaftor‑tezacaftor‑ivacaftor) is handled by children’s bodies with cystic fibrosis

  This project will test how Trikafta (elexacaftor‑tezacaftor‑ivacaftor) is absorbed, distributed, metabolized, and eliminated in children aged 2–17 with cystic fibrosis.

  Recruiting Hospices Civils de Lyon · Bron · NCT07303621

• Patient quality of life after different glaucoma surgeries

  This project uses the NEI-VFQ-25 vision questionnaire to see if adults who have PreserFlo MicroShunt, trabeculectomy, or non-penetrating deep sclerectomy report different quality of life after surgery.

  Recruiting Hospices Civils de Lyon · Lyon · NCT07303257

• See if suicidal behavior in kids during the Covid-19 period in the Auvergne-Rhone-Alpes region changed

  This study tests how common suicidal thoughts or actions were among children and teens in the Auvergne-Rhône-Alpes region during the COVID-19 period, using data from emergency departments and hospital records.

  Recruiting Hospices Civils de Lyon · Bron and 3 other locations · NCT07302295

• Early Adapted Physical Activity to Prevent and Manage AI-induced Musculoskeletal Pain in Breast Cancer

  This trial tests whether starting a personalized adapted physical activity program at the start of aromatase inhibitor therapy can reduce musculoskeletal pain for postmenopausal breast cancer patients.

  Recruiting Hospices Civils de Lyon · Lyon and 1 other locations · NCT07295457

• Measuring tongue muscle function in children with obstructive sleep apnea

  This project tests tongue strength and movement in children with suspected obstructive sleep apnea to see if tongue function contributes to breathing problems during sleep.

  Recruiting Hospices Civils de Lyon · Bron · NCT07273019

• Patient-centered clinical decision support for recommended screenings in primary care

  This project will test a patient-centered computer tool that helps adults aged 18–74 and their primary care doctors identify which preventive screenings are recommended and support shared decision-making.

  Recruiting at 12 sites Hospices Civils de Lyon · Belley and 19 other locations · NCT07270926

• A gut-microbiota–friendly diet after bariatric surgery to help eating habits and taste

  This tests whether a diet designed to increase gut microbiota diversity helps adults who have had sleeve gastrectomy or Roux-en-Y gastric bypass keep weight off, change food preferences and taste/smell, and improve gut-related health compared with standard nutrition counseling.

  Recruiting Hospices Civils de Lyon · Lyon and 2 other locations · NCT07268508

• Biomechanical effects of unequal lower limb length in children

  This project will use low-dose biplanar X-rays (EOS) and synchronized force plates to see if anatomical leg-length differences in 10–15-year-olds change loads on the hips and lower spine.

  Recruiting Hospices Civils de Lyon · Bron · NCT07254351

• Metabolite patterns in blood and urine of people with fibrosing interstitial lung disease and precapillary pulmonary hypertension

  We will see if blood and urine metabolite patterns change in people with fibrosing interstitial lung disease who have precapillary pulmonary hypertension, before and during treatments such as inhaled treprostinil.

  Recruiting Hospices Civils de Lyon · Bron, Rhone · NCT07254338

• Home-based intensive motor telerehabilitation with MindMotion GO for post-stroke arm weakness

  This will test whether a 12-week home telerehabilitation program using the MindMotion GO device improves arm motor recovery in people after a stroke.

  Recruiting Hospices Civils de Lyon · Saint-Genis-Laval, Lyon · NCT07254195

• Brain networks that drive motivation

  This study will try different non-invasive brain stimulation methods in healthy adults (18-40) to see if changing connectivity between frontal, striatal, noradrenergic, and motor circuits alters willingness to exert effort for rewards.

  Recruiting Hospices Civils de Lyon · Bron · NCT07251816

• Impact of the brain’s adenosine pathway on epilepsy and arousal in adults

  This study tests how the brain’s adenosine system affects arousal and breathing in adults with drug-resistant focal epilepsy compared with healthy volunteers.

  Recruiting Hospices Civils de Lyon · Bron · NCT07249034

• Interferon reference for older people (REFIPA)

  This project will test whether measuring type I interferon responses can help identify active respiratory virus infections in people aged 80 and over.

  Recruiting Hospices Civils de Lyon · Villeurbanne · NCT07239830

• Probiotic Support for GLP-1 RA Weight Loss in Obesity

  This study tests whether adding probiotics helps people starting GLP-1 receptor agonist treatment for obesity see if they tolerate the medication better and possibly lose more weight.

  Recruiting Hospices Civils de Lyon · Pierre-Bénite · NCT07213323

• Food preference assessment for older patients in geriatric wards

  We will try a short, adapted questionnaire to capture food preferences in people over 70 hospitalized in geriatric units who may have swallowing problems.

