Remote conditioning for patients after out-of-hospital cardiac arrest

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial investigates the use of remote ischemic conditioning as a therapeutic strategy for patients who have experienced out-of-hospital cardiac arrest. The approach aims to protect organs from damage caused by ischemia-reperfusion injury, which is a significant factor in mortality and poor neurological outcomes following such events. Participants will either receive remote ischemic conditioning or standard care, and the study will assess its effectiveness in reducing mortality and organ failure. The trial focuses on patients hospitalized in critical care shortly after their cardiac arrest.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age between 18 and 80 years old
* Out-of-hospital cardiac arrest, whatever the initial cardiac rhythm (shockable or non-shockable) or the duration of no-flow and low-flow,
* Presence of a witness who may or may not have started cardiopulmonary resuscitation, or patient seen alive in the 30 minutes prior to the cardiac arrest,
* Hospitalisation in critical care (intensive care unit or cardiac intensive care unit) for less than 3 hours,
* Informed consent obtained from a close relative (exceptionally from the patient himself if his condition permits) or, failing this, use of the emergency procedure by the investigator.

Exclusion Criteria:

* Traumatic cardiac arrest
* Patient on extracorporeal circulatory assistance
* Cardiac arrest for which continuation of resuscitation does not appear justified (unavoidable death, terminal stage of an irreversible disease, etc.)
* Contraindication of the use of brachial cuff on both arms (arteriovenous fistula, lymphoedema or severe peripheral vascular pathology, unstable humeral fracture, continuous infusion into an upper limb vein of an essential drug such as a catecholamine, radial arterial catheter for continuous invasive measurement of blood pressure)
* Pregnant, parturient, or breast-feeding women
* Patients deprived of their liberty by a judicial or administrative decision,
* Patients under legal protection (guardianship, curatorship),
* Patient not affiliated to a social security scheme or beneficiary of a similar scheme,
* Previous inclusion in the study,
* Subject participating in other interventional research that may interfere with the present study according to the investigator's judgement or that includes an exclusion period still in progress at inclusion

Where it's running

• Hôpital Edouard Herriot
  Lyon, France Recruiting
• Hôpital Saint-Joseph Saint-Luc
  Lyon, France Recruiting
• Hôpital de la Timone, CHU de Marseille
  Marseille, France Recruiting
• Hôpital lapeyronie, CHU de Montpellier
  Montpellier, France Recruiting
• Hôpital Lyon-Sud
  Pierre-Bénite, France Recruiting
• Hôpital Nord, CHU de St Etienne
  Saint-Priest-en-Jarez, France Recruiting

Study contacts

• Study coordinator: Marie-Line Harlay
• Email: marie-line.harlay@chu-lyon.fr
• Phone: 04 72 11 28 62

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Early double sequential defibrillation for cardiac arrest outside the hospital

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• Prehospital access to extracorporeal cardiopulmonary resuscitation in Prague

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• Initial double sequential defibrillation for out-of-hospital ventricular fibrillation

  This trial will test whether using two defibrillators to give double sequential shocks first improves survival for adults with out-of-hospital cardiac arrest and a shockable rhythm.

  Recruiting St. Olavs Hospital · Trondheim · NCT06672159

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.