Long-term effects of NMDAR encephalitis
Social and Psychological Long-term Impact of NMDA Receptor Encephalitis, Level 3
This project will use online questionnaires to see if adults who had anti-NMDAR encephalitis experience lasting social, cognitive, or psychological problems.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Hospices Civils de Lyon Academic / other |
| Locations | 1 site (Bron) |
| Trial ID | NCT07158229 on ClinicalTrials.gov |
What this trial studies
This observational study collects patient-reported data using questionnaires to characterize long-term social and psychological outcomes after anti-NMDAR encephalitis. Adult patients (≥18) with confirmed NMDAR encephalitis who have internet access and are affiliated to a social security system are invited to participate. The study is coordinated by Hospices Civils de Lyon with collaboration from Charité University in Berlin and is conducted primarily via remote questionnaires. The goal is to fill gaps in knowledge about how the disease affects daily functioning and psychosocial well-being after the acute phase.
Who should consider this trial
Good fit: Adults (18 or older) with confirmed NMDAR encephalitis who are not under guardianship, are affiliated to a social security system, and can access the internet and a computer are ideal candidates.
Not a fit: People without NMDAR encephalitis, those under guardianship or curatorship, or those with neurological disorders predating the encephalitis are excluded and unlikely to benefit from this project.
Why it matters
Potential benefit: If successful, the results could identify lasting social and psychological needs and inform rehabilitation, support services, and follow-up care for survivors.
How similar studies have performed: A few cohort studies have reported persistent cognitive impairment after NMDAR encephalitis, but long-term psychosocial outcomes are still relatively untested and this project is addressing a novel evidence gap.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with NMDAR encephalitis * Age ≥ 18 years old * Patient affiliated to a social security system * No opposition from the patient * Access to an internet connection and a computer Exclusion Criteria: * Patients whithout NMDAR encephalitis * Patient under guardianship or curatorship * Patient with neurological disorders pre-existing encephalitis
Where this trial is running
Bron
- Centre de référence des syndromes neurologies paranéoplasiques et encéphalites auto-immunes - Hôpital neurologiques Pierre WERTHEIMER - Groupement hospitalier Est - Hospices civiles de Lyon — Bron, France (Recruiting)
Study contacts
- Study coordinator: Jérôme HONNORAT, Pr
- Email: jerome.honnorat@chu-lyon.fr
- Phone: 0472357806
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.