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Clinical trials and research at Brigham and Women's Hospital

• 156Clinical trials
• 1351NIH research projects
• 1New in 30 days
• 5Countries

Newest trials

All recruiting trials (newest 150 of 156)

• One-day exercise test to see how brain and body react in epilepsy, cognitive disorders, Parkinson's, dementia, and related conditions

  A one-day study tests how an acute bout of exercise changes brain function and bodily signals in people with certain neurological conditions compared with healthy individuals.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT07883720

• Training Independent Muscle Activation From a Common Source

  A new surgical approach plus home training tests whether people with recent amputations or revision surgeries can gain improved muscle control.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT07831278

• Activity after Spinal Surgery Engagement

  This trial tests whether a behavioral program helps people recover by being more physically active after lumbar spine decompression surgery.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT07825480

• Reach and Engagement of Genetic Education, Risk Assessment, and Testing Feasibility (GENET) for PDAC risk

  This study tests whether online education plus a phone call from PanCAN helps Black, Latino/a, and Medicaid-enrolled people in Massachusetts learn about genetic and multi-cancer early detection testing and decide about getting tested.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT07787156

• Burnout and Safety in Home Hospital vs Brick-and-Mortar Hospitals

  This study tests whether frontline clinicians in home hospital programs experience different burnout levels and workplace violence than those in traditional inpatient hospitals.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT07773168

• Tonsillectomy Added to Hypoglossal Nerve Stimulation for OSA with Lateral Wall Collapse

  In adults with obstructive sleep apnea and side-wide airway collapse, this study tests whether adding tonsil removal to hypoglossal nerve stimulation helps more than hypoglossal nerve stimulation alone.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT07724938

• Face photos test to measure biological aging with AI for healthy adults

  Researchers will use FaceAge, an AI-based tool that estimates biological age from a frontal face photo, to see how its estimates vary over time in healthy adults and what factors might influence them.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT07719049

• Transcutaneous Auricular Vagus Nerve Stimulation for Rosacea

  A small, single-arm pilot study will test whether taVNS can help adults with rosacea and moderate flushing or redness.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT07600424

• Combined upper-airway electrical stimulation with a drug combo for sleep apnea

  This study tests whether adding a drug mix called AtoOxy to an existing hypoglossal nerve stimulation device helps people with sleep apnea sleep better.

  Recruiting Phase 1/2 Brigham and Women's Hospital · Boston, Massachusetts · NCT07577661

• Using [64Cu]FBP8 PET/MR to find intracardiac blood clots in cardiac amyloidosis

  We'll test whether a [64Cu]FBP8 PET/MR scan can find blood clots inside the heart of people with cardiac amyloidosis who have atrial fibrillation or atrial flutter.

  Recruiting Phase 3 Brigham and Women's Hospital · Boston, Massachusetts · NCT07560306

• Stable Pilates for hypermobility symptoms

  This study tests whether six weeks of Pilates-led by a licensed physical therapist can reduce pain and related symptoms in adults with hypermobility conditions like hEDS/HSD.

  Recruiting Brigham and Women's Hospital · Chestnut Hill, Massachusetts · NCT07464093

• ROPES: an opioid-free discharge approach for robotic prostatectomy

  We are testing whether a standardized multimodal pain plan without an automatic opioid prescription helps men having robotic-assisted prostate removal use fewer opioids after surgery.

  Recruiting at 2 sites Phase 3 Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT07427043

• EpiFaith Syringe Learning Curve in Labor Epidurals

  This study tests whether the EpiFaith syringe helps anesthesia residents learn to place labor epidurals faster with fewer attempts.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT07395622

• Androgen-guided PSMA-PET-boost for prostate cancer treated with ADT and SBRT

  This study tests whether using PSMA-PET imaging during hormone therapy can help doctors target remaining cancer with a focused SBRT boost in men with intermediate- or high-risk prostate cancer.

  Recruiting at 2 sites Phase 2 Brigham and Women's Hospital · Boston, Massachusetts and 3 other locations · NCT07393867

• Using MyHealthPal to track wound healing after spinal or intrathecal pump surgery

  This project tries a smartphone app that lets adults who had spinal cord stimulator or intrathecal pump procedures send photos of their surgical wound so clinicians and an AI can watch for early infection.

  Recruiting Brigham and Women's Hospital · Chestnut Hill, Massachusetts · NCT07391735

• Tailored AI Guidelines for Heart Failure Care

  A large language model–based decision-support tool tests whether it helps cardiology clinicians improve guideline-directed heart failure therapy for adults in outpatient clinics.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT07337577

• Dapagliflozin added to standard care for active lupus nephritis

  A 12-week pilot trial will test whether adding dapagliflozin to standard lupus nephritis treatment helps people with active disease.

  Recruiting at 2 sites Phase 4 Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT07323524

• Coronary calcium and high-sensitivity troponin testing in people with rheumatoid arthritis

  This study will test whether measuring coronary artery calcium and high-sensitivity troponin can find people with rheumatoid arthritis who should start cholesterol-lowering treatment even if general risk calculators don't recommend it.

  Recruiting at 3 sites Brigham and Women's Hospital · Boston, Massachusetts and 2 other locations · NCT07315997

• Rosuvastatin to help prevent blood clots in cancer patients

  This study tests whether taking rosuvastatin daily for a year can lower the chance of dangerous blood clots in people with newly diagnosed or relapsed cancer who aren’t planned to receive blood-thinning medicine.

  Recruiting at 7 sites Phase 4 Brigham and Women's Hospital · Irvine, California and 8 other locations · NCT07303816

• Screening and predicting outcomes for brain-related vision problems in newborns

  This project will see if advanced brain imaging and scheduled follow-up can identify and predict cerebral/cortical visual impairment (CVI) in newborns born very preterm or who had hypoxic-ischemic encephalopathy or perinatal stroke.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT07275021

• Ropeginterferon for High Risk JAK2 Clonal Hematopoiesis in Adults

  This study tests whether ropeginterferon alfa-2b given as injections every 4 weeks is safe and feasible for adults with JAK2 V617F clonal hematopoiesis who have high-risk features but do not yet have myeloproliferative neoplasm.

