Carotid Plaque Characterization with New Ultrasound Techniques
Official title: Tissue and Vascular Microstructure Evaluation for Carotid Plaque Characterization Using Innovative Ultrasound Techniques
Run by Hospices Civils de Lyon · NCT06804707 · Data updated 2026-11-12
This study tests ultrasound-based methods to characterize carotid plaques to better identify patients who may benefit from treatment.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 17 (estimated) |
| Sponsor | Hospices Civils de Lyon Academic / other |
| Locations | 1 site (Lyon) |
| Status | Recruiting |
| Started | May 13, 2025 |
| Main results expected | February 13, 2027 |
| Study ends | February 13, 2027 |
| Registry record updated | October 22, 2026 |
| Trial ID | NCT06804707 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with asymptomatic or symptomatic carotid plaque with greater than 50% stenosis (NASCET) referred for possible surgery and able to provide informed consent.
✕Probably not a fit
Patients with non-eligible plaque characteristics or those not undergoing surgical planning may not experience direct benefits from the study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study uses advanced ultrasound imaging, ultrasound localization microscopy, and backscatter measurements alongside high-resolution MRI plaque imaging to analyze carotid plaques. It aims to identify plaque composition and instability markers that go beyond stenosis degree alone. Participants include adults with carotid plaques undergoing surgical evaluation, who are consented and meet safety criteria. The study is conducted at a single center in Lyon, France, led by Hospices Civils de Lyon and focusing on patients referred for potential surgical intervention. Blood sampling is included as part of the protocol, and standard imaging modalities are used to correlate plaque features with surgical decisions.
Why it matters
Potential benefit: If successful, the approach could improve risk stratification and help tailor treatment decisions for patients with carotid plaque.
How similar studies have gone: Prior research supports using imaging to characterize plaque features, though this specific ultrasound-based characterization approach is innovative and not yet proven in this exact setting.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Female or male over 18 years of age * Patients with asymptomatic or symptomatic carotid plaque (stenosis\> 50% NASCET), referred by the Hospices Civils de Lyon (HCL) vascular surgery consultation and for whom a surgical indication has been retained. * Patient having agreed to participate in the study and signed a written informed consent form * Patient affiliated to a social security scheme or equivalent. Exclusion Criteria: * Patients with contraindications to Sonovue (right-to-left shunt, severe pulmonary hypertension, allergy to the molecule) * Patients with unstable cardiovascular pathology (coronary artery disease, stroke / transient ischemic attack, cardiac rhythm disorders) * Uncontrolled hypertension * Respiratory distress syndrome * Patients with contraindications to MRI (claustrophobia, presence of metallic elements, etc.). * Gadolinium-related contraindications and precautions for use * Contraindication to dobutamine * Hypersensitivity to the active substance or to one of the constituents of Gadolinium, * Renal insufficiency with clearance \<30 ml/min/1.73 m², * Pregnant or breast-feeding patients * Patients under guardianship or trusteeship
Where it's running
-
Hôpital de la Croix Rousse
Lyon, France Recruiting
Study contacts
- Principal investigator: Dr Ariane BLEROT, MD, PhD — Hospices Civils de Lyon
- Study coordinator: Dr. Ariane BLEROT, MD, PhD
- Email: ariane.blerot@chu-lyon.fr
- Phone: +33 4.72.07.16.78
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.