  Recruiting Hospices Civils de Lyon · Lyon and 2 other locations · NCT07205354

• Orofacial function and sleep breathing in infants with Down syndrome

  This study will test whether measures of mouth and facial muscle function and a non‑nutritive sucking recording at six months can help detect sleep apnea in infants with Down syndrome.

  Recruiting Hospices Civils de Lyon · Bron · NCT07195253

• Long-term effects of NMDAR encephalitis

  This project will use online questionnaires to see if adults who had anti-NMDAR encephalitis experience lasting social, cognitive, or psychological problems.

  Recruiting Hospices Civils de Lyon · Bron · NCT07158229

• Immune suppression after Whipple (pancreaticoduodenectomy)

  This will test whether measuring patients' immune function (mHLA-DR) after a Whipple operation for a pancreatic head tumor can identify people at higher risk of serious infections or pancreatic complications.

  Recruiting Hospices Civils de Lyon · Lyon and 3 other locations · NCT07144917

• French version of the OSA-18 questionnaire validation

  This study tests whether a French version of the OSA-18 questionnaire is valid for measuring pediatric obstructive sleep apnea symptoms and their impact as reported by caregivers.

  Recruiting Hospices Civils de Lyon · Bron, Rhône · NCT07136909

• Medium-term outcomes of treatments for antibody-associated autoimmune encephalitis

  This project will try three common initial treatment approaches — first-line therapy alone, first-line plus rituximab, or first-line with dual immunosuppression — in adults and children with antibody-associated autoimmune encephalitis to see which leads to better medium-term recovery.

  Recruiting Hospices Civils de Lyon · Bron · NCT07133113

• How iron affects the immune system in HHT

  This study will test whether giving iron changes T-cell counts and other immune markers in adults with HHT.

  Recruiting Hospices Civils de Lyon · Bron, Rhone · NCT07111598

• Monitoring anti‑TFPI antibodies in adult men with severe hemophilia

  This project tests blood-based lab methods to monitor anti-TFPI antibodies in adult men with severe hemophilia who are on prophylaxis.

  Recruiting Hospices Civils de Lyon · Bron and 1 other locations · NCT07101926

• Autonomous nurse-led methadone delivery

  This test sees if allowing nurses to manage and give methadone helps people starting treatment for opioid use disorder.

  Recruiting at 4 sites Hospices Civils de Lyon · Bayonne and 7 other locations · NCT07085377

• Cutaneous resonance stimulation to reduce preoperative anxiety in cardiac surgery patients

  This pilot will test whether gentle skin stimulation called cutaneous resonance stimulation can shift autonomic balance and lower anxiety in adults scheduled for elective cardiac surgery with extracorporeal circulation.

  Recruiting Hospices Civils de Lyon · Bron · NCT07070986

• MORC2 gene changes and how they relate to nerve and developmental symptoms

  This project will try to see if specific changes in the MORC2 gene explain why some people develop Charcot–Marie–Tooth nerve problems while others have broader developmental delays, growth impairment, facial differences, and neuropathy.

  Recruiting at 12 sites Hospices Civils de Lyon · Besançon and 11 other locations · NCT07038239

• Mobile low-dose CT lung cancer screening program

  This project will try using a CT-equipped mobile unit versus a hospital screening unit to screen people aged 50–74 with a heavy smoking history.

  Recruiting at 2 sites Hospices Civils de Lyon · Pierre-Bénite and 1 other locations · NCT07015151

• PET‑MRI mapping of brainstem serotonin pathways in adults with Dravet syndrome

  This uses a PET‑MRI scan with the tracer [18F]MPPF to see if serotonin pathways in the brainstem differ in adults with Dravet syndrome compared with healthy controls.

  Recruiting Hospices Civils de Lyon · Bron, Rhone · NCT07013331

• Calcium Isotope Ratios in Kids on Dialysis Receiving Cinacalcet

  This study tests how calcium isotope ratios relate to bone balance in children aged 3–17 who are on dialysis and starting cinacalcet for secondary hyperparathyroidism.

  Recruiting at 7 sites Hospices Civils de Lyon · Bordeaux and 6 other locations · NCT07007338

• What patients and rehab teams think about advanced rehabilitation technologies after stroke

  This project will see what post-stroke patients, rehabilitation physicians, and allied health professionals think about using technologies like exoskeletons, social robots, wearables, and biofeedback devices.

  Recruiting Hospices Civils de Lyon · Hyères · NCT06986421

• Early detection of type 1 diabetes using a finger‑prick blotting‑paper antibody test

  We will test whether a combined antibody test on finger‑prick blotting paper can reliably detect the three common type 1 diabetes autoantibodies in children newly diagnosed with type 1 diabetes.