  Recruiting Phase 1 Brigham and Women's Hospital · Boston, Massachusetts · NCT07249840

• Targeted accelerated transcranial magnetic stimulation for PTSD

  This trial will test whether short, imaging-guided accelerated transcranial magnetic stimulation (aTMS) can quickly reduce PTSD symptoms in adults with moderate-to-severe PTSD.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT07245641

• Self-adjusted nitrous oxide versus placebo during in-office vasectomy

  This will see if self-administered low-dose nitrous oxide (20–45%) helps reduce anxiety, catastrophizing, and pain for adults having an in-office vasectomy.

  Recruiting Early Phase 1 Brigham and Women's Hospital · Boston, Massachusetts · NCT07245628

• Restoring consciousness using deep brain stimulation of the central thalamus

  This trial will test whether deep brain stimulation of two specific central thalamus targets can help people with chronic disorders of consciousness become more responsive.

  Recruiting Early Phase 1 Brigham and Women's Hospital · Boston, Massachusetts · NCT07228286

• Sparsentan for high-grade proteinuria linked to VEGF inhibitors

  This pilot study tests whether sparsentan can reduce severe proteinuria in adults with cancer who are being treated with VEGF signaling pathway inhibitors.

  Recruiting Phase 1 Brigham and Women's Hospital · Boston, Massachusetts · NCT07224776

• How kidney transplant affects blood flow in the heart's tiny vessels in people with advanced CKD

  This study will try to see if getting a kidney transplant improves blood flow in the small vessels of the heart for people with advanced chronic kidney disease who are on the transplant waitlist.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT07222683

• Menstrual cup for early detection of endometrial cancer in Lynch syndrome

  This project will test whether using a menstrual cup can collect uterine lining samples that help detect early endometrial cancer in menstruating people who carry Lynch syndrome gene changes.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT07220239

• Preoperative 3D fracture analysis for planning tibial fixation

  This project will try a 3D CT-based tool that helps surgeons plan screw and plate fixation for adults with complex tibial plateau fractures to see if it fits into usual care.

  Recruiting at 2 sites Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT07193524

• Quality of life after atrial fibrillation following heart surgery

  This project will see how atrial fibrillation that starts after heart surgery affects quality of life in adults having cardiac operations.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT07173998

• Digital CBT versus nightly trazodone versus nightly daridorexant for menopause-related insomnia

  This project will see if online cognitive behavioral therapy, nightly trazodone, or nightly daridorexant helps people in peri- and post-menopause who are having insomnia.

  Recruiting at 4 sites Phase 4 Brigham and Women's Hospital · Boston, Massachusetts and 4 other locations · NCT07136415

• Same-day stereotactic radiation with reduced planning margins for growing or changing brain metastases

  This trial will try to see if doing MRI planning and stereotactic radiation on the same day, with either a 0 mm or 1 mm treatment margin, helps adults with growing or unstable brain metastases stay on target and reduce side effects.

  Recruiting Phase 2 Brigham and Women's Hospital · Boston, Massachusetts · NCT07132190

• Preventing first seizures with levetiracetam in patients with motor cortex brain metastases

  This test will try giving levetiracetam to adults with motor cortex brain metastases who have never had a seizure to see if it prevents a first seizure compared with not giving the drug.

  Recruiting Phase 2 Brigham and Women's Hospital · Boston, Massachusetts · NCT07130786

• Open-label oral treprostinil for Raynaud's

  This trial will test whether oral sustained-release treprostinil (UT-15C) can reduce the number and severity of Raynaud's attacks in adults with frequent primary or secondary Raynaud's.

  Recruiting Phase 4 Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT07112183

• Measuring brain glucose use in MS with FDG-PET

  This trial will test whether FDG-PET scans can detect different patterns of brain glucose use in people with progressive MS, relapsing-remitting MS, and healthy volunteers.

  Recruiting Phase 4 Brigham and Women's Hospital · Boston, Massachusetts · NCT07087106

• IntelliWell: AI imaging to find ultra-rare sperm in testicular tissue

  This will try an AI-assisted imaging platform to find rare sperm in testicular samples from men with non-obstructive azoospermia when standard processing finds no sperm.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT07074015

• How different CPAP mask exhaust flows affect CO2 rebreathing

  This test will see if different CPAP mask exhaust flows change how much exhaled carbon dioxide people with moderate to severe OSA might rebreathe during sleep.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT07062770

• Self-regulation of brain activity using real-time fMRI for fibromyalgia pain

  See if real-time fMRI neurofeedback combined with either cognitive behavioral therapy or fibromyalgia education helps adults with fibromyalgia learn to control brain responses and reduce pain.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT07023523

• Nicotinamide Mononucleotide for patients undergoing cardiac surgery

  This study tests whether taking NMN by mouth before and after heart surgery helps protect the heart and kidneys in adults at risk of complications.

  Recruiting Phase 2 Brigham and Women's Hospital · Boston, Massachusetts · NCT07013591

• Improving sleep and mindfulness for older adults in residential facilities

  This study is testing a new program to help older adults in residential facilities improve their sleep and mindfulness to see if it makes them feel better overall.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06989619

• Practical geriatric assessment for older adults with early-stage non-small cell lung cancer receiving SBRT

  This project will test whether a brief Practical Geriatric Assessment (PGA) can be used with adults 65+ who have stage I–II non-small cell lung cancer and are receiving stereotactic body radiation therapy to identify care needs and guide supportive referrals.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06987890

• Routine saline flushing to prevent nephrostomy tube obstructions

  This pilot will try routine saline flushing versus no routine flushing in adults with nephrostomy tubes to see if flushing prevents tube obstructions.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06987877

• Bedtime mindfulness meditation for chronic trouble falling asleep

  This pilot will test whether a 4-week bedtime mindfulness app helps adults with chronic trouble falling asleep compared with an unguided meditation app or sleep hygiene education.

  Recruiting Phase 1/2 Brigham and Women's Hospital · Boston, Massachusetts · NCT06972303

• Accelerated TMS for perinatal and postpartum depression

  This project will test whether an accelerated course of TMS (multiple sessions per day over five days) can help pregnant and postpartum people with major depressive disorder.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06968390

• Fezolinetant to reduce hot flashes in men on androgen-deprivation therapy

  This trial will test whether taking fezolinetant once daily for 4 weeks reduces how often and how severe hot flashes are in men with prostate cancer who are on androgen-deprivation therapy.

