Interferon reference for older people (REFIPA)

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The project will recruit adults aged 80 and older without symptoms of active infection at Hôpital des Charpennes in Villeurbanne to collect blood samples and basic clinical information. Researchers will measure type I interferon levels and related immune markers to define baseline interferon response ranges in this age group. Those reference data will be compared with known patterns of active viral replication to determine whether interferon signals distinguish active from past infections. The goal is to develop a host-based diagnostic marker that complements PCR detection of viral genetic material.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Subject aged 80 or over
* Patient admitted to the Charpennes hospital day unit or outpatient clinic for follow-up OR accompanying patient who receive care at the Charpennes geriatric hospital OR subject recruited through the local press
* Weight greater than or equal to 45 kg
* Subject living in the Lyon metropolitan area

Exclusion Criteria:

* Subjects with symptoms of active infection (symptom questionnaire or temperature \> 37.5°C).
* Subjects with an autoimmune disease linked to a dysregulated interferon response.
* Subjects participating in another interventional study involving an exclusion period that is still ongoing or that may interfere with the present protocol.
* Subjects deprived of their liberty by judicial or administrative decision
* Subjects receiving psychiatric care
* Adults subject to legal protection measures (guardianship, curatorship)
* Subjects not affiliated with a social security scheme or beneficiaries of a similar scheme

Where it's running

• Hôpital des Charpennes (Hospices Civils de Lyon)
  Villeurbanne, France Recruiting

Study contacts

• Study coordinator: Antoine GARNIER-CRUSSARD
• Email: antoine.garnier-crussard@chu-lyon.fr
• Phone: +33 4 72 43 20 50

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.