Statins to Prevent Cancer-Associated Blood Clots in Cancer Patients

Who could benefit from this research

What this research studies

If you have cancer and are at higher risk for blood clots, this trial will see if rosuvastatin can safely reduce clotting events over 12 months. Participants will be randomly assigned to rosuvastatin or placebo, alongside standard cancer care, with careful monitoring for bleeding and other side effects. The study uses a novel pre-screening tool to efficiently identify eligible patients across multiple centers and will enroll up to 4,000 participants. Results could inform new approaches to prevent clots in cancer patients who are not already on anticoagulants. The trial builds on prior data suggesting statins may lower clot risk through anti-inflammatory and other lipid-independent mechanisms.

Why it matters

Where this research is happening

• Brigham and Women's Hospital
  Boston, United States Active

Researchers

• Principal investigator: Ridker, Paul M. — Brigham and Women's Hospital
• Study coordinator: Ridker, Paul M.

Related research

Other NIH-funded projects on the same topics.

• Optimal use of blood thinners for venous clots in people with cirrhosis

  This grant hopes to figure out the safest and most effective way to use oral anticoagulants for adults with cirrhosis who develop venous clots.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11427117

• PET/CT imaging to detect chemotherapy-related vascular harm in young cancer patients

  A non-invasive PET/CT scan method using standard care imaging is being tested to identify which pediatric and young adult cancer patients are at higher risk of blood clots from chemotherapy.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11396394

• Statins to Prevent Cancer-Associated Blood Clots in Cancer Patients

  A large clinical trial will test whether taking rosuvastatin daily for a year helps prevent dangerous blood clots in people with newly diagnosed or relapsed cancer who aren’t already getting anticoagulants.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11387857

• BCOR's role in blood clot risk and liver genetics

  A Johns Hopkins-led study is exploring how a human gene, BCOR, may control liver-produced clotting factors to influence venous blood clots.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11378452

• Personalized risk-prediction for hospital-acquired blood clots in adults

  A real-time risk model helps doctors identify adults in the hospital who are at higher risk of developing blood clots so they can prevent them safely.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11373022

• Genomic and Proteomic Markers for Recurrent Venous Thromboembolism

  Researchers are studying genetic and protein clues to predict who will have another blood clot after an initial VTE event, so doctors can tailor safer, more effective care.

  NIH research University of Washington · Seattle, United States · NIH-11364727

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.