Clinical trial Recruiting at 1 site Observational Ages 18 and up

MRI-guided radiotherapy for cancer treatment

Official title: MRI Guided Radiotherapy and Radiobiological Data: the ISRAR Database (Irm Sequences for Radiobiological Adaptative Radiotherapy)

Run by Hospices Civils de Lyon · NCT06041555 · Data updated 2026-11-12

This study is testing a new way of giving radiation therapy for cancer that uses MRI technology to better target tumors and improve treatment for patients with different types of cancer.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment600 (estimated)
SponsorHospices Civils de Lyon
Academic / other
Locations1 site (Lyon)
StatusRecruiting
StartedJanuary 8, 2024
Main results expectedJanuary 8, 2029
Study endsJanuary 8, 2029
Registry record updatedFebruary 20, 2024
Trial IDNCT06041555 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include adults aged 18 and older diagnosed with prostate, kidney, cervix, head and neck cancer, or glioblastoma who are indicated for external radiotherapy.

Probably not a fit

Patients who are unable to maintain a lying position during the procedure or those who are pregnant or breastfeeding may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study utilizes the MRI linac Unity, a cutting-edge technology that combines a linear accelerator with a 1.5T MRI to enhance the precision of radiotherapy. It aims to adapt daily radiation doses based on the tumor's position, volume, and response, while also characterizing the radiosensitivity of both healthy and tumor tissues through specific MRI sequences. By generating 3D maps of intra-tumor radiosensitivity, the study seeks to optimize treatment plans and improve patient outcomes. The research is observational and focuses on patients diagnosed with various types of cancer who are receiving external radiotherapy.

Why it matters

Potential benefit: If successful, this approach could lead to more personalized and effective radiotherapy treatments for cancer patients.

How similar studies have gone: While the use of MRI in radiotherapy is gaining traction, this specific approach combining AI and detailed radiosensitivity mapping is relatively novel and has not been extensively tested in prior studies.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* 18years old or older
* diagnosed with prostate, kidney, cervix, head and neck cancer or glioblastoma
* indication of external radiotherapy
* treated with the Linac UNITY MRI guided radiotherapy at the centre hospitalier Lyon Sud des Hospices Civils de Lyon
* agreement of the patient to participate
* affiliated to a social security system

Exclusion Criteria:

patient unable to keep a lying position during all the procedure

* patient under law restriction
* pregnant women or breastfeeding

Where it's running

  • Hôpital Lyon Sud/ service de Radiothérapie Oncologie
    Lyon, France
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.