Sleep and practice effects on memory in epilepsy
Rehearsal-Induced Memory Consolidation and Its Modulation by Sleep in People With Epilepsy
This study will test whether a night of sleep or extra practice helps adults with epilepsy remember object‑place pairs better than staying awake.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 20 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Hospices Civils de Lyon Academic / other |
| Locations | 1 site (Bron) |
| Trial ID | NCT06967935 on ClinicalTrials.gov |
What this trial studies
Adults with epilepsy admitted for multi‑day video‑EEG monitoring learn object‑place associations under two conditions (single versus repeated encoding) and are tested immediately and after a 12‑hour delay that either includes a day awake or a night of sleep. During the tasks researchers record EEG, use eye tracking, and collect brief questionnaires on fatigue and task difficulty including the Karolinska scale. The design links behavioral memory performance to sleep and epilepsy-related brain activity to compare rehearsal‑ and sleep‑driven consolidation and any interaction between them. This is an observational bedside protocol conducted during standard clinical monitoring.
Who should consider this trial
Good fit: Adults 18–65 with epilepsy who are hospitalized for at least four days of video‑EEG monitoring, able to consent, and without major non‑memory cognitive impairment are ideal candidates.
Not a fit: People with major non‑memory cognitive impairment, those not undergoing inpatient video‑EEG monitoring, pregnant or nursing women, people under psychiatric care, or individuals under legal protection are unlikely to receive benefit from participation.
Why it matters
Potential benefit: If successful, the findings could point to simple strategies such as timing learning around sleep or adding rehearsal to help people with temporal lobe epilepsy improve memory.
How similar studies have performed: Sleep and rehearsal have been shown to boost memory in healthy volunteers, but their combined effects and impact in temporal lobe epilepsy remain poorly established.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient with epilepsy (any type of epilepsy) * Hospitalized for video-EEG recording lasting at least 4 days * Aged 18-65 years Exclusion Criteria: * Major cognitive impairment other than memory deficit * Refusal to participate * Pregnant women, women in labor or nursing mothers * Persons deprived of their liberty by judicial or administrative decision * Persons under psychiatric care * Persons admitted to a health or social institution for purposes other than research * Adults under legal protection (guardianship, curatorship)
Where this trial is running
Bron
- Service de neurologie fonctionnelle et d'épileptologie, Hôpital neurologique Pierre Wertheimer — Bron, France (Recruiting)
Study contacts
- Study coordinator: Laure PETER-DEREX, Professor
- Email: laure.peter-derex@chu-lyon.fr
- Phone: +334 72 07 17 69
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.