Mobile low-dose CT lung cancer screening program
Lyon Initiative for the Mobile Demedicalized Initiation of Lung Cancer Screening
This project will try using a CT-equipped mobile unit versus a hospital screening unit to screen people aged 50–74 with a heavy smoking history.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 4312 (estimated) |
| Ages | 50 Years to 75 Years |
| Sex | All |
| Sponsor | Hospices Civils de Lyon Academic / other |
| Locations | 2 sites (Pierre-Bénite and 1 other locations) |
| Trial ID | NCT07015151 on ClinicalTrials.gov |
What this trial studies
MobILYAD compares a demedicalized CT-equipped mobile van staffed by trained nurses with a conventional hospital-based screening pathway at Hôpital Lyon Sud to determine which better reaches socially disadvantaged populations. Eligible participants receive low-dose chest CT, spirometry, a cardiovascular risk check, smoking cessation support, and optional biospecimen collection. The project uses a proactive 'reach-out' strategy informed by mobile screening models from other countries and by mobile mammography experience in France. Results will inform the national pilot program (IMPULSION) planned for 2025 by measuring participation, detection rates, and operational feasibility.
Who should consider this trial
Good fit: People aged 50–74 who are current smokers or who quit within the past 15 years with a substantial smoking history (roughly ≥20 pack-years or equivalent by specified conversion), covered by French social security, and able to provide informed consent.
Not a fit: People outside the age or smoking-history eligibility criteria or those with severe comorbidities that preclude LDCT or follow-up care are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, the mobile approach could increase screening uptake among underserved populations and help detect lung cancers earlier in high-risk smokers.
How similar studies have performed: Mobile outreach screening approaches have shown effectiveness in the UK, Brazil, and the USA and mobile mammography has been used in France, supporting the rationale though mobile LDCT in France is being newly tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria \* : * Persons aged over 50 and under 75 (74 years of age or older). * Active smokers or former smokers who quit less than 15 years ago. * Persons whose consumption is estimated at 20 packs/year or more, down to ≥15 cigarettes/day for a duration of consumption of ≥25 years and up to ≥10 cigarettes/day for ≥30 years, which takes into account the predominance of duration of consumption over quantity consumed in the risk of lung cancer. A pack-year corresponds to the consumption of one pack of 20 manufactured cigarettes per day for one year. A multiplier coefficient will be taken into account depending on the mode of consumption: Rolled cigarettes: 2; Cigarillos: 3; Cigars: 4; Pipes: 2.5; Hookahs: 25. * Persons affiliated with social security. - Person having signed their consent to participate in the study after having received full information about it, including the risks associated with participation. * Exclusion Criteria \* : * Individuals with severe comorbidities contraindicating lung cancer investigations and/or treatment (including surgery or stereotactic radiotherapy); * Individuals with impaired general condition (PS 2 and above); * Individuals with dyspnea at rest (mMRC4); * Individuals with a history of cancer undergoing active surveillance by chest computed tomography (CT or PET scan); personal history of lung cancer (lifetime); * Individuals with symptoms suggestive of lung cancer (hemoptysis, unexplained weight loss, recent onset or change in respiratory symptoms, etc.); * Individuals refusing to participate in the study * Individuals withdrawing their consent.
Where this trial is running
Pierre-Bénite and 1 other locations
- " Centre de dépistage mobile " - Hôpital Lyon Sud — Pierre-Bénite, France (Recruiting)
- Service de Pneumologie " Centre de dépistage non mobile " - Hôpital Lyon Sud — Pierre-Bénite, France (Recruiting)
Study contacts
- Study coordinator: Sébastien COURAUD, Pr
- Email: sebastien.couraud@chu-lyon.fr
- Phone: 04 78 86 44 01
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.