Identifying biomarkers for cardiovascular events in aortic stenosis patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify biological markers associated with cardiovascular events in patients suffering from aortic stenosis, particularly those undergoing Transcatheter Aortic Valve Implantation (TAVI). By assessing inflammatory and fibrosis factors through biomarkers, the study seeks to pinpoint asymptomatic patients at higher risk for earlier intervention. Patients will be recruited during their TAVI assessment consultations, and data will be collected from routine care procedures along with a biocollection of serum and plasma samples. Quality of life questionnaires will also be administered to gather comprehensive patient information.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients \>=18 years of age
* Patient with symptomatic or asymptomatic severe or moderately severe aortic stenosis (according to the recommendations of the European Society of Cardiology - ESC).
* No opposition.

Exclusion Criteria:

* Conjunctive heart disease (e.g. amyloidosis).
* Presence of a contraindication to TAVI.
* Impossibility of giving the subject informed information.
* Privation of civil rights (curatorship, tutorship, protection of justice).

Where it's running

• Hospices Civils de Lyon - Hôpital Croix Rousse
  Lyon, France Recruiting
• Hospices Civils de Lyon - Hôpital Louis Pradel
  Lyon, France Recruiting

Study contacts

• Principal investigator: Ahmad HAYEK, MD — Plateau technique interventionnel - Hôpital Louis Pradel, GHE
• Study coordinator: Ahmad HAYEK, MD
• Email: ahmad.hayek@chu-lyon.fr
• Phone: 4 72 35 72 80

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Exercise and nutrition support before and after TAVI for older adults with aortic stenosis

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• Echo-AVCS: Drawing AI-powered clues from heart scans to confirm severe aortic stenosis

  This study tests an AI-based echocardiography score to help confirm severe aortic stenosis in adults who are also getting CT calcium scoring.

  Recruiting at 4 sites Azienda Ospedaliera "Sant'Andrea" · Bologna and 4 other locations · NCT07620925

• TAVI without on-site heart surgery: can selected centers do it safely?

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• Willem AI for early detection of aortic stenosis from a 12‑lead ECG

  This project will test whether the Willem AI can detect aortic stenosis from routine 12‑lead ECGs in adults.

  Recruiting at 2 sites Idoven 1903 S.L. · Bonn and 1 other locations · NCT07479992

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.