Whole-head helium-4 optically pumped magnetometer (OPM He4) brain scanner for faster brain recordings
Official title: Towards a New Generation of Magnetoencephalographs: Evaluation of the FYNA Research (Mag4Health 48 Sensors MEG's Name) System (Full-head Magnetoencephalographs System With Optically Pumped Magnetometers)
Run by Hospices Civils de Lyon · NCT06244472 · Data updated 2026-11-12
This project will test whether a new whole-head brain scanner using helium-4 sensors can pick up and map brain activity in healthy adults and athletes with mild concussion.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 70 Years |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | Hospices Civils de Lyon Academic / other |
| Locations | 2 sites (Bron and 1 other locations) |
| Status | Recruiting |
| Started | July 9, 2025 |
| Main results expected | August 2027 |
| Study ends | August 2027 |
| Registry record updated | June 1, 2026 |
| Trial ID | NCT06244472 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are motivated adults aged 18–70 who are either healthy volunteers or athletes with a history of mild concussion and who have no neurological, psychiatric, or MRI/MEG contraindications.
✕Probably not a fit
People with implanted metal devices or other MEG/MRI contraindications, pregnant women, those with major cognitive or psychiatric disorders, or legally protected/incarcerated individuals would not be expected to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional project uses a new generation of non-invasive magnetoencephalography (MEG) sensors based on helium-4 optically pumped magnetometers to record brain magnetic activity. Investigators will record responses in healthy volunteers during visual, auditory, somatosensory, motor, language, and rest tasks and will also record athletes who experienced a mild concussion. The main comparison is signal-to-noise ratio between the new OPM He4 MEG and a conventional MEG system, and a secondary comparison will test whether brain activity maps reconstructed from OPM He4 data match those from conventional MEG. All recordings are performed on-site at Hospices Civils de Lyon facilities using standardized tasks to permit direct device-to-device comparison.
Why it matters
Potential benefit: If successful, the new OPM He4 MEG could enable faster, more sensitive, and more flexible non-invasive brain recordings that improve detection and mapping of brain activity after concussion.
How similar studies have gone: Other optically pumped magnetometer MEG systems (mostly rubidium-based) have shown promising results in humans, but whole-head helium-4 OPM MEG is a novel approach with limited prior human data.
Who can join: the full rules
Show full inclusion / exclusion criteria
Healthy volunteers: Inclusion Criteria: * Age 18 to 70 * Strongly motivated to participate to the study * Signed informed consent for the study Exclusion Criteria: * major cognitive deficit and unable to understand the instructions * previous neurology or psychiatric or sleep pathologies * Woman with a positive pregnancy test during the inclusion. * Subjects under guardianship, curatorship or safeguard of justice protection * Subjects deprived of their liberty * Subject not affiliated to a social security system. * Subject's refusal to be informed if an abnormality is detected during MEG and MRI scans * Subject with common contraindications to MEG and MRI examination : * Metal in the body incompatible with performance of the examination (pacemaker, implantable pump, neurostimulator, cochlear implant, auditory prothesis, metalic prothesis, intracerebral clip, implantable defibrillator, any metalic parts in the brain or upper part of the body, ventriculoperitoneal valve, dental appliance or steel pivot for root canal, ferromagnetic foreign body in the upper part of the upper part of the body) * Claustrophobia Subjects who suffered a mild concussion: Inclusion Criteria: * Male aged from 18 to 40 * Strongly motivated to participate to the study * Signed informed consent for the study * Mild concussion confirmed by the club doctor and a neurologist neurologist in the three weeks preceding the experiment Exclusion Criteria: * major cognitive deficit and unability to understand the instructions * previous neurology or psychiatric or sleep pathologies except mild concussion * Woman with a positive pregnancy test during the inclusion. * Subjects under guardianship, curatorship or safeguard of justice protection * Subjects deprived of their liberty * Subject not affiliated to a social security system * Subject's refusal to be informed if an abnormality is detected during MEG and MRI scans * Subject with common contraindications to MEG and MRI examination : * Metal in the body incompatible with performance of the examination (pacemaker, implantable pump, neurostimulator, cochlear implant, auditory prothesis, metalic prothesis, intracerebral clip, implantable defibrillator, any metalic parts in the brain or upper part of the body, ventriculoperitoneal valve, dental appliance or steel pivot for root canal, ferromagnetic foreign body in the upper part of the upper part of the body) * Claustrophobia
Where it's running
-
Service de Neurologie Fonctionnelle et d'Epileptologie, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon
Bron, France Recruiting -
Centre Orthopédique Paul Santy
Lyon, France Not yet recruiting
Study contacts
- Principal investigator: Julien JUNG, MD — Service d'Epilepsie et Explorations fonctionnelles neurologiques,Hôpital Neurologique P. Wertheimer, Groupement Hospitalier Est, HCL
- Study coordinator: Julien JUNG, MD
- Email: julien.jung@chu-lyon.fr
- Phone: 04.72.35.79.00
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.