Using brain stimulation to improve appetite control in Prader-Willi syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of repetitive transcranial magnetic stimulation (rTMS) on hyperphagia and satiety in individuals with Prader-Willi syndrome. By applying a noninvasive magnetic field to stimulate brain activity, researchers aim to understand how this technique may help manage excessive appetite associated with the condition. Participants diagnosed with Prader-Willi syndrome will receive rTMS to assess its potential benefits in regulating hunger and satiety responses.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of Prader-Willi syndrome

Exclusion Criteria:

* contraindications for TMS or MRI including :
* history of neurological disorder
* history of head trauma resulting in loss of consciousness
* history of seizures or diagnosis of epilepsy or first degree relative family history of epilepsy
* metal in brain or skull
* implanted devices such as a pacemaker, medication pump, nerve stimulator or ventriculoperitoneal shunt claustrophobic in MRI

Where it's running

• McLean Hospital
  Belmont, Massachusetts, United States Recruiting

Study contacts

• Principal investigator: Laura Holsen, PhD — Brigham and Women's Hospital
• Study coordinator: Laura Holsen, PhD
• Email: lholsen@bwh.harvard.edu
• Phone: 617-525-8772

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• CSTI-500 in Prader-Willi Syndrome: a dose-escalation study for safety and efficacy

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  This study is testing if a weight loss medication called Tirzepatide can help young adults with Prader-Willi Syndrome and hypothalamic obesity lose weight and improve their health.

  Recruiting at 3 sites Phase 4 Seattle Children's Hospital · Saint Paul, Minnesota and 2 other locations · NCT06901245

• Examining autistic traits and sensory profiles in children with Prader-Willi Syndrome

  This study looks at how autistic traits and sensory experiences show up in children with Prader-Willi Syndrome to better understand their needs and see if early oxytocin treatment makes a difference.

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• Inclusive physical activity program for adults with intellectual disabilities

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• Using vagus nerve stimulation to improve emotion and thinking in Prader-Willi Syndrome

  This study is testing whether a new treatment using vagus nerve stimulation can help improve emotions and thinking skills in adults with Prader-Willi Syndrome.

  Recruiting at 3 sites University of Bordeaux · Bordeaux and 3 other locations · NCT06720571

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.