  Recruiting Hospices Civils de Lyon · Bron, Rhône · NCT06984185

• Sleep and practice effects on memory in epilepsy

  This study will test whether a night of sleep or extra practice helps adults with epilepsy remember object‑place pairs better than staying awake.

  Recruiting Hospices Civils de Lyon · Bron · NCT06967935

• Attention capture by real-life episodic memories in healthy volunteers

  This study tests whether personal memories from real life can influence where people focus their attention and eye movements, using mobile technology and brain imaging in healthy adults.

  Recruiting Hospices Civils de Lyon · Bron, Rhone · NCT06934902

• Blood clearance of nucleosomes and CTCF after surgery for colorectal cancer with peritoneal spread

  This test will see if blood levels of nucleosomes and CTCF can indicate whether adults with colorectal cancer that has spread to the peritoneum have had all visible tumor removed by cytoreductive surgery.

  Recruiting Hospices Civils de Lyon · Pierre-Bénite · NCT06929013

• Phosphorus-31 Imaging to Explore Phosphate Diabetes in XLH

  This study tests phosphorus-31 spectroscopy to see if muscle and phosphate levels differ in people with phosphate diabetes (like XLH) compared with healthy peers.

  Recruiting Hospices Civils de Lyon · Bron and 1 other locations · NCT06921720

• Nutritional program to reduce frailty in people waiting for a liver transplant

  This trial will try a targeted nutritional management program to see if it reduces frailty in adults with cirrhosis who are on the liver transplant waiting list.

  Recruiting Hospices Civils de Lyon · Lyon · NCT06911619

• Enhanced Recovery After Surgery for Adolescent Idiopathic Scoliosis Surgery

  This study tests whether an enhanced recovery after surgery (ERAS) protocol helps teens recover after spinal fusion for idiopathic scoliosis.

  Recruiting at 11 sites Hospices Civils de Lyon · Amiens and 10 other locations · NCT06908213

• Monitoring brain function in neurocritical care patients

  This study looks at how brain function changes in patients with serious brain injuries during their first week in critical care to better understand their condition and improve treatment.

  Recruiting Hospices Civils de Lyon · France, Bron · NCT06900101

• Evaluating the effectiveness and safety of Dalbavancin for infection treatment

  This study is testing if Dalbavancin, a long-lasting antibiotic, is safe and effective for people who have been on other antibiotics for their infections.

  Recruiting Hospices Civils de Lyon · France, Lyon · NCT06899906

• Comparing two methods of monitoring heart function during liver transplantation

  This study is testing two different ways to monitor heart function during liver transplant surgery to see which method gives better information for doctors.

  Recruiting Hospices Civils de Lyon · France, Lyon · NCT06899867

• How people with Parkinson's disease perceive social cues

  This trial tries to see if dopaminergic medication changes brain activity during social perception tasks in people with Parkinson's disease using a behavioral point-light display task and 3T fMRI.

  Recruiting Hospices Civils de Lyon · Bron · NCT06884722

• Link between MASH and mitochondrial membrane changes in people having bariatric surgery.

  We will test whether changes in mitochondria-associated membranes (MAMs) in liver cells and blood immune cells are linked to MASH in adults undergoing bariatric surgery.

  Recruiting at 2 sites Hospices Civils de Lyon · Lyon, France and 1 other locations · NCT06868992

• Optical brain imaging for X-linked intellectual disabilities

  This project will try using noninvasive optical brain imaging (fNIRS) together with cognitive tests in males aged 5–35 who have Fragile X syndrome or creatine transporter deficiency to look for patterns of brain function.

  Recruiting Hospices Civils de Lyon · Bron · NCT06868979

• Re-treatment with a targeted radiotherapy for men with advanced prostate cancer

  This study is testing if giving a targeted radiotherapy again can help men with advanced prostate cancer who previously responded to the treatment feel better and live longer.

  Recruiting Phase 2 Hospices Civils de Lyon · Bordeaux and 15 other locations · NCT06866938

• Comparing robotic and laparoscopic approaches for bariatric surgery costs and outcomes

  This project will test whether robot-assisted bariatric surgery gives adults eligible for primary or revision bariatric procedures better quality-of-life outcomes that justify its higher cost.

  Recruiting at 17 sites Hospices Civils de Lyon · Bordeaux and 17 other locations · NCT06858761

• Nephroprotection for severe trauma patients with early urine signs of kidney stress

  This trial tests whether giving an early nephroprotection bundle to adults with severe trauma and a urine biomarker showing kidney stress can reduce acute kidney injury.

  Recruiting at 6 sites Hospices Civils de Lyon · Clermont-Ferrand and 5 other locations · NCT06834633

• TTV-guided long-term immunosuppression in kidney transplant recipients

  This trial tests whether checking Torque Teno Virus (TTV) levels every three months starting in the second year after transplant can help tailor immunosuppressive drugs for adult kidney transplant recipients to reduce infections, rejection, and cancer.

