MRI-guided radiotherapy for cancer treatment
MRI Guided Radiotherapy and Radiobiological Data: the ISRAR Database (Irm Sequences for Radiobiological Adaptative Radiotherapy)
This study is testing a new way of giving radiation therapy for cancer that uses MRI technology to better target tumors and improve treatment for patients with different types of cancer.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 600 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Hospices Civils de Lyon Academic / other |
| Locations | 1 site (Lyon) |
| Trial ID | NCT06041555 on ClinicalTrials.gov |
What this trial studies
This study utilizes the MRI linac Unity, a cutting-edge technology that combines a linear accelerator with a 1.5T MRI to enhance the precision of radiotherapy. It aims to adapt daily radiation doses based on the tumor's position, volume, and response, while also characterizing the radiosensitivity of both healthy and tumor tissues through specific MRI sequences. By generating 3D maps of intra-tumor radiosensitivity, the study seeks to optimize treatment plans and improve patient outcomes. The research is observational and focuses on patients diagnosed with various types of cancer who are receiving external radiotherapy.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older diagnosed with prostate, kidney, cervix, head and neck cancer, or glioblastoma who are indicated for external radiotherapy.
Not a fit: Patients who are unable to maintain a lying position during the procedure or those who are pregnant or breastfeeding may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to more personalized and effective radiotherapy treatments for cancer patients.
How similar studies have performed: While the use of MRI in radiotherapy is gaining traction, this specific approach combining AI and detailed radiosensitivity mapping is relatively novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18years old or older * diagnosed with prostate, kidney, cervix, head and neck cancer or glioblastoma * indication of external radiotherapy * treated with the Linac UNITY MRI guided radiotherapy at the centre hospitalier Lyon Sud des Hospices Civils de Lyon * agreement of the patient to participate * affiliated to a social security system Exclusion Criteria: patient unable to keep a lying position during all the procedure * patient under law restriction * pregnant women or breastfeeding
Where this trial is running
Lyon
- Hôpital Lyon Sud/ service de Radiothérapie Oncologie — Lyon, France (Recruiting)
Study contacts
- Study coordinator: Olivier CHAPET, MD
- Email: Olivier.chapet@chu-lyon.fr
- Phone: 4 78 86 42 51
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.