Evaluating kidney function after living donor transplants using MRI.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the performance of kidney grafts from living donors using multiparametric MRI to assess renal function. It focuses on patients with end-stage chronic kidney disease who are awaiting transplants and living donors with adequate glomerular filtration rates. The study aims to improve the selection process for kidney donations, especially from older donors, by utilizing advanced imaging techniques to better understand kidney function post-transplant. Interventions include MRI scans, kidney graft biopsies, and collection of blood and urine samples.

Why it matters

Who can join: the full rules

Inclusion Criteria:

For recipients:

* Patients with end-stage chronic kidney disease awaiting kidney transplant from a living donor.
* Adult patient
* Consent signed
* effective contraceptive method for women
* Patient affiliated to a social security or beneficiaries of a similar scheme

For donors:

* Individuals eligible for living kidney donation with GFR \> 60 mL/min/1.73 m².
* Adult patient
* Consent signed
* effective contraceptive method for women
* Patient affiliated to a social security or beneficiaries of a similar scheme

Exclusion Criteria:

For the two groups :

* MRI contraindications (claustrophobia, pacemaker, cardioverter defibrillators implantable, mechanical heart valve non MRI-compatible)
* Weight\> 130 kg
* Pregnant, parturient or breastfeeding
* Persons deprived of their liberty by a judicial or administrative decision,
* Adults subject to a legal protection measure (safeguard measure, guardianship, curators)
* subject participating in another research including an exclusion period still in progress at inclusion

For recipients :

\- Contraindication to renal graft biopsy (ongoing or uninterrupted anticoagulant or antiplatelet treatment, thrombocytopenia \<100 x 10\^9/L, anemia \<7 g/dL).

Where it's running

• Hôpital Edouard Herriot, Hospices Civils de Lyon
  Lyon, France Recruiting

Study contacts

• Principal investigator: Sandrine LEMOINE, PU-PH — Service de néphrologie à l'Hôpital Edouard Herriot
• Study coordinator: Sandrine LEMOINE, PU-PH
• Email: sandrine.lemoine01@chu-lyon.fr
• Phone: 04 72 11 02 44

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.