Detecting small fiber neuropathy through skin analysis
Detection of Small Fiber Neuropathy Using Skin Properties
This study is testing a new way to diagnose small fiber neuropathy by looking at skin images to see if it can help find the condition earlier and make it easier for patients.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 400 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Brigham and Women's Hospital Academic / other |
| Locations | 1 site (Boston, Massachusetts) |
| Trial ID | NCT04759443 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on improving the diagnosis of small fiber neuropathy, a condition that causes debilitating symptoms like burning pain and dysautonomia. It employs advanced image processing techniques to analyze skin pictures, extracting statistical features that indicate the loss of small nerve fibers. By verifying the accuracy of these findings against skin biopsies, the study aims to make diagnosis more accessible and less invasive than traditional methods. The goal is to enhance early detection and treatment options for patients suffering from this condition.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who have undergone autonomic testing and skin biopsies.
Not a fit: Patients with significant hair on their legs, dermatological disorders affecting skin composition, or those using skin lotions may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could provide a less invasive and more widely available method for diagnosing small fiber neuropathy.
How similar studies have performed: While similar diagnostic approaches have been explored, this specific method utilizing image processing for small fiber neuropathy detection is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with age 18 year or older * Patients that sign the informed consent form to participate in this study * Patients completed the autonomic testing with skin biopsies Exclusion Criteria: * Patients with significant hairs at the legs that will cover the skin * Any dermatological disorder that can affect the skin composition * The use of skin lotion
Where this trial is running
Boston, Massachusetts
- Brigham and Women's Faulkner Hospital — Boston, Massachusetts, United States (Recruiting)
Study contacts
- Study coordinator: Peter Novak, MD
- Email: pnovak2@bwh.harvard.edu
- Phone: 617-732-7432
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.