Clinical trial Recruiting at 1 site Interventional Ages 18 to 45

Dietary intervention to improve health for night shift workers

Official title: Dietary Intervention to Mitigate Adverse Consequences of Night Work

Run by Brigham and Women's Hospital · NCT04868526 · Data updated 2026-11-12

This study is testing if a special diet can help night shift workers improve their health and manage the challenges that come with working at odd hours.

Quick facts

Study typeInterventional
Ages18 Years to 45 Years
SexAll
Enrollment24 (estimated)
SponsorBrigham and Women's Hospital
Academic / other
Locations1 site (Boston, Massachusetts)
StatusRecruiting
StartedMarch 29, 2023
Main results expectedSeptember 1, 2026
Study endsSeptember 1, 2026
Registry record updatedDecember 5, 2025
Trial IDNCT04868526 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are healthy adults aged 18-45 with a BMI between 20.0 and 29.9 of European, Hispanic, or African-American ancestry.

Probably not a fit

Patients with acute or chronic medical conditions, or those with a history of substance dependency or psychiatric disorders, may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effectiveness of a dietary intervention designed to mitigate the negative health impacts associated with night shift work. Participants will undergo two inpatient stays where they will receive identical meals while their metabolic responses are closely monitored through frequent blood draws and various biological sample collections. The study focuses on addressing the metabolic health challenges faced by shift workers due to circadian misalignment, with the goal of developing evidence-based dietary strategies to improve their health outcomes.

Why it matters

Potential benefit: If successful, this intervention could significantly improve metabolic health and reduce the risk of diabetes among night shift workers.

How similar studies have gone: While the specific dietary intervention for night shift workers is novel, similar studies addressing metabolic health in shift workers have shown promising results.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* 18-45 yr old
* BMI 20.0-29.9
* European/Hispanic/African-American ancestry
* No acute, chronic or debilitating medical conditions (e.g. metabolic, cardiovascular, respiratory, neurological, cancers, etc.)

Exclusion Criteria:

* Currently smoking/vaping or 5 or more years of smoking/vaping
* History of drug or alcohol dependency
* History of psychiatric illness or disorder

Where it's running

  • Brigham and Women's Hospital
    Boston, Massachusetts, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.