  Recruiting Phase 2 Brigham and Women's Hospital · Boston, Massachusetts · NCT06957691

• Yoga to reduce persistent pain after torso surgery

  This pilot will try a tailored yoga program versus chronic pain health education to see if yoga reduces persistent post-surgical torso pain in adults who still have pain three months or more after surgery.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06949007

• Comparing visual search behavior in mixed versus blocked tasks

  This study tests how people's ability to find things changes when they do the same search task over and over compared to when they have to switch between different tasks.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06934213

• Losartan to help recovery after multi-ligament knee injury

  This study tests whether a 30-day course of losartan helps people who have surgery for multi-ligament knee injuries regain motion, strength, and return to duty or sport within a year.

  Recruiting Phase 2 Brigham and Women's Hospital · Lexington, Kentucky and 2 other locations · NCT06933706

• Comparing mixed and blocked visual search tasks

  This study tests how doing the same visual search task over and over compares to mixing different tasks to see which way helps people pay attention better.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06933693

• Colchicine to Reduce Inflammation and Joint Symptoms in CPPD Disease

  This study tests whether daily colchicine can lower inflammation markers and joint pain in people with CPPD (pseudogout).

  Recruiting at 5 sites Phase 2 Brigham and Women's Hospital · Birmingham, Alabama and 4 other locations · NCT06855433

• Multicenter stress cardiac MRI measuring heart muscle blood flow

  This will test whether detailed stress cardiac MRI blood-flow measurements help identify heart-related causes of chest pain or shortness of breath in adults 35–85 with suspected coronary artery disease.

  Recruiting at 13 sites Brigham and Women's Hospital · San Francisco, California and 12 other locations · NCT06854458

• Early vedolizumab as first-line treatment for immune-related colitis

  We will test whether giving vedolizumab with a short steroid course helps adults with immune checkpoint inhibitor–related colitis recover by 8 weeks better than the usual steroid approach.

  Recruiting at 2 sites Phase 2 Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT06841705

• Enhanced local intensified radiation for older adults with glioblastoma

  This trial tests whether a higher-dose, short-course (hypofractionated) radiation schedule helps people aged 65 and older with newly diagnosed glioblastoma do better than the standard short-course radiation.

  Recruiting at 3 sites Phase 2 Brigham and Women's Hospital · Boston, Massachusetts and 2 other locations · NCT06835803

• Short course radiation treatment for retroperitoneal sarcoma before surgery

  This study is testing a shorter radiation treatment for patients with retroperitoneal sarcoma to see if it can be safely used before surgery.

  Recruiting Phase 1 Brigham and Women's Hospital · Boston, Massachusetts · NCT06812052

• Acceptance and Commitment Therapy to reduce disability in adults with chronic migraine

  This trial will test whether adding Acceptance and Commitment Therapy (ACT) to usual care helps adults with chronic migraine improve daily functioning and reduce headache frequency and pain.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06795867

• Informatics-assisted detection of immune-related side effects to improve biorepository enrollment

  This project tests whether an automated system that reads electronic health records can help identify cancer patients on immunotherapy who are having immune-related side effects so they can be enrolled in a biorepository.

  Recruiting at 2 sites Phase 1/2 Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT06789601

• Addressing the Double Burden of Malnutrition in Guatemala

  This trial tests a combined food support and lifestyle counseling program for pregnant and postpartum women and their infants in rural Guatemala to see if it reduces the in-house problem of maternal overweight/obesity and child stunting.

  Recruiting Brigham and Women's Hospital · Tecpán Guatemala, Departamento de Chimaltenango · NCT06750120

• Computer alert to help identify and manage familial high cholesterol

  This project will test whether a computer alert in the electronic health record helps clinicians recognize and treat adults with familial hypercholesterolemia.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06743659

• Osteoporosis Fracture Prevention (OPTIONS) program to support recovery after a broken hip or leg.

  This project tests whether a combined program of tailored exercise, healthy nutrition, and bone‑strengthening medicines with clinician decision support helps people 65+ who break a hip or leg recover in a skilled nursing facility and avoid future fractures.

  Recruiting at 2 sites Brigham and Women's Hospital · Baltimore, Maryland and 1 other locations · NCT06731608

• Tirzepatide to reduce alcohol cravings in adults with alcohol use disorder

  This 4-week randomized, double-blind study tests whether weekly tirzepatide injections reduce cue-triggered cravings in adults with alcohol use disorder.

  Recruiting Phase 2 Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT06727331

• Mobile app for mental health support for family caregivers in Thailand

  This study is testing a new mobile app designed to help family caregivers in Thailand take care of their mental health while they care for adults with chronic diseases.

  Recruiting Brigham and Women's Hospital · Bangkok · NCT06722287

• Semaglutide to support recovery from opioid use disorder

  This 12-week test tries weekly semaglutide injections in people with opioid use disorder who recently started buprenorphine to see if it reduces cue-reactivity and improves symptoms and safety measures.

  Recruiting Phase 2 Brigham and Women's Hospital · Boston, Massachusetts · NCT06639464

• Group visits combined with chiropractic care for older adults with chronic spine pain

  This trial will test whether combining chiropractic treatments with group medical visits helps adults 65 and older who have chronic neck, thoracic, or low back pain.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06632535

• SUSTAIN 2: Sustained HIV treatment support after interruptions in care

  This trial will test whether a six-month adherence club model with multi-month ART dispensing and peer support helps adults with HIV who missed care or have a raised viral load stay on treatment and reach viral suppression over 24 months.

  Recruiting Brigham and Women's Hospital · Cape Town · NCT06554223

• Cryotechnology for removing necrotic pancreatic tissue

  This study is testing a new freezing technique to see if it can help doctors remove dead tissue from the pancreas more effectively in patients with severe pancreatitis.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06553651

• Treatment of marginal ulcers using low-thermal argon plasma

  This study is testing if a new low-thermal argon plasma treatment can help heal stubborn ulcers that some people get after weight loss surgery, to see if it works better than the usual medicine.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06543316

• Using portable dynamic chest X-ray in the ICU

  This study is testing a new portable chest X-ray system in the ICU to see if it can give better pictures of lung movement and function compared to regular X-rays and CT scans for critically ill patients.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06538376

• Music and parental voice to support brain and language development in very preterm infants

  This project tests whether playing music alone or music with a parent's voice in the NICU can reduce stress and support brain and language development in very preterm infants.

