Testing new medications for obstructive sleep apnea
Official title: Pharmacological Activation of Hypoglossal Motor Nucleus for Obstructive Sleep Apnea Aim 2
Run by Brigham and Women's Hospital · NCT03858751 · Data updated 2026-11-12
This study is testing four new medications to see if they can help people with obstructive sleep apnea breathe better during sleep.
Quick facts
| Phase | Phase1; Phase2 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Enrollment | 16 (estimated) |
| Sponsor | Brigham and Women's Hospital Academic / other |
| Locations | 1 site (Boston, Massachusetts) |
| Status | Recruiting |
| Started | March 1, 2019 |
| Main results expected | November 30, 2022 |
| Study ends | December 31, 2022 |
| Registry record updated | September 21, 2022 |
| Trial ID | NCT03858751 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults with obstructive sleep apnea characterized by an apnea-hypopnea index (AHI) greater than 10 events per hour during NREM supine sleep.
✕Probably not a fit
Patients with severe obstructive sleep apnea, underlying cardiac disease, or those taking certain psychiatric medications may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the effects of four different medications (LTM1201AZ, LTM1201AT, LTM1201AD, LTM1201AG) on patients with obstructive sleep apnea (OSA). The study aims to determine how these medications influence upper airway muscle activity and the severity of OSA during sleep. Participants will receive either the medications or a placebo before sleep to assess their impact on OSA traits. The trial is designed to provide insights into potential new treatments for this common condition.
Why it matters
Potential benefit: If successful, this study could lead to new pharmacological treatments for obstructive sleep apnea, improving patient outcomes and quality of life.
How similar studies have gone: While there have been various approaches to treating obstructive sleep apnea, the specific pharmacological activation of upper airway muscles in this manner is relatively novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * AHI \> 10 events/h during NREM supine sleep Exclusion Criteria: * Any medical condition other than well controlled hypertension and mild diabetes. * Any medication known to influence breathing, sleep/arousal, or muscle physiology. * Claustrophobia. * Inability to sleep supine. * Allergy to any of the medications tested in the protocol. * History of kidney stones, hypercalcemia, primary hyperparathyroidism, sarcoidosis, hypervitaminosis D. * Individuals with underlying cardiac disease, such as arrhythmias. * Individuals taking psychiatric medications, such as an MAO-I, SSRI or SNRI, or any of the studied medications for medical care. * For women: Pregnancy. * Pulmonary hypertension * Severe OSA with a mean SaO2 lower than 88%
Where it's running
-
Brigham and Women's Hospital
Boston, Massachusetts, United States Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.