Evaluating kidney function after living donor transplants using MRI.
DOVIMIR : Multi-parametric MRI Evaluation of Renal Graft Performance After Living Donor Donation
This study is testing if MRI scans can help doctors better understand how well kidneys from living donors work after being transplanted, especially for patients waiting for a kidney transplant.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Hospices Civils de Lyon Academic / other |
| Locations | 1 site (Lyon, LYON) |
| Trial ID | NCT06047106 on ClinicalTrials.gov |
What this trial studies
This study evaluates the performance of kidney grafts from living donors using multiparametric MRI to assess renal function. It focuses on patients with end-stage chronic kidney disease who are awaiting transplants and living donors with adequate glomerular filtration rates. The study aims to improve the selection process for kidney donations, especially from older donors, by utilizing advanced imaging techniques to better understand kidney function post-transplant. Interventions include MRI scans, kidney graft biopsies, and collection of blood and urine samples.
Who should consider this trial
Good fit: Ideal candidates include adults with end-stage chronic kidney disease awaiting a kidney transplant from a living donor.
Not a fit: Patients with contraindications for MRI or those who are pregnant or breastfeeding may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the selection criteria for kidney donors, potentially improving transplant outcomes for patients with chronic kidney disease.
How similar studies have performed: While the use of multiparametric MRI in kidney evaluation is emerging, this specific approach to assess living donor kidney grafts is relatively novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: For recipients: * Patients with end-stage chronic kidney disease awaiting kidney transplant from a living donor. * Adult patient * Consent signed * effective contraceptive method for women * Patient affiliated to a social security or beneficiaries of a similar scheme For donors: * Individuals eligible for living kidney donation with GFR \> 60 mL/min/1.73 m². * Adult patient * Consent signed * effective contraceptive method for women * Patient affiliated to a social security or beneficiaries of a similar scheme Exclusion Criteria: For the two groups : * MRI contraindications (claustrophobia, pacemaker, cardioverter defibrillators implantable, mechanical heart valve non MRI-compatible) * Weight\> 130 kg * Pregnant, parturient or breastfeeding * Persons deprived of their liberty by a judicial or administrative decision, * Adults subject to a legal protection measure (safeguard measure, guardianship, curators) * subject participating in another research including an exclusion period still in progress at inclusion For recipients : \- Contraindication to renal graft biopsy (ongoing or uninterrupted anticoagulant or antiplatelet treatment, thrombocytopenia \<100 x 10\^9/L, anemia \<7 g/dL).
Where this trial is running
Lyon, LYON
- Hôpital Edouard Herriot, Hospices Civils de Lyon — Lyon, Lyon, France (Recruiting)
Study contacts
- Principal investigator: Sandrine LEMOINE, PU-PH — Service de néphrologie à l'Hôpital Edouard Herriot
- Study coordinator: Sandrine LEMOINE, PU-PH
- Email: sandrine.lemoine01@chu-lyon.fr
- Phone: 04 72 11 02 44
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.