Computer alert to help identify and manage familial high cholesterol
Official title: Alert-Based Computerized Decision Support for Identification and Management of Patients With Familial Hypercholesterolemia (FH-ALERT Trial)
Run by Brigham and Women's Hospital · NCT06743659 · Data updated 2026-11-12
This project will test whether a computer alert in the electronic health record helps clinicians recognize and treat adults with familial hypercholesterolemia.
Quick facts
| Study type | Interventional |
|---|---|
| Sex | All |
| Enrollment | 450 (estimated) |
| Sponsor | Brigham and Women's Hospital Academic / other |
| Locations | 1 site (Boston, Massachusetts) |
| Status | Recruiting |
| Started | April 1, 2025 |
| Main results expected | March 30, 2027 |
| Study ends | November 30, 2027 |
| Registry record updated | September 29, 2026 |
| Trial ID | NCT06743659 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (≥18) seen in Brigham and Women's outpatient endocrinology, cardiology, or primary care clinics who meet a Dutch Lipid Clinic Network score of at least 3 and do not already have FH documented are ideal candidates.
✕Probably not a fit
Patients who already have an FH diagnosis, who do not receive care at the participating Brigham and Women's outpatient clinics, or who do not meet the scoring criteria are unlikely to benefit from the alert.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
FH-ALERT is a single-center, time-series trial using an EPIC Best Practice Advisory (BPA) that runs silently for 6 months and then switches to on-screen alerts for 18 months to notify clinicians about outpatients with presentations consistent with familial hypercholesterolemia (FH). The intervention is a patient- and provider-facing computerized decision support alert intended to increase FH diagnosis, lower LDL-C, and promote guideline-based therapy. Consecutive adult outpatients seen in Brigham and Women's Hospital endocrinology, cardiovascular medicine, and primary care clinics who meet a Dutch Lipid Clinic Network score threshold will be identified by the tool. Patients with a prior documented FH diagnosis in the electronic health record are excluded.
Why it matters
Potential benefit: If successful, the alert could help clinicians find more people with FH earlier and prompt treatment that lowers LDL cholesterol and reduces long-term cardiovascular risk.
How similar studies have gone: Electronic alerts and decision-support tools have shown mixed but sometimes modest success improving recognition and guideline-based care for cardiovascular risk conditions, while EHR-based approaches specifically for FH remain relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * ≥ 18 years old * seen in the BWH Endocrinology, Cardiovascular Medicine, and Primary Care Clinics * Dutch Lipid Clinic Network score of at least 3 points Exclusion Criteria: * a Familial Hypercholesterolemia diagnosis already documented in the EHR medical history, visit history, or problem list
Where it's running
-
Brigham and Women's Hospital
Boston, Massachusetts, United States Recruiting
Study contacts
- Study coordinator: Gregory Piazza, MD, MS
- Email: gpiazza@partners.org
- Phone: 6177326984
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.