Using [18F]FET PET to find ACTH-secreting pituitary microadenomas

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational cohort combines retrospective and prospective data to compare [18F]FET PET imaging with standard pituitary MRI for localizing corticotroph microadenomas. Localization on PET will be compared with postoperative histopathology as the reference standard. Secondary goals include measuring how often PET changes the presumed tumor location relative to MRI and whether two readers agree on PET findings. The study aims to determine if PET can inform surgical planning and potentially reduce the need for invasive inferior petrosal sinus sampling.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults (≥18 years).
* Biochemical diagnosis of Cushing's disease as part of initial management.
* Pituitary MRI performed; if visible, microadenoma \<10 mm in diameter.
* Indication for discussion in multidisciplinary tumor board for surgical management.

Exclusion Criteria:

* Minor (age \<18 years).
* Macroadenoma of the pituitary.
* ACTH-dependent hypercortisolism secondary to ectopic secretion.

Where it's running

• Hôpital Louis Pradel - Service de Médecine Nucléaire
  Bron, France Recruiting

Study contacts

• Study coordinator: Anthime FLAUS, MD
• Email: anthime.flaus@chu-lyon.fr
• Phone: +33 4 72 35 69 99

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.