MRI-guided radiotherapy for cancer treatment
Official title: MRI Guided Radiotherapy and Radiobiological Data: the ISRAR Database (Irm Sequences for Radiobiological Adaptative Radiotherapy)
Run by Hospices Civils de Lyon · NCT06041555 · Data updated 2026-11-12
This study is testing a new way of giving radiation therapy for cancer that uses MRI technology to better target tumors and improve treatment for patients with different types of cancer.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 600 (estimated) |
| Sponsor | Hospices Civils de Lyon Academic / other |
| Locations | 1 site (Lyon) |
| Status | Recruiting |
| Started | January 8, 2024 |
| Main results expected | January 8, 2029 |
| Study ends | January 8, 2029 |
| Registry record updated | February 20, 2024 |
| Trial ID | NCT06041555 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 and older diagnosed with prostate, kidney, cervix, head and neck cancer, or glioblastoma who are indicated for external radiotherapy.
✕Probably not a fit
Patients who are unable to maintain a lying position during the procedure or those who are pregnant or breastfeeding may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study utilizes the MRI linac Unity, a cutting-edge technology that combines a linear accelerator with a 1.5T MRI to enhance the precision of radiotherapy. It aims to adapt daily radiation doses based on the tumor's position, volume, and response, while also characterizing the radiosensitivity of both healthy and tumor tissues through specific MRI sequences. By generating 3D maps of intra-tumor radiosensitivity, the study seeks to optimize treatment plans and improve patient outcomes. The research is observational and focuses on patients diagnosed with various types of cancer who are receiving external radiotherapy.
Why it matters
Potential benefit: If successful, this approach could lead to more personalized and effective radiotherapy treatments for cancer patients.
How similar studies have gone: While the use of MRI in radiotherapy is gaining traction, this specific approach combining AI and detailed radiosensitivity mapping is relatively novel and has not been extensively tested in prior studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18years old or older * diagnosed with prostate, kidney, cervix, head and neck cancer or glioblastoma * indication of external radiotherapy * treated with the Linac UNITY MRI guided radiotherapy at the centre hospitalier Lyon Sud des Hospices Civils de Lyon * agreement of the patient to participate * affiliated to a social security system Exclusion Criteria: patient unable to keep a lying position during all the procedure * patient under law restriction * pregnant women or breastfeeding
Where it's running
-
Hôpital Lyon Sud/ service de Radiothérapie Oncologie
Lyon, France Recruiting
Study contacts
- Study coordinator: Olivier CHAPET, MD
- Email: Olivier.chapet@chu-lyon.fr
- Phone: 4 78 86 42 51
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.