Using brain stimulation to improve appetite control in Prader-Willi syndrome
Noninvasive Neuromodulation of a Novel Cerebellar Satiety Circuit in Prader-Willi Syndrome
This study tests if a brain stimulation technique can help people with Prader-Willi syndrome control their appetite and feel full.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years to 64 Years |
| Sex | All |
| Sponsor | Brigham and Women's Hospital Academic / other |
| Locations | 1 site (Belmont, Massachusetts) |
| Trial ID | NCT05938543 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of repetitive transcranial magnetic stimulation (rTMS) on hyperphagia and satiety in individuals with Prader-Willi syndrome. By applying a noninvasive magnetic field to stimulate brain activity, researchers aim to understand how this technique may help manage excessive appetite associated with the condition. Participants diagnosed with Prader-Willi syndrome will receive rTMS to assess its potential benefits in regulating hunger and satiety responses.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals diagnosed with Prader-Willi syndrome.
Not a fit: Patients with contraindications for TMS or MRI, such as a history of neurological disorders or implanted devices, may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve appetite control and quality of life for patients with Prader-Willi syndrome.
How similar studies have performed: While the use of TMS in this specific context is novel, similar studies have shown promise in using brain stimulation techniques for appetite regulation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of Prader-Willi syndrome Exclusion Criteria: * contraindications for TMS or MRI including : * history of neurological disorder * history of head trauma resulting in loss of consciousness * history of seizures or diagnosis of epilepsy or first degree relative family history of epilepsy * metal in brain or skull * implanted devices such as a pacemaker, medication pump, nerve stimulator or ventriculoperitoneal shunt claustrophobic in MRI
Where this trial is running
Belmont, Massachusetts
- McLean Hospital — Belmont, Massachusetts, United States (Recruiting)
Study contacts
- Principal investigator: Laura Holsen, PhD — Brigham and Women's Hospital
- Study coordinator: Laura Holsen, PhD
- Email: lholsen@bwh.harvard.edu
- Phone: 617-525-8772
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.