  Recruiting Brigham and Women's Hospital · New Haven, Connecticut and 1 other locations · NCT06536296

• Eradicating H. Pylori with Argon Plasma During Endoscopy

  This study is testing a new argon plasma treatment during endoscopy to see if it can safely get rid of H. pylori infections in patients who haven't been treated yet.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06529159

• Nasal foralumab to reduce brain inflammation in early Alzheimer’s

  This trial will test whether nasal foralumab, given three times a week, can reduce brain immune inflammation and improve thinking in people aged 60–85 with mild cognitive impairment from early Alzheimer’s disease.

  Recruiting Phase 2 Brigham and Women's Hospital · Boston, Massachusetts · NCT06489548

• IV oxytocin to reduce pain after minimally invasive hysterectomy

  This trial will try an IV oxytocin infusion versus placebo to see if it lowers opioid use and pain in women having minimally invasive hysterectomy.

  Recruiting Phase 2 Brigham and Women's Hospital · Boston, Massachusetts · NCT06483659

• Understanding how psychological factors affect pain management in surgery

  This study looks at how feelings and worries about pain affect how well regional anesthesia works for people having surgery.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06466941

• Brain MRI markers after cardiac arrest to see if they predict good recovery

  This observational study tests whether advanced brain MRI measures can help predict who will recover brain function after a comatose cardiac arrest.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT06423768

• Novel therapeutics for acute ulcerative colitis

  This trial tests an oral (and sometimes IV) drug called BRS201 in adults with severe ulcerative colitis who have not improved with standard treatments.

  Recruiting Phase 2 Brigham and Women's Hospital · Chestnut Hill, Massachusetts and 1 other locations · NCT06420492

• BRS201 as a new oral treatment for mild ulcerative colitis

  This 12-week test checks whether taking the oral medication BRS201 can reduce inflammation and symptoms in adults with active mild ulcerative colitis.

  Recruiting Phase 2 Brigham and Women's Hospital · Chestnut Hill, Massachusetts · NCT06420375

• Using genetic data and MRI to identify significant prostate cancer

  This study is testing a new way to find significant prostate cancer in men by using genetic information and advanced MRI scans to see if it helps identify those at higher risk.

  Recruiting at 2 sites Brigham and Women's Hospital · Washington D.C., District of Columbia and 4 other locations · NCT06398639

• Exploring new brain stimulation targets for mental health conditions

  This study is testing how a brain stimulation treatment can help people with depression, anxiety, OCD, and schizophrenia by looking at changes in their brain and behavior.

  Recruiting Phase 2 Brigham and Women's Hospital · Sunnyvale, California and 1 other locations · NCT06376734

• Improving life for patients with chronic fatigue syndrome

  This study is testing if two medications can help people aged 18-65 with chronic fatigue syndrome feel better and manage their symptoms.

  Recruiting Phase 2 Brigham and Women's Hospital · Boston, Massachusetts · NCT06366724

• Positive psychology support for survivors of stem cell transplants

  This study is testing a new program that helps people who have had stem cell transplants feel happier and less anxious by encouraging them to do enjoyable activities.

  Recruiting at 3 sites Brigham and Women's Hospital · Tampa, Florida and 2 other locations · NCT06328127

• MRI guided prostate biopsy using a specialized needle holder frame

  This study is testing a new needle holder frame during MRI-guided prostate biopsies to see if it can help doctors take more accurate tissue samples from suspicious areas.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06302595

• Using computerized alerts to improve cholesterol treatment in patients with Peripheral Artery Disease

  This study is testing a new computer alert system to see if it can help doctors prescribe cholesterol-lowering medications more often for patients with Peripheral Artery Disease who aren't currently on them.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06300450

• Effect of Trazodone on Obstructive Sleep Apnea

  This study tests if taking trazodone before bed can help people with obstructive sleep apnea sleep better compared to a placebo.

  Recruiting Phase 1/2 Brigham and Women's Hospital · Boston, Massachusetts · NCT06286189

• Evaluating drug levels in children with HIV receiving TB prevention treatment

  This study is testing how well two medications work in children with HIV who are getting treatment to prevent tuberculosis, to see if they are safe and effective for different age groups.

  Recruiting Phase 1 Brigham and Women's Hospital · Ibadan, Oyo State · NCT06281834

• Maximizing lymph node removal from lung surgery specimens

  This project will try a standardized dissection method to remove more lymph nodes from lung cancer surgery specimens so staging is more accurate for people having lobectomy without prior treatment.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06252129

• Using AI to detect coronary artery calcium for better heart disease prevention

  This study tests if using an AI tool to spot calcium buildup in heart arteries can help doctors provide better preventive care for patients at risk of heart disease.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06235112

• Chiropractic care to reduce episodic migraine attacks.

  This pilot will test whether a 14-visit chiropractic care program, compared with headache health education plus usual care, can reduce migraine days and severity in adults with episodic migraine.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06229834

• Using a new endoscopy technique for bariatric patients

  This study is testing a new, less invasive endoscopy method for bariatric patients to see if it can improve safety and reduce costs when checking for stomach and digestive issues.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06200961

• Determining the effective dose of bupivacaine for labor pain relief

  This study is testing how much bupivacaine is needed to effectively relieve pain for women in labor after they receive a test dose of lidocaine.

  Recruiting Phase 4 Brigham and Women's Hospital · Boston, Massachusetts · NCT06146842

• Endoscopic sleeve gastroplasty for people with obesity and MASH

  This study will test whether endoscopic sleeve gastroplasty plus lifestyle changes helps adults with obesity and MASH lose weight and improve liver health compared with lifestyle changes alone.

  Recruiting at 2 sites Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT06138821

• Exploring how brain stimulation affects feelings of fullness in healthy people

  This study is testing how brain stimulation can change feelings of fullness in healthy people to better understand appetite control.

  Recruiting at 2 sites Brigham and Women's Hospital · Belmont, Massachusetts and 1 other locations · NCT06105164

• Using a new imaging test for prostate cancer before treatment

  This study is testing a new imaging scan to see how well it can show the spread of advanced prostate cancer before starting treatment.

