Positive psychology support for survivors of stem cell transplants
Official title: Positive Psychology Intervention for Hematopoietic Stem Cell Transplantation Survivors
Run by Brigham and Women's Hospital · NCT06328127 · Data updated 2026-11-12
This study is testing a new program that helps people who have had stem cell transplants feel happier and less anxious by encouraging them to do enjoyable activities.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 400 (estimated) |
| Sponsor | Brigham and Women's Hospital Academic / other |
| Locations | 3 sites (Tampa, Florida and 2 other locations) |
| Status | Recruiting |
| Started | December 17, 2024 |
| Main results expected | May 31, 2029 |
| Study ends | May 31, 2030 |
| Registry record updated | September 10, 2026 |
| Trial ID | NCT06328127 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adult patients aged 18 and older who are undergoing allogeneic HSCT and are approaching 100 days post-transplant.
✕Probably not a fit
Patients who underwent HSCT for benign conditions or those with severe psychiatric or cognitive impairments may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial evaluates the effectiveness of a positive psychology intervention called PATH on improving anxiety, depression, and quality of life in survivors of hematopoietic stem cell transplantation (HSCT). The intervention is designed for patients who are 100 days post-transplant and focuses on encouraging enjoyable activities to enhance positive emotions. Participants will be compared to a control group receiving usual care, with outcomes measured using validated assessment tools. The study aims to address the psychological needs of HSCT survivors during their recovery phase.
Why it matters
Potential benefit: If successful, this intervention could significantly improve the mental health and overall quality of life for HSCT survivors.
How similar studies have gone: Other studies have shown promising results with psychological interventions in similar patient populations, suggesting potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients (aged 18 years and older) undergoing allogeneic HSCT and are approaching 100-days post-HSCT * Ability to speak, read, and respond to questions in English or Spanish to complete study procedures * Access to a basic telephone Exclusion Criteria: * Patients who underwent allogeneic HSCT for benign hematologic conditions * Patients with severe psychiatric or cognitive conditions, such as dementia, determined by their transplant oncologist to make them unable to provide informed consent or comply with study procedures
Where it's running
-
Moffitt Cancer Center
Tampa, Florida, United States Recruiting -
Dana Farber Cancer Institute
Boston, Massachusetts, United States Recruiting -
Duke Cancer Institute
Durham, North Carolina, United States Recruiting
Study contacts
- Principal investigator: Hermioni Amonoo, MD, MPP, MPH — Brigham and Women's Hospital
- Study coordinator: Hermioni Amonoo, MD, MPP, MPH
- Email: hermioni_amonoo@dfci.harvard.edu
- Phone: 617-525-7472
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Early Cognitive Behavioral Therapy for Insomnia Before Stem Cell Transplant
This trial tests whether starting six telehealth CBT-I sessions before hematopoietic stem cell transplant can help adults with insomnia feel better and have less fatigue.
-
Coping skills training for patients after stem cell transplant
This study is testing a new coping skills program to see if it helps people who have had a stem cell transplant manage pain, fatigue, and stress better than usual care.
-
Preventing GvHD in patients with blood cancers undergoing stem cell transplants
This study is testing a new treatment called TRX-103 to see if it can help prevent graft-versus-host disease in people with blood cancers who are getting stem cell transplants from mismatched donors.
-
Program to enhance heart health in patients getting stem cell transplants
This study tests a heart health program for patients with cardiovascular risks who are getting stem cell transplants to see if it helps them get fitter and avoid heart problems.
-
T Cell Therapy for Cytomegalovirus Infections
This study is testing whether using special immune cells from donors can help patients who had a stem cell transplant fight off cytomegalovirus infections.
-
Withaferin A to help prevent graft-versus-host disease after stem cell transplant
This trial tests whether adding standardized Withaferin A to standard GvHD prevention can help people 18 and older with blood cancers who are getting a matched related donor stem cell transplant.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.