Remote conditioning for patients after out-of-hospital cardiac arrest
REmote Ischemic COnditioning in Out-of-Hospital Cardiac Arrest: The RECO-OHCA Study
This study tests if a new treatment called remote ischemic conditioning can help protect organs and improve survival for patients who have had a cardiac arrest outside of the hospital.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 220 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Hospices Civils de Lyon Academic / other |
| Locations | 14 sites (Bron and 13 other locations) |
| Trial ID | NCT06306625 on ClinicalTrials.gov |
What this trial studies
This trial investigates the use of remote ischemic conditioning as a therapeutic strategy for patients who have experienced out-of-hospital cardiac arrest. The approach aims to protect organs from damage caused by ischemia-reperfusion injury, which is a significant factor in mortality and poor neurological outcomes following such events. Participants will either receive remote ischemic conditioning or standard care, and the study will assess its effectiveness in reducing mortality and organ failure. The trial focuses on patients hospitalized in critical care shortly after their cardiac arrest.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 80 who have experienced an out-of-hospital cardiac arrest and are admitted to critical care within three hours.
Not a fit: Patients with traumatic cardiac arrest or those for whom resuscitation is deemed unjustified will not benefit from this study.
Why it matters
Potential benefit: If successful, this intervention could significantly reduce mortality and improve neurological outcomes for patients who suffer from out-of-hospital cardiac arrest.
How similar studies have performed: While the concept of remote ischemic conditioning is established, this specific application in out-of-hospital cardiac arrest is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age between 18 and 80 years old * Out-of-hospital cardiac arrest, whatever the initial cardiac rhythm (shockable or non-shockable) or the duration of no-flow and low-flow, * Presence of a witness who may or may not have started cardiopulmonary resuscitation, or patient seen alive in the 30 minutes prior to the cardiac arrest, * Hospitalisation in critical care (intensive care unit or cardiac intensive care unit) for less than 3 hours, * Informed consent obtained from a close relative (exceptionally from the patient himself if his condition permits) or, failing this, use of the emergency procedure by the investigator. Exclusion Criteria: * Traumatic cardiac arrest * Patient on extracorporeal circulatory assistance * Cardiac arrest for which continuation of resuscitation does not appear justified (unavoidable death, terminal stage of an irreversible disease, etc.) * Contraindication of the use of brachial cuff on both arms (arteriovenous fistula, lymphoedema or severe peripheral vascular pathology, unstable humeral fracture, continuous infusion into an upper limb vein of an essential drug such as a catecholamine, radial arterial catheter for continuous invasive measurement of blood pressure) * Pregnant, parturient, or breast-feeding women * Patients deprived of their liberty by a judicial or administrative decision, * Patients under legal protection (guardianship, curatorship), * Patient not affiliated to a social security scheme or beneficiary of a similar scheme, * Previous inclusion in the study, * Subject participating in other interventional research that may interfere with the present study according to the investigator's judgement or that includes an exclusion period still in progress at inclusion
Where this trial is running
Bron and 13 other locations
- Hôpital Louis Pradel — Bron, France (Not_yet_recruiting)
- Hôpital Gabriel Montpied, CHU de Clermont Ferrand — Clermont-Ferrand, France (Not_yet_recruiting)
- Centre Jean Perrin, Clermont-Ferrand — Clermont-Ferrand, France (Not_yet_recruiting)
- Hôpital F Mitterrand, CHU de Dijon — Dijon, France (Not_yet_recruiting)
- Hôpital Albert Michallon, CHU de Grenoble — La Tronche, France (Not_yet_recruiting)
- Hôpital Edouard Herriot — Lyon, France (Recruiting)
- Hôpital Saint-Joseph Saint-Luc — Lyon, France (Recruiting)
- Hôpital de la Timone, CHU de Marseille — Marseille, France (Recruiting)
- Hôpital lapeyronie, CHU de Montpellier — Montpellier, France (Recruiting)
- Hôpital Universitaire Carémeau — Nîmes, France (Not_yet_recruiting)
- Hôpital Lariboisière, APHP, Réanimation Médicale et Toxicologique — Paris, France (Not_yet_recruiting)
- Hôpital Lyon-Sud — Pierre-Bénite, France (Recruiting)
- Hôpital Nord, CHU de St Etienne — Saint-Priest-en-Jarez, France (Recruiting)
- Hôpital Nord-Ouest — Villefranche-sur-Saône, France (Recruiting)
Study contacts
- Study coordinator: Marie-Line Harlay
- Email: marie-line.harlay@chu-lyon.fr
- Phone: 04 72 11 28 62
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.