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Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Non-invasive ventilation versus high-flow oxygen for recent chest trauma

Official title: Effects of Non-invasive Ventilation and High-flow Oxygen Therapy on the Lung in Hypoxemic Chest Trauma Patients, a Descriptive Experimental CT Scan Study

Run by Hospices Civils de Lyon · NCT06735872 · Data updated 2026-11-12

We will try a 10-minute session of non-invasive ventilation or high-flow oxygen and then do a CT scan to see how each affects the lungs of adults hospitalized with hypoxemic chest trauma.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment30 (estimated)
SponsorHospices Civils de Lyon
Academic / other
Locations1 site (Lyon, Rhône)
StatusRecruiting
StartedApril 22, 2025
Main results expectedApril 22, 2027
Study endsApril 22, 2027
Registry record updatedJune 24, 2025
Trial IDNCT06735872 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adult ICU patients within five days of chest trauma who have at least three rib fractures on initial CT and require moderate supplemental oxygen (SpO2 ≥ 92% or PaO2/FiO2 > 200) and who are scheduled for a chest CT are ideal candidates.

Probably not a fit

Patients who are intubated or in respiratory failure (PaO2/FiO2 ≤ 200 or clear indications for intubation), those with severe hypoxemia or inability to tolerate the breath-hold required for CT, or those outside the early post-trauma window are unlikely to benefit from participation.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults admitted to ICU within five days of blunt chest trauma who have at least three rib fractures and moderate oxygen needs are randomly assigned to a 10-minute session of non-invasive ventilation (NIV) or high-flow oxygen (HFO). A chest CT is performed immediately after the session to directly image short-term changes in lung aeration and contusion. The protocol focuses on physiologic imaging endpoints rather than longer-term clinical outcomes such as intubation or length of stay. Investigators designed the approach because prior NIV studies are older and underpowered and HFO has very limited data in chest trauma.

Why it matters

Potential benefit: If successful, the findings could clarify which short-term respiratory support better improves lung aeration after chest trauma and help guide early therapy choices.

How similar studies have gone: Some older, small trials suggested NIV can avoid intubation and shorten stays in hypoxemic chest trauma, but the evidence is underpowered and HFO has only minimal study in this setting.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Age \> 18 years old
* Chest trauma \< 5 days
* At least 3 ribs fracture on initial CT-scan
* Need of oxygen moderated to maintain monitoring oxygen saturation Sp02 \> 92% or partial pressure of arterial oxygen Pa02/ Fraction of inspired oxygen FiO2 \> 200
* Intensive Care Unit admission
* Need a chest CT control during the five first days after the trauma

Exclusion Criteria:

* Patient intubated or with respiratory failure : measured or estimated Pa02/FiO2 \< 200 or indication for intubation (several with respiratory rate \> 35/min, abundant tracheal secretions, significant increase in work of accessory respiratory muscles on inspiration, signs of respiratory exhaustion on arterial blood gas with The potential of Hydrogen pH \< 7,3 or PaCO2 \> 50 mmHg, severe hypoxemia with PaO2/FiO2 ratio \< 100 or desaturation \< 88% for more than 5 minutes)

  * Inability to maintain 10 seconds of apnoea required for scan acquisition
  * Patient treated with ventilatory support by NIV or HFO in the 12 hours prior the investigation
  * Uncontrolled circulatory failure with need for introduction of Noradrenaline \> 0,15 ug/kg/min
  * Uncontrolled neurological failure with Glasgow Coma Scale (CGS \< 15
  * Unstable facial trauma or with pneumocephalus or basilar skull trauma
  * Large, undrained pneumothorax with lateral separation at the level of the hilum \> 2 cm and extensive throughout the axillary line
  * Patients with identified cognitive impairment
  * Persons deprived of liberty, persons under protective measures
  * Persons not affiliated to a social security insurance
  * Current pregnancy or breastfeeding
  * Refusal to participate in the study

Where it's running

  • Hopital Edouard Herriot
    Lyon, Rhône, France     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.