Coronary calcium and high-sensitivity troponin testing in people with rheumatoid arthritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational, single-center study enrolls adults aged 40–79 with rheumatologist-diagnosed rheumatoid arthritis and at least one ASCVD risk factor but without diabetes or current statin therapy. Participants will have blood tests for high-sensitivity cardiac troponin and undergo coronary artery calcium scoring to see whether these markers identify higher cardiovascular risk than standard population risk calculators. Individuals on statins, on other lipid-lowering drugs, with diabetes, or who are pregnant are excluded. The aim is to determine whether these biomarkers can guide earlier initiation of lipid-lowering therapy in RA patients who would otherwise be missed.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* RA diagnosed by a rheumatologist
* Age 40- 79
* ≥1 ASCVD risk factor including prediabetes, hypertension, BMI \>30, current or history of cigarette smoking

Exclusion Criteria:

* Patients on a statin or with a contraindication to statin, on a cholesterol absorption inhibitor, or on a PCSK9 inhibitor
* Patients with diabetes mellitus
* Pregnancy

Where it's running

• Massachusetts General Hospital: Rheumatology
  Boston, Massachusetts, United States Recruiting
• Brigham and Womens Hospital
  Boston, Massachusetts, United States Recruiting
• Brigham and Women's Faulkner Hospital
  Boston, Massachusetts, United States Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.