Nervous system study: sleep, seizures, and dreams in epilepsy with brain stimulation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the bidirectional relationship between sleep and epilepsy using simultaneous SEEG and polysomnography. Researchers will apply direct electrical stimulation during sleep in participants with focal temporal or frontal lobe epilepsy who are undergoing SEEG as part of presurgical evaluation. The aim is to see if nocturnal epileptic activity causes awakenings or sleep fragmentation and whether stimulation can modulate ictal or interictal activity without causing undue risk. Eligibility includes adults 18-55 with refractory focal epilepsy, undergoing SEEG with both frontal and temporal electrodes, and affiliated with the French healthcare system. No interventional outcomes are reported beyond the DES procedure within the sleep study context.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Written informed consent obtained from study subject and ability for study subject to comply with the requirements of the study
* Aged 18 to 55 years old
* Diagnosis of focal temporal or frontal lobe epilepsy based on non-invasive work-up
* Epilepsy is refractory to treatment, as defined by the International League Against Epilepsy 31
* Patients undergoing SEEG investigation
* At least 1 frontal and 1 temporal electrode in the SEEG procedure
* Patient affiliated to the French health care system

Exclusion Criteria:

* Multifocal epilepsy

  * Untreated severe obstructive sleep-apnea syndrome
  * Too abnormal SEEG recording interfering with sleep stage identification during the DES procedure
  * Severe cognitive impairment preventing full understanding and completion of the protocol
  * Unstable psychiatric condition
  * Subject participating in other interventional research with an exclusion period still in progress at pre-inclusion
  * Persons deprived of their liberty by a judicial or administrative decision
  * Adults subject to a legal protection measure (guardianship, curatorship
  * Persons not affiliated to a social security scheme or beneficiaries of a similar scheme

Where it's running

• Service de Neurologie Fonctionnelle et d'Epileptologie Hôpital Neurologique, GHE, Hospices Civils de Lyon Hôpital Neurologique Pierre WERTHEIMER
  Bron, France Recruiting
• Epilepsy Department, Duke University Hospital
  Durham, North Carolina, United States Not yet recruiting

Study contacts

• Study coordinator: PETER-DEREX MD Laure, MD
• Email: laure.peter-derex@chu-lyon.fr
• Phone: +33 (0) 4 72 35 70 44

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Temporal Interference Brain Stimulation for adults with drug-resistant focal epilepsy during stereo-EEG monitoring

  This study tests whether a non-invasive Temporal Interference brain stimulation can reduce abnormal brain activity in adults with drug-resistant focal epilepsy who are undergoing stereo-EEG monitoring.

  Recruiting Duke University · Durham, North Carolina · NCT07764718

• Impact of the brain’s adenosine pathway on epilepsy and arousal in adults

  This study tests how the brain’s adenosine system affects arousal and breathing in adults with drug-resistant focal epilepsy compared with healthy volunteers.

  Recruiting Hospices Civils de Lyon · Bron · NCT07249034

• Collection of blood and brain tissue samples from patients with drug-resistant epilepsy

  This study is collecting blood and brain tissue samples from adults with drug-resistant epilepsy who are having surgery to help researchers find new ways to understand and treat the condition.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT06022055

• Genetic and electrophysiologic analysis in children with drug-resistant epilepsy

  This study is testing if certain genetic changes in the brain are linked to drug-resistant epilepsy in children to help us understand why these conditions happen.

  Recruiting Fondation Ophtalmologique Adolphe de Rothschild · Paris · NCT02890641

• Modified ketogenic diet for adults with drug-resistant epilepsy

  This study tests whether a modified ketogenic diet can help adults with drug-resistant epilepsy see fewer seizures and feel better overall.

  Recruiting Karolinska Institutet · Stockholm · NCT07878104

• Non-Invasive Low Intensity Focused Ultrasound Stimulation for Drug-Resistant Epilepsy

  This study tests whether low intensity focused ultrasound can help reduce seizures in adults with drug‑resistant epilepsy.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07680842

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.