Understanding how psychological factors affect pain management in surgery
Official title: Impact of Patient Phenotypic Features on the Experience and Effectiveness of Regional Anesthesia and Postoperative Pain
Run by Brigham and Women's Hospital · NCT06466941 · Data updated 2026-11-12
This study looks at how feelings and worries about pain affect how well regional anesthesia works for people having surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1000 (estimated) |
| Sponsor | Brigham and Women's Hospital Academic / other |
| Locations | 1 site (Boston, Massachusetts) |
| Status | Recruiting |
| Started | July 3, 2024 |
| Main results expected | December 31, 2027 |
| Study ends | December 31, 2028 |
| Registry record updated | May 22, 2026 |
| Trial ID | NCT06466941 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include English-speaking adults aged 18 and older who are undergoing surgery and can participate in psychosocial assessments.
✕Probably not a fit
Patients with cognitive dysfunction that prevents effective communication may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to explore the impact of regional anesthesia on pain management in surgical patients with varying psychosocial profiles, including anxiety and concerns about pain. Researchers will assess how these psychological factors influence the effectiveness of regional anesthesia, opioid consumption, and the development of chronic postoperative pain. By utilizing validated psychosocial surveys and semi-structured interviews, the study seeks to identify which patient phenotypes benefit most from regional anesthesia. The findings could enhance pain management strategies and improve patient outcomes in surgical settings.
Why it matters
Potential benefit: If successful, this study could lead to more personalized pain management approaches that reduce opioid use and improve recovery outcomes for surgical patients.
How similar studies have gone: Previous studies have indicated that psychosocial factors significantly influence pain outcomes, suggesting that this approach may yield valuable insights.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 * English speaking * Surgical or procedural patient who will be admitted postoperatively * Willingness to answer psychosocial survey and/or audio recorded semi-structured interview Exclusion Criteria: -Cognitive dysfunction that precludes communication
Where it's running
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Brigham and Women's Hospital
Boston, Massachusetts, United States Recruiting
Study contacts
- Principal investigator: Robert Edwards, PhD — Brigham and Women's Hospital
- Study coordinator: Yun-Yun K Chen, MD
- Email: ykchen@mgb.org
- Phone: 617-651-0932
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.