  Recruiting at 2 sites Hospices Civils de Lyon · Bordeaux (France) and 3 other locations · NCT06829719

• Evaluating information given to parents during prenatal consultations

  This study is trying to see if the information parents get during prenatal visits matches their experiences after their baby is born, especially regarding issues like congenital anomalies and prematurity.

  Recruiting Hospices Civils de Lyon · Bron · NCT06820892

• Children's quality of life before and after catheter ablation for arrhythmia

  This will see if catheter ablation improves quality of life in children aged 8–17 who need the procedure for arrhythmia.

  Recruiting at 4 sites Hospices Civils de Lyon · Bron and 6 other locations · NCT06808204

• Carotid Plaque Characterization with New Ultrasound Techniques

  This study tests ultrasound-based methods to characterize carotid plaques to better identify patients who may benefit from treatment.

  Recruiting Hospices Civils de Lyon · Lyon · NCT06804707

• Exploring gut microbes in adults with IBS and constipation who produce excess methane

  This study tests whether stool and blood samples show distinct gut microbes in adults with IBS and predominant constipation who have high methane on a breath test.

  Recruiting Hospices Civils de Lyon · Lyon · NCT06801184

• Thinking and mood changes from ALK/ROS1 targeted drugs in metastatic lung cancer and a patient-research care pathway

  This project will look at thinking, memory, and mood changes in adults in France taking ALK/ROS1-targeted drugs for metastatic lung cancer to see how these effects affect daily life and to build a patient-research care pathway.

  Recruiting at 2 sites Hospices Civils de Lyon · Bron and 1 other locations · NCT06781905

• Extracorporeal iron purification with MEX-CD1 for patients with MDS or myelofibrosis

  This study will try using an external blood-filter device (MEX-CD1) to remove excess iron in transfusion-dependent patients with myelodysplastic syndrome or myelofibrosis who cannot tolerate standard chelation.

  Recruiting at 2 sites Hospices Civils de Lyon · Oullins-Pierre-Bénite and 1 other locations · NCT06781099

• Impact of ultra-processed foods on rheumatic diseases

  This study looks at how eating ultra-processed foods might affect people with chronic rheumatic diseases like rheumatoid arthritis and osteoarthritis to see if it makes their symptoms worse.

  Recruiting Hospices Civils de Lyon · Lyon · NCT06776965

• Creating a quick quality-of-life questionnaire for people with short bowel syndrome

  This project will try a shorter, easier quality-of-life questionnaire for adults with short bowel syndrome and compare it with the existing SBS QoL tool.

  Recruiting Hospices Civils de Lyon · Pierre-Bénite · NCT06771505

• Non-invasive ventilation versus high-flow oxygen for recent chest trauma

  We will try a 10-minute session of non-invasive ventilation or high-flow oxygen and then do a CT scan to see how each affects the lungs of adults hospitalized with hypoxemic chest trauma.

  Recruiting Hospices Civils de Lyon · Lyon, Rhône · NCT06735872

• Identifying biomarkers for cardiovascular events in aortic stenosis patients

  This study is trying to find biological markers that can help identify aortic stenosis patients at risk for heart problems, especially those getting a new heart valve, so they can get treatment sooner.

  Recruiting at 2 sites Hospices Civils de Lyon · Lyon and 1 other locations · NCT06713889

• Understanding the immune response in COVID-19 patients

  This study is trying to see how the immune response works in people with different severities of COVID-19 and if certain genetic factors affect how well it fights the virus.

  Recruiting Hospices Civils de Lyon · Lyon · NCT06703034

• Diagnosing neurodevelopmental disorders in adults

  This study is looking to see how we can better identify neurodevelopmental disorders like ADHD and autism in adults who were diagnosed after 18, so they can get the support they need.

  Recruiting Hospices Civils de Lyon · Bron · NCT06691048

• Predicting tooth wear using advanced scanning techniques

  This study is testing a new scanning method to see if it can help predict tooth wear early on, so people can take better care of their teeth before serious damage happens.

  Recruiting at 5 sites Hospices Civils de Lyon · Indianapolis, Indiana and 4 other locations · NCT06681844

• Using AI to analyze heart changes in patients with high blood pressure

  This study is testing if artificial intelligence can help doctors understand heart changes in patients with high blood pressure by analyzing their heart scans and health information.

  Recruiting Hospices Civils de Lyon · Pierre-Bénite · NCT06680986

• Preparing patients for kidney transplantation with endovascular techniques

  This study is testing a new way to prepare the blood vessels of patients with kidney failure so they can safely receive a kidney transplant.

