Examining the Aortic to Radial Pressure Gradient in Shock Conditions
Prevalence of the Aortic to Radial Pressure Gradient in States of Shock
This study looks at how pressure differences between arteries in patients experiencing shock can help doctors better manage their treatment while they are on medication to support blood pressure.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 180 (estimated) |
| Ages | 18 Years to 99 Years |
| Sex | All |
| Sponsor | Hospices Civils de Lyon Academic / other |
| Locations | 6 sites (Bron and 5 other locations) |
| Trial ID | NCT06460519 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the prevalence of the aortic to radial pressure gradient (ATRAP) in patients experiencing shock outside of cardiac surgery. It aims to measure the pressure differences between the radial and femoral arteries to understand the implications for vasopressor administration. The study includes patients who are on vasopressor support and have invasive blood pressure monitoring in place. By identifying the ATRAP, the research seeks to improve patient management in intensive care settings.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who are experiencing shock and require vasopressor support.
Not a fit: Patients who are undergoing cardiac surgery or are pregnant may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better management of vasopressor therapy in patients with shock, potentially reducing hospital stays and side effects.
How similar studies have performed: While the ATRAP has been documented in septic shock, this specific observational approach is novel and has not been extensively tested in other contexts.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * age superior or equal 18 years * Vasopressors support superior or equal 0.5 µg/kg/min of equivalent norepinephrine * Invasive monitoring of blood pressure with a radial arterial catheter and a femoral arterial catheter decided by de physician * Beginning of the shock less than 48 hours. * Consent Exclusion Criteria: * perioperative of cardiac surgery (between the beginning of the surgery and 7 days after) * pregnant woman or breast-feeding * Major person under protection * Person with privation of liberty by a justice decision, or an administrative decision
Where this trial is running
Bron and 5 other locations
- Département d'anesthésie Réanimation Hôpital Cardiologique Louis Pradel/Groupement Hospitalier Est — Bron, France (Recruiting)
- Hopital Edouard heriot/Groupement hospitalier Centre, service de médecine intensive réanimation — Lyon, France (Recruiting)
- Hôpital Edouard Heriot/ Groupement hospitalier Centre, service d'anesthésie réanimation — Lyon, France (Recruiting)
- Hôpital de la Croix-Rousse/Groupement hospitalier Nord, service d'anesthésie réanimation — Lyon, France (Recruiting)
- Hôpital Saint Joseph Saint Luc — Lyon, France (Recruiting)
- Centre hospitalier Lyon Sud/Groupement hospitalier Sud, Service d'anesthésie réanimation médecine intensive — Lyon, France (Recruiting)
Study contacts
- Study coordinator: Matthias Jacquet-lagreze, Dr
- Email: matthias.jacquet-lagreze@chu-lyon.fr
- Phone: 0783426888
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.