Blood viscosity in ARDS: a look at how thick the blood is

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study compares blood viscosity and its determinants in adults with moderate-to-severe ARDS to a control group without ARDS. It collects blood samples from peripheral veins and from arterial/central lines to measure viscosity-related parameters. The goal is to see if hyperviscosity is present in ARDS and whether it correlates with respiratory and hemodynamic changes. The study is conducted at Hopital de la Croix-Rousse in Lyon under the Hospices Civils de Lyon as the lead sponsor. Participants include adults 18 and older with ARDS meeting specific criteria or eligible controls who consent to participate.

Why it matters

Who can join: the full rules

Case Group

Inclusion Criteria:

* Age ≥ 18 ans
* Moderate-to-severe ARDS according to the global definition:
* with PaO₂/FiO₂ ≤ 200 mmHg (based on arterial blood gas analysis in patients receiving invasive or non-invasive mechanical ventilation or high-flow nasal oxygen therapy).
* Participation agreement obtained (either from the patient themselves or from a relative)

Exclusion Criteria:

* ARDS that has been present for more than 72 hours
* Terminally ill patient with death expected within 24 hours
* Patient who has received a blood transfusion within the past month
* Patient with a known hematologic malignancy (lymphoma; myeloma; acute or chronic leukemia)
* Patient with a known hemoglobinopathy.
* Hemorrhagic shock
* Hemoglobin \< 70 g/dL

Control group

Inclusion Criteria:

* Age ≥ 18 ans
* Participation agreement obtained (either from the patient themselves or from a relative)

Exclusion Criteria:

* Presence of ARDS according to the global definition
* P/F \< 300 mmHg
* Presence of sepsis defined by an infection and a SOFA score delta ≥ 2.
* Terminally ill patient with death expected within 24 hours
* Patient who has received a blood transfusion within the past month
* Patient with a known hematologic malignancy (lymphoma; myeloma; acute or chronic leukemia)
* Patient with a known hemoglobinopathy.
* Hemorrhagic shock
* Hemoglobin \< 70 g/dL

Where it's running

• Hopital de la Croix-Rousse
  Lyon, France Recruiting

Study contacts

• Study coordinator: Hippolyte LEQUAIN, Dr
• Email: hippolyte.lequain@chu-lyon.fr
• Phone: 0472071281

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.