  Recruiting Hospices Civils de Lyon · Bron · NCT06677437

• Rehabilitation for patients with vestibular deficits using head impulse testing

  This study is testing a new rehabilitation method using head movement exercises to help people with balance issues from vestibular problems, like vestibular schwannoma, see if it improves their eye and balance function compared to a simple eye movement treatment.

  Recruiting Hospices Civils de Lyon · Bron · NCT06660082

• Assessing oral feeding skills in very premature infants

  This study looks at how very premature babies learn to feed by mouth and what challenges they face in making that transition from tube feeding.

  Recruiting Hospices Civils de Lyon · Lyon · NCT06657729

• Using a multi-infusion strategy to reduce infections in premature infants

  This study tests if using special devices to give multiple medications can help reduce infections in premature infants.

  Recruiting Hospices Civils de Lyon · Bron and 2 other locations · NCT06656104

• Using impedancemetry to monitor hydration and sodium levels in patients with subarachnoid hemorrhage

  This study is testing if a new method to check hydration and sodium levels can help improve recovery for adults who have had a serious type of stroke called subarachnoid hemorrhage.

  Recruiting Hospices Civils de Lyon · Lyon, France · NCT06646484

• Understanding hospital-acquired respiratory virus infections

  This study is trying to learn more about respiratory virus infections that people catch in hospitals and see how vaccines might help prevent them.

  Recruiting Hospices Civils de Lyon · Bordeaux and 5 other locations · NCT06643039

• Investigating the role of microbiota in small-intestine neuroendocrine tumors

  This study is trying to see how the bacteria in the gut might affect the growth of small-intestine neuroendocrine tumors in people.

  Recruiting Hospices Civils de Lyon · Lyon, France · NCT06624865

• Global reflexology for pain relief in children with sickle cell disease

  Try global reflexology to see if it reduces pain in children under 18 hospitalized for sickle cell vaso-occlusive crises.

  Recruiting Hospices Civils de Lyon · Bron · NCT06619197

• Investigating factors that influence polyp development in patients with Familial Adenomatous Polyposis

  This study looks at how gut bacteria and environmental factors might affect polyp growth in people with Familial Adenomatous Polyposis who have had preventive surgery and regular check-ups.

  Recruiting at 2 sites Hospices Civils de Lyon · Lyon, France and 1 other locations · NCT06614738

• Organizing care for cystic fibrosis patients using new treatments

  This study looks at how new cystic fibrosis treatments are changing the way care is organized and delivered to patients in France.

  Recruiting Hospices Civils de Lyon · Lyon · NCT06599892

• Relative dose intensity of PARP inhibitors in people over 70 with advanced ovarian cancer

  This project will see how often people age 70 and older with advanced ovarian cancer can stay on full PARP inhibitor doses and how blood-related side effects lead to dose changes in routine care.

  Recruiting at 16 sites Hospices Civils de Lyon · Amiens and 15 other locations · NCT06572735

• Type 2 diabetes with fatty liver: new markers to track disease progression and outcomes

  This project will test whether baseline non‑invasive blood and liver scan markers can tell which people with type 2 diabetes and fatty liver will have worsening liver disease or related complications.

  Recruiting at 4 sites Hospices Civils de Lyon · Dijon and 3 other locations · NCT06567990

• Understanding music perception in children with Rolandic epilepsy

  This study is trying to see how children with a specific type of epilepsy understand music and whether musical activities can help improve their thinking skills.

  Recruiting Hospices Civils de Lyon · Bron, Bron and 1 other locations · NCT06545708

• Understanding breathing and arousal changes in patients with drug-resistant epilepsy

  This study looks at how breathing problems and sleep changes affect adults with drug-resistant epilepsy to better understand their risk of sudden death related to seizures.

  Recruiting Hospices Civils de Lyon · Bron, Rhone · NCT06545214

• Circadian rhythm changes in people with CAPS

  This project will test whether people with CAPS have altered circadian rhythms by measuring sleep timing, saliva melatonin, and NLRP3 genetics and comparing them to healthy household members.

  Recruiting Hospices Civils de Lyon · Bron and 5 other locations · NCT06544018

• Examining physical activity and sedentary behavior in adults with cystic fibrosis

  This study looks at how active or inactive adults with cystic fibrosis are to see how it affects their health and quality of life.

  Recruiting Hospices Civils de Lyon · Pierre-Bénite · NCT06507956

• Instrumental respiratory physiotherapy for patients struggling to wean off ventilators

  This study tests if a new type of breathing therapy can help patients who have trouble getting off ventilators feel better and cough stronger than with regular therapy.

  Recruiting at 2 sites Hospices Civils de Lyon · Lyon, France and 2 other locations · NCT06499389

• Understanding how food intake affects sleep in narcolepsy and hypersomnia patients

  This study is testing how what people eat affects their sleep and daytime sleepiness in patients with narcolepsy and hypersomnia to find better ways to manage their health.

