Investigating factors that influence polyp development in patients with Familial Adenomatous Polyposis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the microbial and environmental factors that contribute to the development of polyps in individuals with Familial Adenomatous Polyposis (FAP). Participants will provide fecal and duodenal fluid samples to analyze the gut microbiota and its potential role in adenoma formation. The study will focus on patients who have undergone prophylactic colectomy and are under regular endoscopic surveillance. By understanding these factors, the research seeks to identify variations in polyp development among patients with the same genetic mutation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ≥18 years
* Non-opposition obtained
* Prophylactic colectomy for at least 2 years in the context of APC-related familial adenomatous polyposis with ileorectal or ileoanal anastomosis
* Included in the national POLYPOSE database
* Regular endoscopic follow-up with upper and lower GI endoscopy at Hôpital Edouard Herriot or Hôpital de la Croix-Rousse
* Having performed at least 2 endoscopies as part of follow-up

Exclusion Criteria:

* Antibiotic therapy within 2 months prior to stool sampling
* Taking probiotics for less than 1 month
* Person deprived of liberty by judicial or administrative decision

Where it's running

• Hôpital Edouard Herriot
  Lyon, France, France Recruiting
• Hôpital de la Croix Rousse
  Lyon, France, France Recruiting

Study contacts

• Study coordinator: Nicolas BENECH, MD PhD
• Email: nicolas.benech@chu-lyon.fr
• Phone: +33426109435

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• ONC201 (dordaviprone) for safety and prevention of colorectal polyps in high-risk adults.

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• Evaluating REC-4881 for treating Familial Adenomatous Polyposis

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.