Intracranial Mapping of Cortical Control of Breathing in Epilepsy
Official title: Intracranial CArtography of Cortical Contribution to Respiratory Load Compensation in Epilepsy
Run by Hospices Civils de Lyon · NCT07599150 · Data updated 2026-11-12
This study tests whether targeted brain area activity during SEEG can reveal how the cortex helps regulate breathing in people with drug-resistant epilepsy.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 55 Years |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | Hospices Civils de Lyon Academic / other |
| Locations | 1 site (Bron, Rhone) |
| Status | Recruiting |
| Started | September 17, 2026 |
| Main results expected | September 17, 2028 |
| Study ends | September 17, 2028 |
| Registry record updated | September 23, 2026 |
| Trial ID | NCT07599150 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–55 with drug-resistant focal epilepsy undergoing SEEG with electrodes in perisylian and premotor cortex.
✕Probably not a fit
Patients without the specified SEEG electrode localization or those not undergoing presurgical evaluation may not benefit from this research.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study uses SEEG monitoring along with comprehensive respiratory and cardio-respiratory monitoring to examine how cortical regions contribute to breathing control during epileptic activity. Participants are adults with drug-resistant focal epilepsy undergoing presurgical evaluation, with SEEG electrodes in perisylvian and premotor areas. The protocol includes expiratory load challenges and hypercapnic tests to assess respiratory responses. Results could improve understanding of SUDEP risk and inform preventive strategies during the post-ictal period.
Why it matters
Potential benefit: If successful, the findings could guide better monitoring and interventions to prevent post-ictal breathing impairment in epilepsy.
How similar studies have gone: Previous studies suggest cortical involvement in breathing control, but this specific intracranial mapping approach is novel in epilepsy-related respiratory research.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Written informed consent obtained from study subject and ability for study subject to comply with the requirements of the study 2. Aged 18 to 55 years old 3. Diagnosis of drug-resistant focal epilepsy, as defined by the International League Against Epilepsy 20 4. Patients undergoing SEEG as part of presurgical evaluation 5. At least one SEEG electrode localized in the perisylvian cortex 6. At least one SEEG electrode localized in the premotor cortex Exclusion Criteria: 1\. Ongoing or chronic respiratory and/or cardiac insufficiency and/or ischemic cardiac disease 2. History of stroke in the last 5 years 3. Intracranial hypertension related to space-occupying lesion in the brain 4. Pregnant, parturient, or breastfeeding women 5. Individuals receiving psychiatric care 6. Individuals deprived of their liberty by judicial or administrative decision 7. Adults subject to legal protection measures (guardianship, curatorship) 8. Individuals not affiliated with a social security scheme or beneficiaries of a similar scheme \-
Where it's running
-
Service de Neurologie Fonctionne et d'Epileptologie Hôpital Neurologique Pierre WERTHEIMER
Bron, Rhone, France Recruiting
Study contacts
- Study coordinator: Sylvain RHEIMS, Pr
- Email: sylvain.rheims@chu-lyon.fr
- Phone: 04 72 35 70 44
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.