  Recruiting at 2 sites Phase 4 Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT06099093

• Using metformin to reduce knee pain after ACL surgery

  This study is testing if metformin can help reduce knee pain and prevent arthritis in people recovering from ACL surgery.

  Recruiting at 9 sites Phase 2 Brigham and Women's Hospital · Atlanta, Georgia and 8 other locations · NCT06096259

• Embolization treatment for chronic shoulder pain

  This study is testing if adding a special procedure called embolization to physical therapy can help people with ongoing shoulder pain from rotator cuff issues feel better compared to just doing physical therapy alone.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06095050

• Investigating the effects of CO2 on obstructive sleep apnea

  This study is testing if giving CO2 during sleep can help people with obstructive sleep apnea breathe better and reduce their sleep apnea events.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06091098

• Using acetazolamide to improve obstructive sleep apnea

  This study is testing if a medication called acetazolamide can help people with obstructive sleep apnea breathe better during sleep.

  Recruiting Phase 1/2 Brigham and Women's Hospital · Boston, Massachusetts · NCT06091085

• Understanding how caveolin-1 deficiency affects weight loss with GLP-1 receptor agonists

  This study is trying to see how a lack of caveolin-1 affects weight loss in overweight and obese adults using a specific weight loss medication called GLP-1 receptor agonists.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06069622

• Detecting low PSMA prostate cancer using a special PET scan

  This study is testing a new type of PET scan to see if it can better detect advanced prostate cancer that has low PSMA levels or neuroendocrine features in patients.

  Recruiting at 2 sites Phase 1 Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT06062745

• App to support post-hospital care for people with multiple chronic conditions

  This trial will test a smartphone/tablet app to help people aged 55+ with heart failure, diabetes, or chronic kidney disease manage their care after leaving the hospital.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06051058

• Oxygen therapy for children with Down Syndrome and sleep apnea

  This study is testing whether giving extra oxygen during sleep can help improve thinking skills and overall health in children with Down Syndrome who have sleep apnea.

  Recruiting at 7 sites Phase 2 Brigham and Women's Hospital · Los Angeles, California and 6 other locations · NCT06043440

• Molecular Characterization of Pediatric Brain Tumors and Neuroblastoma

  This study is trying to understand how radiation treatment affects brain tumors and neuroblastoma in kids by collecting samples and data from patients to see how their tumors behave and respond to treatment.

  Recruiting at 2 sites Brigham and Women's Hospital · San Francisco, California and 1 other locations · NCT06000787

• Using brain stimulation to improve appetite control in Prader-Willi syndrome

  This study tests if a brain stimulation technique can help people with Prader-Willi syndrome control their appetite and feel full.

  Recruiting Brigham and Women's Hospital · Belmont, Massachusetts · NCT05938543

• Investigating the impact of food timing on diabetes risk

  This study is testing how the timing of meals affects metabolic health in healthy people to see if it can influence diabetes risk.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT05862818

• Understanding how physical activity affects heart and metabolic health

  This study is testing how our body's internal clock affects the benefits of exercise on heart health and metabolism to help create better workout guidelines.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT05838508

• Treatment for liver detoxification in patients with primary sclerosing cholangitis

  This study is testing a new oral medication called BRS201 to see if it can improve liver function and overall health in people with primary sclerosing cholangitis.

  Recruiting Phase 2 Brigham and Women's Hospital · Chestnut Hill, Massachusetts · NCT05835505

• Comparing lower and higher bicarbonate levels in dialysis patients

  This study tests if using lower or higher levels of bicarbonate during dialysis can affect heart rhythms and other symptoms in adult patients.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT05814146

• Dietary composition effects on appetite and energy regulation

  This study is testing how different types of diets affect hunger and energy use to help people manage obesity better.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT05800990

• Personalized exercise program for patients with transthyretin cardiac amyloidosis

  This study is testing a personalized exercise program to see if it can help people with transthyretin cardiac amyloidosis feel stronger and improve their quality of life.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT05797857

• NAD supplementation for improving kidney health in diabetes

  This study is testing if taking a supplement called NMN can help improve kidney health in older adults with type 2 diabetes by lowering a specific marker in their urine.

  Recruiting Phase 2 Brigham and Women's Hospital · Boston, Massachusetts · NCT05759468

• Evaluating behavioral treatments for insomnia in disadvantaged adults

  This study is testing whether a shorter online treatment for insomnia works just as well as a more traditional therapy for people with low income who have trouble sleeping.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT05759065

• Aim to prevent diagnostic errors through hospital collaboration and teamwork

  Hospitals will share data to see how often diagnostic errors happen and test ways to work together to reduce them for hospitalized patients.

  Recruiting at 2 sites Brigham and Women's Hospital · San Francisco, California and 1 other locations · NCT05747755

• Using magnesium to prevent kidney injury in mesothelioma patients during surgery

  This study is testing if giving high doses of magnesium during surgery can help prevent kidney injury in patients with mesothelioma who are receiving chemotherapy.

  Recruiting Phase 2 Brigham and Women's Hospital · Boston, Massachusetts · NCT05730816

• Using endoscopic ultrasound to assess liver stiffness in patients with fatty liver disease

  This study is testing if a special ultrasound can help find liver damage in people with fatty liver disease who are overweight, comparing it to other methods to see which works best.

  Recruiting at 2 sites Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT05728697

• Preparing patients for bladder cancer surgery

  This study tests a program that helps bladder cancer patients get stronger and healthier before their surgery to see if it improves their recovery.

  Recruiting at 2 sites Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT05715684

• Endoscopic Antral Myotomy for Weight Loss

  This study is testing a new weight loss procedure called Pylorus Sparing Antral Myotomy to see if it helps people with obesity lose weight safely and effectively on its own.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT05711758

• Testing a microdevice for drug delivery in kidney cancer

  This study is testing a tiny device that delivers small amounts of cancer drugs directly to kidney tumors to see if it helps people with advanced kidney cancer.

  Recruiting Phase 1 Brigham and Women's Hospital · Boston, Massachusetts · NCT05700461

• Effects of a mineralocorticoid receptor antagonist on heart function in hypertensive patients

  This study is testing if a heart medication called eplerenone can improve heart function better than another medication in people with high blood pressure and thickened heart muscles.

