Aim to prevent diagnostic errors through hospital collaboration and teamwork
Official title: Achieving Diagnostic Excellence Through Prevention and Teamwork (ADEPT)
Run by Brigham and Women's Hospital · NCT05747755 · Data updated 2026-11-12
Hospitals will share data to see how often diagnostic errors happen and test ways to work together to reduce them for hospitalized patients.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 7200 (estimated) |
| Sponsor | Brigham and Women's Hospital Academic / other |
| Locations | 2 sites (San Francisco, California and 1 other locations) |
| Status | Recruiting |
| Started | November 14, 2023 |
| Main results expected | September 1, 2026 |
| Study ends | March 2027 |
| Registry record updated | September 8, 2026 |
| Trial ID | NCT05747755 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adult inpatients on general medicine services at participating hospitals who died in-hospital, were transferred to ICU within 48 hours, or had a rapid response.
✕Probably not a fit
Patients not experiencing the specified outcomes or those not receiving care within participating hospitals may see no direct benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This project links hospitals to measure and share diagnostic error rates, identify underlying causes, and develop collaborative approaches to reduce harms from diagnostic errors. It uses a learning health system model and rigorous adjudication to understand where errors arise and how improvements can be sustained. The program builds on the UPSIDE study within a 55-hospital HOMERuN network to define risk factors, causes, and prevalence of inpatient diagnostic errors and to test data-sharing and teamwork strategies. The ADEPT program focuses on translating findings into hospital quality-improvement efforts and resilient processes. Eligible patients are adults admitted to general medicine who experience death, ICU transfer after 48 hours, or rapid response events during hospitalization.
Why it matters
Potential benefit: If successful, patients could experience fewer diagnostic errors and related harms due to improved hospital processes and collaboration.
How similar studies have gone: Prior work with the HOMERuN network and UPSIDE has established risk factors and adjudication methods, suggesting potential for meaningful improvements.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients admitted to general medicine services at one of the participating hospitals and who either died during the hospitalization, were transferred to the ICU \>= 48 hours after admission, or had a rapid response. Exclusion Criteria: * Admitted for a non-medical reason * Patients coded in the field who are moribund on arrival to the hospital
Where it's running
-
University of California San Francisco
San Francisco, California, United States Recruiting -
Brigham & Women's Hospital
Boston, Massachusetts, United States Recruiting
Study contacts
- Principal investigator: Andrew Auerbach — University of California, San Francisco
- Study coordinator: Tiffany Lee
- Email: tiffany.lee@ucsf.edu
- Phone: 415-476-6949
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.