Feasibility of using a weight-adjusted saline bolus with electrical impedance tomography to map lung perfusion in children

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot study explores the feasibility of using electrical impedance tomography (EIT) to assess regional lung perfusion and ventilation in children on invasive mechanical ventilation. A weight-adjusted hypertonic saline bolus is used during EIT to visualize perfusion distribution and the ventilation/perfusion ratio, aiming to adapt adult perfusion protocols for pediatric patients. Eligible participants are under 12 years old, mechanically ventilated, and have central venous access, with a strict exclusion set to minimize risk. The study is conducted at an institution led by Hospices Civils de Lyon in France, focusing on safety, image quality, and practicality of this approach in a pediatric ICU setting.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* patients \< 12 years hospitalized in pediatric intensive care
* intubated, under conventional invasive mechanical ventilation and sedated
* between 3 and 40 kg
* with central venous access in the superior vena cava
* consent signed by parents or legal guardians

Exclusion Criteria:

* Patients with significant leaks \> 20% around the endotracheal tube
* Patients receiving spontaneous ventilation (inspiratory support, NIV, etc.)
* Natremia \> 150 mmol/L at inclusion
* Hyperchloremia ≥ 115 mmol/L and/or hypokaliema ≤ 3 mmol/L
* Patients with intracranial hypertension
* Patients with active bleeding or persistent hemodynamic instability despite amines
* Patients with heart failure, uncorrected cyanotic heart disease, or a history of cardiac arrhythmia
* Patients with contraindications to the use of the electrical impedance pulmonary tomography belt (skin lesions, burns, or recent thoracic surgery)
* Conditions in which EIT data acquisition will be disrupted (chest dressings, pneumothorax, ECMO)
* Patients with severe hypoxemia defined as FiO2 \> 90% to maintain SpO2 \> 88%
* Individuals not affiliated with a social security system or beneficiaries of a similar system

Where it's running

• Florent BAUDIN
  Bron, France, France Recruiting

Study contacts

• Study coordinator: Florent BAUDIN, Pr
• Email: florent.baudin@chu-lyon.fr
• Phone: 04 72 12 97 05

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.