  Recruiting Phase 4 Brigham and Women's Hospital · Boston, Massachusetts · NCT05593055

• Implantable microdevice drug screening for salivary and head and neck cancers

  This will test whether a tiny implantable microdevice can safely and quickly deliver and screen multiple cancer drugs inside salivary gland and other head and neck tumors in patients scheduled for surgical removal.

  Recruiting at 2 sites Early Phase 1 Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT05553782

• Dose of bupivacaine needed for pain relief in labor with lidocaine test dose

  This trial tests the amount of bupivacaine needed to give initial comfortable pain relief for laboring women who receive a lidocaine test dose before an epidural.

  Recruiting Phase 4 Brigham and Women's Hospital · Boston, Massachusetts · NCT05543694

• Preventing cardiovascular and kidney disease in patients with type 2 diabetes

  This study is testing which of two diabetes treatments can better prevent heart and kidney problems in people with type 2 diabetes who are at high risk for cardiovascular disease.

  Recruiting at 36 sites Phase 4 Brigham and Women's Hospital · Huntsville, Alabama and 35 other locations · NCT05390892

• Effects of melatonin on uterine contractions in pregnant women

  This study tests whether taking melatonin can change the frequency of uterine contractions in full-term pregnant women.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT05358834

• Atomoxetine and DAW2020 for treating obstructive sleep apnea

  This study is testing if a combination of two medications can help people with obstructive sleep apnea breathe better while they sleep.

  Recruiting Phase 1/2 Brigham and Women's Hospital · Boston, Massachusetts · NCT05350215

• Drug treatment for patients with obstructive sleep apnea who didn't respond to other therapies

  This study is testing if adding certain medications can help people with obstructive sleep apnea who haven't improved with other treatments feel better.

  Recruiting Phase 1/2 Brigham and Women's Hospital · Boston, Massachusetts · NCT05293600

• Evaluating the effects of PCSK-9 inhibition on blood flow in patients with stable coronary disease

  This study is testing if a new medication can improve blood flow in people with stable coronary artery disease over a year.

  Recruiting Phase 4 Brigham and Women's Hospital · Boston, Massachusetts · NCT05152888

• Using advanced navigation systems for lymph node surgery in urologic cancer

  This study is testing if using advanced navigation systems during lymph node surgery can help improve outcomes for patients with urologic cancer.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT05132283

• Evaluating dolutegravir in children with HIV and TB receiving different doses of rifampicin

  This study is testing how safe and effective a medication called dolutegravir is for young children with both HIV and TB who are taking different doses of another medicine called rifampicin.

  Recruiting Phase 1 Brigham and Women's Hospital · Ibadan, Oyo State · NCT05069688

• Impact of Aldosterone Blockade on Heart Function in Primary Aldosteronism

  This study is testing if a medication that blocks a hormone called aldosterone can improve heart function in people with primary aldosteronism, which causes high blood pressure.

  Recruiting Phase 4 Brigham and Women's Hospital · Boston, Massachusetts · NCT05030545

• Using nanoparticles to enhance radiation treatment for brain metastases

  This study is testing if adding special nanoparticles to radiation therapy can help people with brain metastases get better results than radiation alone.

  Recruiting at 2 sites Phase 2 Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT04899908

• Understanding Atrial Fibrillation in Cardiac Surgery Patients

  This study looks at how common atrial fibrillation is in patients having heart surgery by using a wearable heart monitor to see how it affects their recovery and hospital stays.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT04880265

• Dietary intervention to improve health for night shift workers

  This study is testing if a special diet can help night shift workers improve their health and manage the challenges that come with working at odd hours.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT04868526

• Testosterone treatment for pain relief in men with opioid-induced low testosterone

  This study is testing if testosterone treatment can help men with chronic spinal pain and low testosterone from using opioids feel better and improve their quality of life.

  Recruiting Phase 2 Brigham and Women's Hospital · Boston, Massachusetts · NCT04798469

• Detecting small fiber neuropathy through skin analysis

  This study is testing a new way to diagnose small fiber neuropathy by looking at skin images to see if it can help find the condition earlier and make it easier for patients.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT04759443

• Using a microdevice to measure tumor response in ovarian and related cancers

  This study is testing a tiny device that will be placed in tumors of patients with advanced ovarian and related cancers to see how well different chemotherapy drugs work before surgery.

  Recruiting at 2 sites Phase 1 Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT04701645

• Ultrasound therapy for cardiac amyloidosis

  This study is testing whether ultrasound therapy can improve heart blood flow and function in people with cardiac amyloidosis.

  Recruiting Phase 4 Brigham and Women's Hospital · Boston, Massachusetts · NCT04667494

• Using defibrotide to treat severe COVID-19 pneumonia

  This study is testing if the drug defibrotide can safely help hospitalized patients with severe COVID-19 pneumonia who need oxygen support.

  Recruiting Phase 2 Brigham and Women's Hospital · Boston, Massachusetts · NCT04652115

• Imaging brain synapse density in people with multiple sclerosis

  This study will test whether a new PET tracer ([F-18]SDM-8) can measure synaptic (brain connection) loss in people with progressive and relapsing MS compared with healthy volunteers.

  Recruiting Early Phase 1 Brigham and Women's Hospital · Boston, Massachusetts · NCT04634994

• Using MRI to improve radiation therapy planning for cancer treatment

  This study is testing whether using MRI scans can help doctors plan better radiation treatments for people with different types of cancer, like prostate and liver cancer.

  Recruiting at 2 sites Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT04545957

• Using colchicine to treat heart issues in chronic kidney disease patients

  This study is testing if colchicine can help reduce heart inflammation in people aged 21 to 80 with chronic kidney disease.

  Recruiting Phase 2 Brigham and Women's Hospital · Boston, Massachusetts · NCT04500665

• Using MRI-guided radiation therapy for treating certain cancers

  This study is testing if using MRI to guide radiation therapy along with chemotherapy can safely and effectively treat patients with gastric and breast cancers.

  Recruiting at 2 sites Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT04368702

• Implantable microdevice to test drug effects in primary brain tumors

  A tiny implantable device is placed into your glioma during surgery to see if local releases of standard glioma drugs cause tumor responses.

