Comparing lower and higher bicarbonate levels in dialysis patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effects of different concentrations of dialysate bicarbonate on cardiac rhythms and other symptoms in adult patients undergoing hemodialysis. Participants will be randomly assigned to receive either a lower concentration (30 mEq/L) or a higher concentration (35 mEq/L) of bicarbonate during their dialysis sessions in the hospital. The study aims to determine how these varying levels impact QTc prolongation, premature ventricular contractions, and overall patient safety during dialysis. Patients will be monitored for up to six dialysis sessions or until discharge.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* prevalent end-stage renal disease, on maintenance HD \> 90 days
* age ≥ 18 years old
* thrice weekly HD

Exclusion Criteria:

* hemoglobin \< 8.0 g/dL
* pregnancy
* any physical, mental or medical condition which limited the ability to provide written informed consent

Where it's running

• Brigham and Women's Hospital
  Boston, Massachusetts, United States Recruiting

Study contacts

• Principal investigator: Katherine S Ravi, MD, MPH — Brigham and Women's Hospital
• Study coordinator: Katherine S Ravi, MD, MPH
• Email: ksravi@bwh.harvard.edu
• Phone: (617) 732-6383

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.