How kidney transplant affects blood flow in the heart's tiny vessels in people with advanced CKD
Official title: The Impact of Renal Transplant on Coronary Microvascular Function Among Patients With Advanced Chronic Kidney Disease
Run by Brigham and Women's Hospital · NCT07222683 · Data updated 2026-11-12
This study will try to see if getting a kidney transplant improves blood flow in the small vessels of the heart for people with advanced chronic kidney disease who are on the transplant waitlist.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | Brigham and Women's Hospital Academic / other |
| Locations | 1 site (Boston, Massachusetts) |
| Status | Recruiting |
| Started | March 10, 2023 |
| Main results expected | July 2030 |
| Study ends | July 2030 |
| Registry record updated | October 30, 2025 |
| Trial ID | NCT07222683 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults listed for kidney transplant who are age ≥45 (or 18–44 if on dialysis ≥5 years) with LVEF ≥40% and without prior CABG or heart transplant.
✕Probably not a fit
Patients with severe left ventricular dysfunction (LVEF <40%), prior CABG or heart transplant, those who require revascularization before transplant, or those who do not undergo transplant are unlikely to benefit from the study's goals.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational, pre/post transplant study that uses PET myocardial flow reserve (MFR) to measure coronary microvascular function before and after kidney transplant. The study will also measure blood markers of inflammation and dysregulated angiogenesis to link systemic changes with cardiac blood flow and function. Eligible participants are renal transplant candidates who meet age and dialysis-duration criteria and do not have severe left ventricular dysfunction or prior CABG or heart transplant. Participants receive PET scans and clinical follow-up at Brigham and Women's Hospital around the time of transplantation to compare changes over time.
Why it matters
Potential benefit: If successful, the findings could show that restoring kidney function with transplant improves coronary microvascular blood flow and potentially lowers cardiac risk, guiding follow-up and therapies.
How similar studies have gone: Prior research links CKD to coronary microvascular dysfunction and some reports suggest cardiac improvements after transplant, but prospective pre/post PET assessments like this are limited and relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Renal transplant candidate on the waitlist * Age greater or equal to 45 years, or if 18-44 years of age on dialysis for 5 years or more Exclusion Criteria: * Left ventricular ejection fraction (LVEF) \< 40% * History of coronary artery bypass grafting (CABG) * History of heart transplant * Patients who undergo revascularization as a result of pre-transplant cardiac PET
Where it's running
-
Brigham and Women's Hospital
Boston, Massachusetts, United States Recruiting
Study contacts
- Study coordinator: Daniel M Huck, MD, MPH
- Email: dhuck@bwh.harvard.edu
- Phone: 8573074000
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Cardiovascular health in children and young adults with chronic conditions
This project will see if children and young adults (ages 6-25) with chronic health conditions show early signs of aging in large and small blood vessels using noninvasive imaging and clinical tests.
-
Using Empagliflozin to Improve Outcomes in Kidney Transplant Recipients
This study is testing if the medication Empagliflozin can help improve kidney function and heart health in veterans who have received kidney transplants.
-
A nationwide registry for chronic kidney disease patients
This study is creating a detailed registry for people with chronic kidney disease, including those on dialysis or who have had a transplant, to help improve their care and support.
-
Observational look at how Kremezin works in adults with advanced chronic kidney disease
This study tests whether Kremezin helps adults with advanced kidney disease when used as part of routine care, by tracking safety and kidney function over up to 48 weeks.
-
Kidney and Heart Health in Adults with Type 2 Diabetes and CKD Treated with Semaglutide in China
This study tests whether semaglutide injections help kidney and heart health in adults with type 2 diabetes and chronic kidney disease.
-
High BMI and periodontitis in Thai adults under 60
This study tests how common high BMI and periodontitis are among Thai adults aged 18–59 and what factors are linked to them.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.