  Recruiting Early Phase 1 Brigham and Women's Hospital · Boston, Massachusetts · NCT04135807

• Innovative surgery for improving lower limb prosthetics and reducing pain in amputees

  This study is testing a new type of surgery for amputees to see if it can help reduce pain and improve movement by using special devices in their residual limb.

  Recruiting at 2 sites Brigham and Women's Hospital · Bethesda, Maryland and 2 other locations · NCT04063592

• Using MRI to distinguish between tumor recurrence and radiation effects in brain metastases

  This study is testing if new MRI techniques can help tell the difference between a returning brain tumor and changes caused by radiation in patients with brain metastases.

  Recruiting at 2 sites Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT04033497

• Deceased-donor uterine transplant for women with uterine-factor infertility

  We will try a uterus transplant from a deceased donor to help women with uterine-factor infertility who can produce embryos and meet health and psychosocial requirements.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT04026893

• A new method for upper limb amputation to improve control and sensation

  This study is testing a new way to perform upper limb amputations to see if it can help patients control advanced prosthetics better and feel more sensation in their limbs.

  Recruiting at 4 sites Brigham and Women's Hospital · Bethesda, Maryland and 3 other locations · NCT03882073

• Using focused ultrasound to treat drug-resistant epilepsy

  This study is testing a new ultrasound treatment for people with drug-resistant epilepsy to see if it can help reduce their seizures without using medication.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT03868293

• Testing new medications for obstructive sleep apnea

  This study is testing four new medications to see if they can help people with obstructive sleep apnea breathe better during sleep.

  Recruiting Phase 1/2 Brigham and Women's Hospital · Boston, Massachusetts · NCT03858751

• Computerized alerts to prevent blood clots in hospitalized patients

  This study is testing if using computer alerts can help doctors give blood clot prevention medication to hospitalized patients who are at risk.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT03728166

• Image-guided VATS versus standard VATS to remove small lung nodules.

  We will test image-guided VATS and standard VATS to see how they perform for adults with small peripheral lung nodules (≤2 cm).

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT03623958

• Hospital-level care delivered at home for acutely ill adults

  This trial tries to deliver hospital-level care at home to adults with sudden illnesses like infections, heart failure, COPD, asthma, or gout flares to see if it's as safe, improves patient experience, and lowers costs.

  Recruiting at 2 sites Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT03524222

• Exploring brain connectivity in patients with depression

  This study is testing if a special brain treatment called TMS can improve brain function and help people with depression who haven't found relief from medication.

  Recruiting at 2 sites Brigham and Women's Hospital · Boston, Massachusetts and 3 other locations · NCT03276793

• Comparing Alvimopan to placebo for bowel recovery after bladder cancer surgery

  This study is testing if a medication called Alvimopan can help people recover their bowel function faster after bladder cancer surgery compared to a placebo.

  Recruiting Phase 3 Brigham and Women's Hospital · Boston, Massachusetts · NCT03216525

• C-11 MRB PET imaging of the brain's norepinephrine system in people with MS

  This project will try C-11 MRB PET scans to see if the brain's norepinephrine transporter is lower in adults with multiple sclerosis than in similar healthy adults.

  Recruiting Phase 1/2 Brigham and Women's Hospital · Boston, Massachusetts · NCT03207464

Showing recruiting studies first, then the newest. Describe your situation to find the ones that fit you.

NIH-funded research (newest 40 of 1351)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Targeted therapies for glioblastoma in adults and kids

  A large NIH program is exploring new brain cancer therapies, including drugs that reach the brain and work against glioblastoma in both children and adults.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11608562

• Statins to Prevent Cancer-Associated Blood Clots in Cancer Patients

  A large study will test whether taking rosuvastatin every day for a year can lower the chance of dangerous blood clots in people with cancer, without raising the risk of bleeding.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11606487

• Preterm infant body composition and early-life health after NICU stay

  This grant studies how body composition in very preterm babies relates to later brain development and risk of obesity or diabetes, with findings meant to improve care from NICU through early childhood.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11600939

• Rapid Emergency Skills for Prehospital Optimization and Delivery (RESPOND) for Guatemala

  A lightweight, AI-enabled prehospital training and triage program helps volunteer firefighters in Guatemala deliver faster, better care to trauma patients.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11599796

• Rapid Emergency Skills for Prehospital Optimization and Notification in Guatemala

  A mobile, AI-powered training and triage program helps volunteer emergency responders in Guatemala provide faster, safer trauma care and notify hospitals more quickly.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11599795

• Understanding antibiotic allergy to improve care for patients

  Scientists are testing new ideas to understand why some people develop severe allergic reactions to antibiotics and how to prevent or treat them.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11593203

• Mobile app to help family caregivers in Thailand manage distress

  A mobile app called CAMMA would help family members caring for adults with chronic illnesses in Thailand feel less depressed and anxious through a culturally tailored mental health support program.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11580924

• Shorter, rifamycin-free TB treatment using BCZD for drug-susceptible TB

  A 12-week, AI-informed drug combination (bedaquiline, clofazimine, pyrazinamide, and delamanid) is being tested against the standard 26-week therapy for adults with drug-susceptible TB to see if it can cure faster with fewer side effects.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11563787

• Shorter TB treatment using four drugs for drug-susceptible TB

  A 12-week, AI-informed drug regimen (bedaquiline, clofazimine, pyrazinamide, delamanid) is being tested against standard therapy for drug-susceptible TB to see if it works faster and safely across adults in Haiti and South Africa.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11563786

• Ethical, multimodal AI for predicting preeclampsia risk in early pregnancy

  A data-driven AI tool uses early-pregnancy information from medical records, ultrasound, and notes to predict preeclampsia risk and support safer pregnancy care.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11556765

• Understanding blocks to HIV-1 RNA maturation in CD4+ T cells

  Researchers are studying why HIV stays hidden in certain immune cells and how to encourage the virus to express and be cleared, even when people are on effective therapy.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11553297

• Understanding how bones communicate to stay strong in a rare bone disease

  Researchers are studying how bone-resorbing cells and bone-forming cells talk to each other in a rare condition called autosomal dominant osteopetrosis type II to find new ways to keep bones healthy.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11548351

• Botswana CASCADE Clinical Trials Site focuses on cervical cancer prevention for people living with HIV

