Exploring mind-wandering and its effects in narcolepsy and hypersomnolence

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the phenomenon of mind-wandering in patients with narcolepsy type 1 and idiopathic hypersomnia. It aims to understand how task-unrelated thoughts impact cognitive performance and whether they can have beneficial effects, such as enhancing creativity and memory. Participants will undergo various cognitive tasks while their mental content is assessed through questionnaires and electrophysiological recordings. The study seeks to clarify the relationship between mind-wandering and cognitive processes in individuals with hypersomnolence disorders.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with NT1 or IH diagnosis according to ICSD3-TR criteria (American Academy of Sleep, 2023)
* For patient with IH: with abnormal Mean Sleep Latency Test (MSLT) (mean latency ≤ 8 min, ≤ 1 SOREMp)
* Patients with subjective hypersomnolence without underlying cause (negative extensive work-up including actigraphy, PSG, MSLT, 24h bedrest, biological tests, MRI, psychiatric consultation; this allows to rule out sleep deprivation, irregular sleep/wake schedule, sleep apnea or other sleep disorders associated with sleep fragmentation, somatic/psychiatric causes of hypersomnolence, sedative substance intake). This type of "controls" have already been used in studies on hypersomnolence disorders.

Exclusion Criteria:

* Cognitive impairment not compatible with the task
* Treatment with antidepressant
* Other cause of hypersomnolence: untreated severe obstructive sleep apnea, sleep-wake circadian rhythm disorders, sleep deprivation, somatic/psychiatric causes of hypersomnolence, sedative substance intake
* Unstable medical or psychiatric condition
* Refusal to participate

Where it's running

• Hôpital de la Croix-Rousse
  Lyon, France Recruiting

Study contacts

• Principal investigator: Laure PETER-DEREX, Professor — Hospices Civils de Lyon
• Study coordinator: Laure PETER-DEREX, Professor
• Email: laure.peter-derex@chu-lyon.fr
• Phone: +33 04 72 07 19 29

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.