Using chest bioreactance to improve fluid therapy in lung surgery
Official title: Advanced Goal-Directed Impedancemetry Strategy for Lung Resection Surgery : a Multicenter, Randomized, Controlled Trial (AEGIS Study)
Run by Hospices Civils de Lyon · NCT06156943 · Data updated 2026-11-12
This study tests if using a new chest monitoring device can help doctors give better fluid treatment to patients having lung surgery, compared to the usual care.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 722 (estimated) |
| Sponsor | Hospices Civils de Lyon Academic / other |
| Locations | 10 sites (Bron and 9 other locations) |
| Status | Recruiting |
| Started | December 12, 2024 |
| Main results expected | January 2027 |
| Study ends | January 2027 |
| Registry record updated | December 24, 2024 |
| Trial ID | NCT06156943 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 and older with high-risk profiles undergoing elective lung resection surgery.
✕Probably not a fit
Patients undergoing emergency surgeries or those with specific exclusion criteria such as pleural or mediastinal resection surgery will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the use of chest bioreactance technology to monitor stroke volume and cardiac output in high-risk patients undergoing lung resection surgery. The study aims to implement individualized goal-directed fluid therapy (GDFT) based on real-time monitoring, contrasting it with standard care practices. By utilizing a non-invasive and continuous monitoring approach, the trial seeks to enhance perioperative management and outcomes for patients facing complex thoracic surgeries.
Why it matters
Potential benefit: If successful, this approach could lead to improved fluid management and better surgical outcomes for high-risk lung surgery patients.
How similar studies have gone: While the use of chest bioreactance is a relatively novel approach in this context, other studies have shown promise in utilizing non-invasive monitoring techniques for fluid management.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults (≥ 18 years old) * High-risk patients (ASA score ≥ 3 and/or ventilatory deficit (defined as FEV1≤70% and/or VC≤70%) and/or AKI risk index ≥ III and/or modified clinical Lee Criteria ≥2) undergoing elective open-chest or video-assisted or robotic lung resection surgery * Patients who have provided written informed consent to participate in the study * Patients affiliated with a social health insurance Exclusion Criteria: * Pleural or mediastinal resection surgery * Emergency surgery (Less than 24h) * Patients unable to understand the purpose of the study * Patients participating in another trial that would interfere with this study * Female patients who are pregnant, lactating or women of child-bearing potential without effective methods of contraception * Female patients with positive β-HCG blood test * Patients under judicial protection (guardianship, curatorship)
Where it's running
-
Hopital Louis Pradel
Bron, France Recruiting -
CHU Dijon Bourgogne
Dijon, France Recruiting -
Hôpital Arnaud de Villeneuve - CHU Montpellier
Montpellier, France Recruiting -
Chu Nancy
Nancy, France Recruiting -
Hôpital Européen Georges Pompidou
Paris, France Recruiting -
Hopital du Haut-Leveque - CHU Bordeaux
Pessac, France Recruiting
Show 4 more locations
-
CHU de Rennes
Rennes, France Recruiting -
CHU Nantes
Saint-Herblain, France Recruiting -
CHU Strasbourg
Strasbourg, France Recruiting -
Chu Toulouse
Toulouse, France Recruiting
Study contacts
- Study coordinator: FELLAHI Jean-Luc, M.D., Ph.D.,
- Email: jean-luc.fellahi@chu-lyon.fr
- Phone: (+33) 4 72 11 89 33
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.