Clinical trial Recruiting at 1 site Observational Ages 18 and up

Understanding how psychological factors affect pain management in surgery

Official title: Impact of Patient Phenotypic Features on the Experience and Effectiveness of Regional Anesthesia and Postoperative Pain

Run by Brigham and Women's Hospital · NCT06466941 · Data updated 2026-11-12

This study looks at how feelings and worries about pain affect how well regional anesthesia works for people having surgery.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment1000 (estimated)
SponsorBrigham and Women's Hospital
Academic / other
Locations1 site (Boston, Massachusetts)
StatusRecruiting
StartedJuly 3, 2024
Main results expectedDecember 31, 2027
Study endsDecember 31, 2028
Registry record updatedMay 22, 2026
Trial IDNCT06466941 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include English-speaking adults aged 18 and older who are undergoing surgery and can participate in psychosocial assessments.

Probably not a fit

Patients with cognitive dysfunction that prevents effective communication may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the impact of regional anesthesia on pain management in surgical patients with varying psychosocial profiles, including anxiety and concerns about pain. Researchers will assess how these psychological factors influence the effectiveness of regional anesthesia, opioid consumption, and the development of chronic postoperative pain. By utilizing validated psychosocial surveys and semi-structured interviews, the study seeks to identify which patient phenotypes benefit most from regional anesthesia. The findings could enhance pain management strategies and improve patient outcomes in surgical settings.

Why it matters

Potential benefit: If successful, this study could lead to more personalized pain management approaches that reduce opioid use and improve recovery outcomes for surgical patients.

How similar studies have gone: Previous studies have indicated that psychosocial factors significantly influence pain outcomes, suggesting that this approach may yield valuable insights.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age ≥ 18
* English speaking
* Surgical or procedural patient who will be admitted postoperatively
* Willingness to answer psychosocial survey and/or audio recorded semi-structured interview

Exclusion Criteria:

-Cognitive dysfunction that precludes communication

Where it's running

  • Brigham and Women's Hospital
    Boston, Massachusetts, United States
    Recruiting

Study contacts

  • Principal investigator: Robert Edwards, PhD — Brigham and Women's Hospital
  • Study coordinator: Yun-Yun K Chen, MD
  • Email: ykchen@mgb.org
  • Phone: 617-651-0932

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.