  Recruiting Hospices Civils de Lyon · Clermont-Ferrand and 1 other locations · NCT06484348

• Improving quality of life for patients with severe aortic stenosis

  This study looks at how severe aortic stenosis affects the daily lives of patients to see if a new heart valve procedure can help improve their quality of life.

  Recruiting Hospices Civils de Lyon · Clermont-Ferrand and 3 other locations · NCT06477042

• Tracking walking movements during labor with inertial sensors

  This study is testing how walking during the first stage of labor affects the experience and outcomes for women who are at least 38 weeks pregnant and using low-dose epidurals.

  Recruiting Hospices Civils de Lyon · Lyon · NCT06471790

• Examining the Aortic to Radial Pressure Gradient in Shock Conditions

  This study looks at how pressure differences between arteries in patients experiencing shock can help doctors better manage their treatment while they are on medication to support blood pressure.

  Recruiting at 9 sites Hospices Civils de Lyon · Bron and 8 other locations · NCT06460519

• Exploring mind-wandering and its effects in narcolepsy and hypersomnolence

  This study is testing how daydreaming affects thinking and creativity in people with narcolepsy and excessive sleepiness.

  Recruiting Hospices Civils de Lyon · Lyon · NCT06457945

• Assessing quality of life in children with posterior urethral valves

  This study looks at how being treated for posterior urethral valves affects the quality of life for boys aged 6 to 17, focusing on their kidney health and daily living.

  Recruiting Hospices Civils de Lyon · Bron, Bron · NCT06439862

• Collection of biological samples for rare pediatric autoimmune and autoinflammatory diseases

  This study is collecting blood and tissue samples from kids with rare autoimmune diseases to help researchers learn more about these conditions and improve diagnosis.

  Recruiting at 4 sites Hospices Civils de Lyon · Bron, Bron and 12 other locations · NCT06435468

• Daily pattern of urinary copper in people with Wilson disease

  This study will test whether urinary copper levels change during the day in people with Wilson disease and whether single spot urine samples can reflect 24-hour copper loss.

  Recruiting Hospices Civils de Lyon · Bron, Rhone · NCT06430359

• Blood viscosity and clotting risk in people with polycythemia

  This study will see if measuring blood thickness and clotting tests can help explain who is more likely to develop blood clots among adults with primary or secondary polycythemia.

  Recruiting Hospices Civils de Lyon · Pierre-Bénite, Lyon · NCT06421025

• Peer support for people with alcohol dependence

  This study tests whether peer support from someone with lived experience of addiction helps adults with alcohol use disorder stay in care and improve outcomes after detox.

  Recruiting Hospices Civils de Lyon · Bron and 4 other locations · NCT06381609

• Testing how well men can operate their penile implant pump

  This test will see if men with penile implants can operate the pump properly and whether that ability is linked to erection firmness and sexual satisfaction.

  Recruiting Hospices Civils de Lyon · Pierre-Bénite · NCT06376513

• Improving symptoms by removing the Essure contraceptive implant

  This study is testing if removing the Essure contraceptive implant can help women aged 35 to 75 who are having problems with the device feel better.

  Recruiting Hospices Civils de Lyon · Angers and 9 other locations · NCT06355713

• Creating a tissue model to enhance care for endometriosis

  This study is trying to create a new tissue model to help doctors better understand endometriosis and see how different hormonal treatments might work for patients.

  Recruiting at 2 sites Hospices Civils de Lyon · Bron and 1 other locations · NCT06331676

• Characterizing new patient types with spinal muscular atrophy treated with SMN therapies

  This study is trying to understand how different types of spinal muscular atrophy in children under 16 respond to new treatments that boost SMN protein levels, while also looking at their muscle strength, thinking skills, and heart health over two years.

  Recruiting Hospices Civils de Lyon · Bron, Rhone and 7 other locations · NCT06321965

• Oncoral multidisciplinary monitoring for adults taking oral anticancer medicines

  This project will test whether Oncoral's city–hospital monitoring and patient questionnaires help spot safety problems and improve care for adults taking oral anticancer drugs as outpatients.

  Recruiting Hospices Civils de Lyon · Pierre-Bénite · NCT06317389

• Exploring the role of gut bacteria in alcoholic hepatitis

  This study is trying to see how gut bacteria affect liver damage in people with severe alcoholic hepatitis to find new ways to help them feel better.

  Recruiting Hospices Civils de Lyon · Lyon · NCT06307964

• Remote conditioning for patients after out-of-hospital cardiac arrest

  This study tests if a new treatment called remote ischemic conditioning can help protect organs and improve survival for patients who have had a cardiac arrest outside of the hospital.

