Examining the Aortic to Radial Pressure Gradient in Shock Conditions
Official title: Prevalence of the Aortic to Radial Pressure Gradient in States of Shock
Run by Hospices Civils de Lyon · NCT06460519 · Data updated 2026-11-12
This study looks at how pressure differences between arteries in patients experiencing shock can help doctors better manage their treatment while they are on medication to support blood pressure.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 99 Years |
| Sex | All |
| Enrollment | 180 (estimated) |
| Sponsor | Hospices Civils de Lyon Academic / other |
| Locations | 9 sites (Bron and 8 other locations) |
| Status | Recruiting |
| Started | October 3, 2024 |
| Main results expected | November 3, 2027 |
| Study ends | November 3, 2027 |
| Registry record updated | September 17, 2026 |
| Trial ID | NCT06460519 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older who are experiencing shock and require vasopressor support.
✕Probably not a fit
Patients who are undergoing cardiac surgery or are pregnant may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates the prevalence of the aortic to radial pressure gradient (ATRAP) in patients experiencing shock outside of cardiac surgery. It aims to measure the pressure differences between the radial and femoral arteries to understand the implications for vasopressor administration. The study includes patients who are on vasopressor support and have invasive blood pressure monitoring in place. By identifying the ATRAP, the research seeks to improve patient management in intensive care settings.
Why it matters
Potential benefit: If successful, this study could lead to better management of vasopressor therapy in patients with shock, potentially reducing hospital stays and side effects.
How similar studies have gone: While the ATRAP has been documented in septic shock, this specific observational approach is novel and has not been extensively tested in other contexts.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * age superior or equal 18 years * Vasopressors support superior or equal 0.5 µg/kg/min of equivalent norepinephrine * Invasive monitoring of blood pressure with a radial arterial catheter and a femoral arterial catheter decided by de physician * Beginning of the shock less than 48 hours. * Consent Exclusion Criteria: * perioperative of cardiac surgery (between the beginning of the surgery and 7 days after) * pregnant woman or breast-feeding * Major person under protection * Person with privation of liberty by a justice decision, or an administrative decision
Where it's running
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Département d'anesthésie Réanimation Hôpital Cardiologique Louis Pradel/Groupement Hospitalier Est
Bron, France Recruiting -
Département d'anesthésie-réanimation CHU de Clermont-Ferrand
Clermont-Ferrand, France Recruiting -
Service d'Anesthésie Association hospitalière Protestante de Lyon
Lyon, France Recruiting -
Hopital Edouard heriot/Groupement hospitalier Centre, service de médecine intensive réanimation
Lyon, France Recruiting -
Hôpital Edouard Heriot/ Groupement hospitalier Centre, service d'anesthésie réanimation
Lyon, France Recruiting -
Hôpital de la Croix-Rousse/Groupement hospitalier Nord, service d'anesthésie réanimation
Lyon, France Recruiting
Show 3 more locations
-
Hôpital Saint Joseph Saint Luc
Lyon, France Recruiting -
Centre hospitalier Lyon Sud/Groupement hospitalier Sud, Service d'anesthésie réanimation médecine intensive
Lyon, France Recruiting -
Service de réanimation médico-chirurgicale et traumatologique Centre Hospitalier Universitaire de la Guadeloupe
Les Abymes, Guadeloupe Recruiting
Study contacts
- Study coordinator: Matthias Jacquet-lagreze, Dr
- Email: matthias.jacquet-lagreze@chu-lyon.fr
- Phone: 0783426888
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Gastric emptying and feeding tolerance in ICU patients by vasopressor dose
This study tests whether vasopressor dose affects how well stomach contents empty during tube feeding in critically ill patients.
-
Argos system to track cardiac output changes in critically ill patients
This study tests whether the Argos monitor can reliably track how cardiac output changes after fluid administration or norepinephrine adjustments in critically ill adults already monitored with transpulmonary thermodilution.
-
Pulse palpation vs arterial blood pressure in circulatory shock
This study tests how well feeling for a pulse at typical sites matches the actual arterial blood pressure in adults with circulatory shock or risk of failure.
-
Femoral vein-to-artery diameter ratio to predict fluid responsiveness
This project will test whether a bedside ultrasound measurement of the femoral vein-to-artery diameter ratio can tell if mechanically ventilated ICU patients with acute circulatory failure or shock will increase their cardiac output after a 500 mL fluid bolus.
-
Right ventricular–arterial coupling during fluid loading in ICU patients
This study tests how the right ventricle handles fluid changes in critically ill adults to see how it affects blood flow and congestion.
-
Looking at tiny particles in cord blood of babies born before 28 weeks
The team will test whether extracellular vesicles in umbilical cord blood can help predict serious complications in babies born before 28 weeks of pregnancy.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.