Attention capture by real-life episodic memories in healthy volunteers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study explores how episodic memory may shape attention control by leveraging real-life experiences generated via a mobile app. Participants perform tasks while eye movements are tracked and functional MRI measures DAN/VAN brain activity. The protocol includes encoding of old vs new objects and congruent vs incongruent contexts, followed by imaging to observe neural correlates of attention in relation to remembered episodes. Eligible participants are healthy adults aged 18–40 who are right-handed, without neurological or psychiatric conditions, and who can use a compatible smartphone and undergo MRI. The investigation aims to link memory-rich contexts with attentional control networks in the brain.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Be 18 years old to 40 years old
* Be right-handed
* Do not wear glasses
* Have a mobile-phone compatible with the application, minimum 6rd generation Android operating system, with geo-localization activated and accepted by the user
* Undertake to comply with the instructions and recommendations for MRI examination
* Provide informed written consent to participate in the study

Exclusion Criteria:

* History of known neurological or psychiatric illness
* Cognitive problems limiting the understanding of instructions
* Recent taking psychotropic drugs (antidepressants, anxiolytics, antipsychotics). The main treatments not authorized during this research are the following: Psychotropic treatments (drugs that can induce changes in perception, sensation, mood, consciousness or behavior). Like what:
* Antipsychotics (valproic acid, amisulpride, aripiprazole, clozapine, cyamemazin, haloperidol, loxapine, olanzapine, risperidone).
* Antidepressants (Amitriptyline, Citalopram, Clomipramine, Duloxetine, Escitalopam, Fluoxetine, Mianserine, Mirtazapine, Nortriptyline, Paroxetine, Sertraline, Venlafaxine).
* Anxyolitics
* Pregnant or breastfeeding women
* Persons deprived of their liberty by a judicial or administrative decision
* Persons admitted to a health or social institution for purposes other than research
* Adults subject to a legal protection measure (guardianship, curatorship)
* Persons not affiliated to a social security scheme or beneficiaries of a similar scheme
* Participation in another research study of the current study
* Contraindication for fMRI scanning
* Participant not agreeing to be informed in the event of the incidental discovery of an anomaly on MRI

  • For visit number 2 :
* Alcohol consumption (\> 3 drinks) in the 24h before the experiment
* Alcohol consumption the day of the experiment
* Cafeine consumption 1 hour or less before the experiment
* Drug consumption within the 24h preceding the experiment
* Antimalarial treatment within the 3 days preceding the experiment

Where it's running

• UCBL1, CRNL Inserm U1028, CNRS UMR5292, équipe IMPACT
  Bron, Rhone, France Recruiting

Study contacts

• Study coordinator: Emiliano MACALUSO, Pr
• Email: emiliano.macaluso@univ-lyon1.fr
• Phone: 04 72 91 34 07

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Effects of Exercise Snacks on Muscle Size and Strength in Healthy Young Adults

  This study tests whether many small workouts throughout the week can build muscle size and improve strength in healthy, untrained young adults compared with the usual twice-weekly workouts.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT07760597

• ORX489 safety and dosing in healthy adults ages 18 to 60

  This will test whether ORX489 tablets are safe, well tolerated, and how they are processed in the body in healthy men and women aged 18 to 60.

  Recruiting Phase 1 Centessa Pharmaceuticals (UK) Limited · Lincoln, Nebraska · NCT07413666

• ReHIIT Prehabilitation in Healthy Adults

  This pilot tests a combined resistance and high‑intensity interval training program to establish baseline physiology in healthy adults before applying findings to cancer patients.

  Recruiting University of Nottingham · Derby, Derbyshire · NCT07313332

• Safety and drug levels of a 3‑month naltrexone implant (BICX104) with or without bupropion versus monthly Vivitrol injections

  This will test whether a three‑month naltrexone implant (BICX104), given alone or with extended‑release bupropion, is safe and keeps steady drug levels compared with monthly Vivitrol injections in healthy adults.

  Recruiting Phase 1 BioCorRx Pharmaceuticals Inc · Miami, Florida · NCT07269873

• Compare two forms and doses of vonafexor and see if the high dose interacts with other drugs

  This test looks at how two doses and two formulations of vonafexor (EYP651 and vonafexor acid) are absorbed and processed in healthy adults and whether the high dose interacts with common medicines.

  Recruiting Phase 1 Enyo Pharma · Gières · NCT07251153

• Low-frequency vibrating mat for sleep and daily stress recovery

  This test will see if using a low-frequency vibrating mat at home for three weeks improves stress recovery, sleep quality, mood, and attention in healthy adults aged 18-45.

  Recruiting Florida International University · Miami, Florida · NCT07221318

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.