  A national HIV-focused cancer program is testing better ways to screen for cervical precancers and treat them early so people living with HIV have fewer cancer deaths.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11535389

• CT-DPACC for AMP SCZ: Coordinating Big Data to Understand and Prevent Schizophrenia

  A nationwide effort will process and analyze data from a large schizophrenia study to help scientists find patterns that could prevent psychosis in young people at risk.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11533656

• PREDICT: Data and AI tools to study psychosis risk in youth

  A national effort uses big data and smart computer tools to find new clues that predict psychosis risk in children and teens who show early signs.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11527266

• Paternal exposures and sperm epigenetics linked to autism in children

  This project looks at how a father's environment and health before conception might influence autism risk in his children.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11520495

• PREDICT: Data-driven tools to understand and coordinate early psychosis risk in youth

  Aciient-style data platform and analysis center will combine big datasets and AI methods to improve how we predict and study early signs of psychosis in children and adolescents.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11519474

• Designing T-cell receptors to better target cancer

  Using AI plus large-scale lab data to learn how immune T cells recognize tumor markers so future therapies can target cancer more precisely.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11514454

• eMERGE Phase IV: Using electronic health records and DNA data to study genomic risk and return of results

  A national program is testing how genomic risk results shared through health records affect care decisions for both adults and children.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11514430

• Predicting how genetic variants affect human disease

  A research project aims to understand how genetic differences influence disease by mapping how non-coding variants and genes control cell behavior.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11513893

• 3D human blood-vessel model to understand blood clots and test treatments

  Researchers are building a 3D human blood-vessel model with live imaging to speed testing of clot-preventing and clot-breaking treatments for people at risk of deep vein thrombosis and pulmonary embolism.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11504755

• Iodized salt and early brain development in babies of pregnant and breastfeeding women in rural Ethiopia

  This grant tests whether giving iodized salt to pregnant and breastfeeding women helps their babies’ brain development.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11474405

• Safer HIV and TB treatment and prevention for young children

  This project looks at how the HIV medicine dolutegravir interacts with TB drugs in young children so doctors can find safe, effective doses for treatment and prevention.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11470882

• Why cancer deaths are higher in rural communities

  This project looks at cancer death rates and local social, economic, and health-care factors to understand why people with cancer in rural areas often have worse outcomes than those in cities.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11469037

• Integrated nutrition support for mothers and young children in Guatemala

  This project offers food supplements and counseling to pregnant and new mothers and their young children in rural Guatemala to reduce both maternal overweight and child undernutrition.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11466687

• Precision Alzheimer's Therapies: Predicting Who Benefits and Safeguards

  A new program at Brigham and Women’s Hospital aims to find blood and genetic markers that predict who will benefit most from anti-amyloid medications for Alzheimer's disease and who might have side effects.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11465221

• Sleep spindles as markers for aging, Alzheimer's, and Down syndrome

  Aging, Alzheimer's disease, and Down syndrome may each change how sleep spindles behave, and this study aims to map those patterns to help identify biomarkers.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11463474

• Understanding how kidney immune cells talk to each other to prevent transplant rejection

  A study to understand how certain immune cells in kidney transplants interact and how this affects rejection, with aims to find new ways to protect transplanted kidneys.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11460602

• What makes CPPD and osteoarthritis worsen in older adults and how colchicine might help

  Researchers will study how inflammation and biomarkers relate to knee pain in adults with CPPD and osteoarthritis to see if daily colchicine helps.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11459691

• Brain imaging of biological markers in schizophrenia

  This project looks for brain-scan and blood-test signs linked to schizophrenia, especially early changes in extracellular brain water and inflammation, for people with or at risk for the illness.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11458413

• Understanding how nerves influence cancer growth from brain to the rest of the body

  This NIH grant explores how neural signals affect cancer growth, including brain tumors and cancers in other parts of the body, with the goal of uncovering new ways to treat cancer.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11457483

• Diet, chronic inflammation, and aggressive breast cancer

  This project looks at whether long-term inflammation linked to diet is connected to higher risk of aggressive breast cancers in women using blood samples and molecular data.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11457143

• TruFERT: a new AI-enabled tool to tailor endometrial readiness in frozen embryo transfer

  A patient-friendly platform using AI and hormone data to better time frozen embryo transfers and improve chances of implantation.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11455938

• AHR-driven immunosuppression in glioblastoma and new therapeutic targets

  A personalized cancer study aims to understand why glioblastoma suppresses the immune system and to find ways to boost anti-tumor immunity in patients with this brain tumor.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11455312

• Palmitoyltransferase and GBA1 function restoration in Parkinson’s and Lewy body dementia

  A fast-moving study looks at whether tweaking a fat-attachment process on proteins can restore healthy enzyme function and slow the progression of Parkinson’s disease and Lewy body dementia.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11453161

• Bioengineered extracellular vesicles to help people with inherited metabolic diseases like Gaucher

  A researcher at Brigham and Women’s Hospital is developing a new cell-sized delivery system to bring enzyme therapy directly to where it’s needed in patients with Gaucher disease and related conditions.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11452248

• Integrating molecular signals to guide thyroid cancer care

  A doctor-scientist team at Brigham and Women’s Hospital is studying how tumor biology and the immune environment can guide personalized monitoring and treatment for differentiated thyroid cancer.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11452026

• Metabolic gut-macteria pathways after bariatric surgery

  This grant explores how bariatric surgery changes gut microbes and their chemicals to improve glucose control in adults with type 2 diabetes.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11449773

• Role of Energy Metabolism in Body Segmentation (developmental biology)

  This grant explores how cellular metabolism shapes the way the spine and muscles form during embryonic development, with potential implications for understanding congenital body patterning in humans.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11449570

• Understanding how the Epstein-Barr virus toggles on and off in cancer cells

  This project studies how EBV decides to become active in cancer cells and how this could lead to new treatments for EBV-related cancers in people with AIDS.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11448550

Quick answers

How many clinical trials run by Brigham and Women's Hospital are recruiting right now?

156, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in United States (151 trials), Nigeria (2 trials), South Africa (1 trial), Thailand (1 trial), Guatemala (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 26, Phase 4: 13, Phase 1/2: 10, Phase 1: 8. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →