Understanding antibiotic allergy to improve care for patients
Official title: Harnessing translational research to advance understanding and clinical care in antibiotic allergy
Funded at Brigham and Women's Hospital · NIH-11593203 · Data updated 2026-11-12
Scientists are testing new ideas to understand why some people develop severe allergic reactions to antibiotics and how to prevent or treat them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 24, 2025 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $149,657 |
| NIH project number | 3UG3AI190114-02S1 |
| Project ID | NIH-11593203 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with suspected or confirmed antibiotic-induced delayed-type hypersensitivity or related severe skin/ systemic reactions.
✕Less likely to help
Patients without antibiotic allergies or without involvement of the proposed factors may see little direct benefit.
What this research studies
This grant explores why antibiotic-induced delayed-type drug hypersensitivity happens, looking beyond the usual immune players. Researchers will study 3 possible factors—how regulatory T cells behave, whether an infection is active at the same time, and the patient’s microbiome—to see which ones drive the reactions or affect severity. The work uses samples from people and mouse models to test these ideas in a translational way that could inform better diagnosis and treatment. If successful, findings could shift how clinicians approach antibiotic allergies in everyday care.
Why it matters
Potential benefit: Results could lead to better prediction, prevention, and management of antibiotic allergies in patients.
How similar studies have gone: Prior work has focused on T cells and HLA; this study tests new factors and could advance the field if these ideas prove correct.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Divito, Sherrie Jill — Brigham and Women's Hospital
- Study coordinator: Divito, Sherrie Jill
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.