Detecting small fiber neuropathy through skin analysis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on improving the diagnosis of small fiber neuropathy, a condition that causes debilitating symptoms like burning pain and dysautonomia. It employs advanced image processing techniques to analyze skin pictures, extracting statistical features that indicate the loss of small nerve fibers. By verifying the accuracy of these findings against skin biopsies, the study aims to make diagnosis more accessible and less invasive than traditional methods. The goal is to enhance early detection and treatment options for patients suffering from this condition.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with age 18 year or older
* Patients that sign the informed consent form to participate in this study
* Patients completed the autonomic testing with skin biopsies

Exclusion Criteria:

* Patients with significant hairs at the legs that will cover the skin
* Any dermatological disorder that can affect the skin composition
* The use of skin lotion

Where it's running

• Brigham and Women's Faulkner Hospital
  Boston, Massachusetts, United States Recruiting

Study contacts

• Study coordinator: Peter Novak, MD
• Email: pnovak2@bwh.harvard.edu
• Phone: 617-732-7432

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• See if small fiber neuropathy is common in people with primary Sjögren’s syndrome

  This study tests whether small fiber neuropathy is common in adults with primary Sjögren’s syndrome using a quick, non-invasive Sudoscan test.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT07917442

• Magnetic Brain Stimulation for Pain in Small Fiber Neuropathy

  This study tests whether repetitive transcranial magnetic stimulation (rTMS) can lessen pain in adults with idiopathic small fiber neuropathy.

  Recruiting Maastricht University Medical Center · Maastricht, Limburg · NCT07805057

• Observing autonomic neuropathies and Ehlers Danlos syndromes over time

  This study is trying to understand how autonomic neuropathies and Ehlers Danlos syndromes change over time in patients compared to healthy individuals.

  Recruiting RWTH Aachen University · Aachen, North Rhine-Westphalia · NCT04310644

• IVIG (Panzyga) treatment for autoimmune small fiber neuropathy with TS-HDS, FGFR3, or Plexin D1 antibodies

  This trial will try IVIG (Panzyga) to see if it reduces pain and increases nerve fiber density in adults with antibody-positive autoimmune small fiber neuropathy.

  Recruiting Phase 2 Endeavor Health · Glenview, Illinois · NCT04153422

• Impact of Sjögren's syndrome on quality of life and costs

  This study is trying to see how small fiber neuropathy affects the quality of life and costs for people with Sjögren's syndrome.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT03509064

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.