What makes CPPD and osteoarthritis worsen in older adults and how colchicine might help
Official title: Inflammatory Mechanisms Underlying CPPD and Osteoarthritis: Imaging and Biomarker Approaches
Funded at Brigham and Women's Hospital · NIH-11459691 · Data updated 2026-11-12
Researchers will study how inflammation and biomarkers relate to knee pain in adults with CPPD and osteoarthritis to see if daily colchicine helps.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 15, 2026 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $494,439 |
| NIH project number | 1R01AR088131-01 |
| Project ID | NIH-11459691 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults aged 21 and older with CPPD and OA who are part of or similar to the CRYSTALLIZE trial cohorts and have knee imaging findings of chondrocalcinosis.
✕Less likely to help
Patients without CPPD-related inflammation or without knee chondrocalcinosis may see little or no benefit.
What this research studies
This project builds on a large, existing trial to explore which patients with CPPD and osteoarthritis are most likely to benefit from daily colchicine, using imaging findings and blood biomarkers. By examining knee chondrocalcinosis and related inflammatory signals, the study aims to identify signatures that predict symptom or biomarker improvement after colchicine treatment over 24 weeks. The work leverages data and participants from a multicenter trial and adds biomarker analyses to understand who may respond best and why. If successful, findings could guide personalized treatment choices for older adults with CPPD and OA.
Why it matters
Potential benefit: It could help clinicians tailor colchicine treatment to those most likely to improve symptoms and inflammation in CPPD and OA.
How similar studies have gone: Previous trials have shown biomarker changes with colchicine in inflammatory conditions, but this study tests a more precise biomarker signature in CPPD+OA.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Tedeschi, Sara K. — Brigham and Women's Hospital
- Study coordinator: Tedeschi, Sara K.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.