  Recruiting at 7 sites Hospices Civils de Lyon · Bron and 13 other locations · NCT06306625

• New treatment to prevent Clostridioides difficile infection recurrence in high-risk patients

  This study is testing a new treatment called EXL01 to see if it can help high-risk patients who keep getting Clostridioides difficile infections stay infection-free.

  Recruiting at 9 sites Phase 1/2 Hospices Civils de Lyon · Annecy and 9 other locations · NCT06306014

• Evaluating breast cancer response using advanced imaging techniques

  This study is testing if a new imaging technique called CESM can better show how well chemotherapy is working for patients with stage II and III HER2 positive or triple-negative breast cancer.

  Recruiting Hospices Civils de Lyon · Lyon · NCT06299202

• Analgesia Nociception Index monitoring of the autonomic nervous system during continuous renal replacement therapy

  We will try using the Analgesia Nociception Index to see if changes in autonomic signals match blood pressure and heart responses when fluid is removed during continuous renal replacement therapy in critically ill adults.

  Recruiting Hospices Civils de Lyon · Bron · NCT06285162

• Guided fluid removal using VeXUS score for patients with acute kidney injury after heart surgery

  This study is testing if using the VeXUS score to manage fluid levels can help patients with acute kidney injury after heart surgery recover better than standard care.

  Recruiting Hospices Civils de Lyon · Bron, Bron and 1 other locations · NCT06251713

• Understanding how circadian rhythms affect recovery from coma

  This study is trying to see how our body's natural clock affects the recovery of patients in a coma after a brain injury.

  Recruiting Hospices Civils de Lyon · Bron, Lyon · NCT06245434

• Whole-head helium-4 optically pumped magnetometer (OPM He4) brain scanner for faster brain recordings

  This project will test whether a new whole-head brain scanner using helium-4 sensors can pick up and map brain activity in healthy adults and athletes with mild concussion.

  Recruiting Hospices Civils de Lyon · Bron and 1 other locations · NCT06244472

• Assessing sexual health needs in patients with advanced cancer

  This study is trying to understand the sexual health needs of people with advanced cancer to see how it affects their quality of life and find ways to improve their care.

  Recruiting at 3 sites Hospices Civils de Lyon · Lyon and 2 other locations · NCT06229158

• Follow-up of patients with primary hyperoxaluria type 1 treated with Lumasiran in France

  This study is looking at how well Lumasiran works and how safe it is for people in France with primary hyperoxaluria type 1 over five years.

  Recruiting at 7 sites Hospices Civils de Lyon · Besançon and 6 other locations · NCT06225882

• Evaluating a new method for identifying pathogens and antibiotic resistance in sepsis patients

  This study is testing a new method to quickly identify germs and their resistance to antibiotics in sepsis patients to see if it can improve their treatment and outcomes.

  Recruiting at 16 sites Hospices Civils de Lyon · Bron and 22 other locations · NCT06219135

• Personalized non-invasive brain stimulation for drug-resistant neuropathic pain

  This tests personalized non-invasive brain stimulation (tDCS or tACS) to try to reduce chronic drug-resistant neuropathic pain in adults.

  Recruiting Hospices Civils de Lyon · Bron · NCT06209645

• Descriptive study of severe infections treated with phage therapy

  This study looks at how well phage therapy works for people with severe infections by gathering information from 250 patients treated at a hospital in Lyon.

  Recruiting Hospices Civils de Lyon · Lyon · NCT06185920

• Early intervention program for children with cerebral palsy

  This study is testing a new early intervention program for newborns at high risk of cerebral palsy to see if it can improve their movement, thinking, and communication skills with the help of their parents.

  Recruiting at 8 sites Hospices Civils de Lyon · Annecy and 7 other locations · NCT06180291

• Using chest bioreactance to improve fluid therapy in lung surgery

  This study tests if using a new chest monitoring device can help doctors give better fluid treatment to patients having lung surgery, compared to the usual care.

  Recruiting at 10 sites Hospices Civils de Lyon · Bron and 9 other locations · NCT06156943

• Examining liver inflammation in patients with non-alcoholic steatohepatitis

  This study is trying to see if examining liver inflammation in people with non-alcoholic steatohepatitis can help identify those at risk for serious liver problems.

  Recruiting Hospices Civils de Lyon · Lyon, Auvergne-Rhône-Alpes · NCT06152250

• Comparing two surgical techniques for ACL reconstruction

  This study is testing which of two surgical methods for ACL reconstruction works better for people with knee instability caused by additional ligament injuries.

  Recruiting Hospices Civils de Lyon · Lyon · NCT06147427

• Examining TLR4+ Blood Cells in Patients with Solid Cancer

  This study is testing how certain immune cells in the blood can be activated to improve immunotherapy for patients with solid cancers who are just starting treatment.

