Clinical trial Recruiting at 9 sites Observational Ages 18 to 99

Examining the Aortic to Radial Pressure Gradient in Shock Conditions

Official title: Prevalence of the Aortic to Radial Pressure Gradient in States of Shock

Run by Hospices Civils de Lyon · NCT06460519 · Data updated 2026-11-12

This study looks at how pressure differences between arteries in patients experiencing shock can help doctors better manage their treatment while they are on medication to support blood pressure.

More Shock trials

Quick facts

Study typeObservational
Ages18 Years to 99 Years
SexAll
Enrollment180 (estimated)
SponsorHospices Civils de Lyon
Academic / other
Locations9 sites (Bron and 8 other locations)
StatusRecruiting
StartedOctober 3, 2024
Main results expectedNovember 3, 2027
Study endsNovember 3, 2027
Registry record updatedSeptember 17, 2026
Trial IDNCT06460519 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18 and older who are experiencing shock and require vasopressor support.

Probably not a fit

Patients who are undergoing cardiac surgery or are pregnant may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the prevalence of the aortic to radial pressure gradient (ATRAP) in patients experiencing shock outside of cardiac surgery. It aims to measure the pressure differences between the radial and femoral arteries to understand the implications for vasopressor administration. The study includes patients who are on vasopressor support and have invasive blood pressure monitoring in place. By identifying the ATRAP, the research seeks to improve patient management in intensive care settings.

Why it matters

Potential benefit: If successful, this study could lead to better management of vasopressor therapy in patients with shock, potentially reducing hospital stays and side effects.

How similar studies have gone: While the ATRAP has been documented in septic shock, this specific observational approach is novel and has not been extensively tested in other contexts.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* age superior or equal 18 years
* Vasopressors support superior or equal 0.5 µg/kg/min of equivalent norepinephrine
* Invasive monitoring of blood pressure with a radial arterial catheter and a femoral arterial catheter decided by de physician
* Beginning of the shock less than 48 hours.
* Consent

Exclusion Criteria:

* perioperative of cardiac surgery (between the beginning of the surgery and 7 days after)
* pregnant woman or breast-feeding
* Major person under protection
* Person with privation of liberty by a justice decision, or an administrative decision

Where it's running

  • Département d'anesthésie Réanimation Hôpital Cardiologique Louis Pradel/Groupement Hospitalier Est
    Bron, France
    Recruiting
  • Département d'anesthésie-réanimation CHU de Clermont-Ferrand
    Clermont-Ferrand, France
    Recruiting
  • Service d'Anesthésie Association hospitalière Protestante de Lyon
    Lyon, France
    Recruiting
  • Hopital Edouard heriot/Groupement hospitalier Centre, service de médecine intensive réanimation
    Lyon, France
    Recruiting
  • Hôpital Edouard Heriot/ Groupement hospitalier Centre, service d'anesthésie réanimation
    Lyon, France
    Recruiting
  • Hôpital de la Croix-Rousse/Groupement hospitalier Nord, service d'anesthésie réanimation
    Lyon, France
    Recruiting
Show 3 more locations
  • Hôpital Saint Joseph Saint Luc
    Lyon, France
    Recruiting
  • Centre hospitalier Lyon Sud/Groupement hospitalier Sud, Service d'anesthésie réanimation médecine intensive
    Lyon, France
    Recruiting
  • Service de réanimation médico-chirurgicale et traumatologique Centre Hospitalier Universitaire de la Guadeloupe
    Les Abymes, Guadeloupe
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.