Clinical trial Recruiting at 2 sites Interventional Ages 65 and up

Osteoporosis Fracture Prevention (OPTIONS) program to support recovery after a broken hip or leg.

Official title: Effectiveness of an Multi-Modal Intervention for Transitions of Care After Lower Limb Fracture

Run by Brigham and Women's Hospital · NCT06731608 · Data updated 2026-11-12

This project tests whether a combined program of tailored exercise, healthy nutrition, and bone‑strengthening medicines with clinician decision support helps people 65+ who break a hip or leg recover in a skilled nursing facility and avoid future fractures.

More Osteoporosis trials

Quick facts

Study typeInterventional
Ages65 Years and up
SexAll
Enrollment1344 (estimated)
SponsorBrigham and Women's Hospital
Academic / other
Locations2 sites (Baltimore, Maryland and 1 other locations)
StatusRecruiting
StartedJanuary 16, 2026
Main results expectedAugust 1, 2028
Study endsFebruary 1, 2029
Registry record updatedJanuary 29, 2026
Trial IDNCT06731608 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are community‑dwelling adults aged 65 or older who are admitted to a participating SNF for rehabilitation after a lower‑limb fragility fracture and are expected to discharge back to the community, are English or Spanish speakers, and have adequate cognition to participate (BIMS score >7).

Probably not a fit

Patients receiving hospice or end‑of‑life care, those with serious cognitive impairment (BIMS 0–7), non‑English/non‑Spanish speakers, or those with SNF stays under seven days or not expected to return to the community are unlikely to benefit from this program.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Investigators will introduce OPTIONS, an integrated multi‑modal intervention that uses clinical decision support for clinicians and tailored education for patients and care partners to increase use of exercise, nutrition, and osteoporosis medications during and after skilled nursing facility (SNF) rehabilitation. The program targets older adults who were living in the community before a lower‑limb fragility fracture and who are admitted to participating SNFs for rehabilitation with an expected discharge back to the community. Implementation will be done in partnership with health‑IT systems (including PointClickCare) to deliver decision support and coordinate care across the SNF and transition home. Outcomes include uptake and sustained use of evidence‑based interventions and improved recovery and fracture prevention across the care transition.

Why it matters

Potential benefit: If successful, the program could increase use of proven therapies after a hip or leg fracture, reduce future fractures, and improve recovery and independence for older adults.

How similar studies have gone: Components such as exercise, nutrition, and osteoporosis medications have shown benefit in prior studies, but embedding them via clinical decision support across SNFs and transitions is a relatively novel approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age ≥65 years old
* Community-dwelling at the time of fracture
* Admission to a participating SNF for rehabilitation following a lower limb fragility fracture, including pelvic fractures
* Expected discharge to the community (home or assisted living)

Exclusion Criteria:

* Not English or Spanish speaker
* Admission Brief Interview for Mental Status (BIMS) score 0-7
* SNF length of stay \< 7 days
* Regular access to a working telephone or other communication device
* Receiving hospice or end-of-life care

Where it's running

  • University of Maryland, Baltimore, Department of Epidemiology and Public Health, Division of Gerontology
    Baltimore, Maryland, United States
    Recruiting
  • Brigham and Women's Hospital
    Boston, Massachusetts, United States
    Recruiting

Study contacts

  • Principal investigator: Denise Orwig, PhD — University of Maryland, Baltimore
  • Study coordinator: Patricia Dykes, RN, PhD
  • Email: pdykes@bwh.harvard.edu
  • Phone: 617-850-5748

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.