  Recruiting at 4 sites Hospices Civils de Lyon · Bron and 3 other locations · NCT06131775

• Understanding early symptoms of menstrual staphylococcal toxic shock

  This study is trying to find out the early warning signs of menstrual staphylococcal toxic shock syndrome in young women aged 13 to 30 to help with quicker diagnosis and understanding of this serious condition.

  Recruiting Hospices Civils de Lyon · Lyon · NCT06124599

• Understanding genetic syndromes linked to RNU4ATAC mutations

  This study is trying to understand how changes in the RNU4ATAC gene affect rare genetic syndromes like Taybi Linder Syndrome and Roifman Syndrome, which can cause growth and developmental problems.

  Recruiting Hospices Civils de Lyon · Bordeaux and 5 other locations · NCT06111950

• Using a structured DISCUSS protocol to announce withholding or stopping life support to relatives in emergency departments

  This project will test whether training emergency staff to use the DISCUSS announcement protocol reduces stress and later PTSD‑related symptoms in relatives told that life‑support will be limited or stopped.

  Recruiting at 9 sites Hospices Civils de Lyon · Angers and 8 other locations · NCT06071078

• Validation of biomarkers to reduce antibiotic use in newborns with suspected infections

  This study is testing if certain biomarkers can help doctors better diagnose infections in newborns so they can use fewer antibiotics in the NICU.

  Recruiting at 3 sites Hospices Civils de Lyon · Bron and 2 other locations · NCT06058819

• Evaluating kidney function after living donor transplants using MRI.

  This study is testing if MRI scans can help doctors better understand how well kidneys from living donors work after being transplanted, especially for patients waiting for a kidney transplant.

  Recruiting Hospices Civils de Lyon · Lyon · NCT06047106

• Evaluating the HBV Reservoir and Immunological Characteristics in Chronic Hepatitis B Patients

  This study is trying to understand how the hepatitis B virus hides in the liver and affects the immune system in people with chronic hepatitis B to help find better treatments.

  Recruiting Hospices Civils de Lyon · Lyon · NCT06047093

• Evaluating quality of life for patients treated with vectorized internal radiotherapy for neuroendocrine tumors.

  This study is trying to see how vectorized internal radiotherapy affects the quality of life for patients with metastatic neuroendocrine tumors.

  Recruiting at 4 sites Hospices Civils de Lyon · Saint-Priest-en-Jarez, Saint-Etienne and 3 other locations · NCT06043193

• MRI-guided radiotherapy for cancer treatment

  This study is testing a new way of giving radiation therapy for cancer that uses MRI technology to better target tumors and improve treatment for patients with different types of cancer.

  Recruiting Hospices Civils de Lyon · Lyon · NCT06041555

• Rehabilitation for spatial hearing in children with cochlear implants

  This study tests a virtual reality program to help children with cochlear implants improve their ability to hear and understand sounds in noisy places.

  Recruiting Hospices Civils de Lyon · Lyon · NCT06040892

• Comparing two methods of renal replacement therapy for patients on ECMO

  This study is testing two different ways to provide kidney treatment for patients on ECMO to see which method causes fewer complications like infections and bleeding.

  Recruiting at 9 sites Hospices Civils de Lyon · Bordeaux and 11 other locations · NCT06038162

• Evaluating outcome measures for creatine transporter deficiency

  This study is trying to see how creatine transporter deficiency affects patients' lives and development by looking at their health and quality of life compared to others without the condition.

  Recruiting Hospices Civils de Lyon · Bron · NCT06018519

• Comparing thigh ultrasound muscle size with whole-body muscle measurements after cancer

  This study tests whether a quick ultrasound of the thigh can estimate whole-body muscle mass in adults who have completed cancer treatment.

  Recruiting Hospices Civils de Lyon · Pierre-Bénite · NCT06007794

• Registry for aggressive pituitary tumors

  This study is collecting information on aggressive pituitary tumors to help doctors better understand and manage these cases for patients.

  Recruiting Hospices Civils de Lyon · Lyon · NCT05974696

• Using hypnosis to help manage anxiety in hematologic cancer patients

  This study tests whether hypnosis can help adults with certain blood cancers feel less anxious about their diagnosis and treatment.

  Recruiting Hospices Civils de Lyon · Lyon, Pierre-Bénite · NCT05942885

Showing recruiting studies first, then the newest. Describe your situation to find the ones that fit you.

Quick answers

How many clinical trials run by Hospices Civils de Lyon are recruiting right now?

264, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in France (264 trials), United States (2 trials), Italy (1 trial), Guadeloupe (1 trial), Martinique (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 3: 4, Phase 1/2: 3, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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