Exploring how brain stimulation affects feelings of fullness in healthy people

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the role of the cerebellar-striatal circuit in appetite regulation using transcranial magnetic stimulation (TMS) in healthy individuals. Participants will undergo screening, MRI scans, and food intake assessments to evaluate how brain stimulation influences their response to food cues. The study aims to enhance understanding of how the cerebellum contributes to feelings of satiety and eating behavior. By manipulating brain activity, researchers hope to uncover new insights into appetite control mechanisms.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Healthy individuals aged 18 to 65
* BMI of 20-35.0 kg/m2
* Normal or corrected-to-normal vision
* Good general health
* Ability to understand and willingness to sign written informed consent document

Exclusion Criteria:

* Current and/or past medical conditions
* Current and/or past eating disorder
* On a restricted diet and/or taking weight loss medication(s)
* History of bariatric surgery
* Weight fluctuation \>3% in past 3 months
* Recent history of illicit recreational drug abuse
* Current nicotine use
* Intellectual disability
* Conditions that might result in increased risks of side effects or complications from TMS or MRI

Where it's running

• McLean Hospital
  Belmont, Massachusetts, United States Recruiting
• Brigham and Women's Hospital
  Boston, Massachusetts, United States Recruiting

Study contacts

• Principal investigator: Laura Holsen, PhD — Brigham and Women's Hospital
• Study coordinator: Laura Holsen, PhD
• Email: lholsen@bwh.harvard.edu
• Phone: 617-525-8772

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.