Botswana CASCADE Clinical Trials Site focuses on cervical cancer prevention for people living with HIV
Official title: Botswana CASCADE Clinical Trials Site
Funded at Brigham and Women's Hospital · NIH-11535389 · Data updated 2026-11-12
A national HIV-focused cancer program is testing better ways to screen for cervical precancers and treat them early so people living with HIV have fewer cancer deaths.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 5, 2022 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $234,775 |
| NIH project number | 3UG1CA275416-05S1 |
| Project ID | NIH-11535389 on NIH RePORTER |
Who could benefit from this research
✓Could help
People living with HIV who are at risk for or have experienced cervical precancer or cancer, and who are eligible for cervical cancer screening and treatment.
✕Less likely to help
Individuals without HIV or those not engaged in cervical cancer screening or treatment pathways are less likely to benefit from these specific strategies.
What this research studies
This grant supports a clinical trials site that will test practical ways to prevent cervical cancer in people with HIV, including self-collection of samples for HPV testing and screening in non-traditional settings. It will also explore how to manage positive screening results to prevent invasive cancer while using healthcare resources wisely. The project will examine access to precancer treatments, completion of therapy, and outcomes, as well as comparing different ablation techniques and vaccination or immunologic options. By working in diverse care settings, the site aims to translate successful screening and treatment strategies into real-world care for people living with HIV in Botswana and similar contexts.
Why it matters
Potential benefit: If successful, these strategies could reduce cervical cancer deaths among people with HIV by enabling earlier detection and more effective, accessible treatment.
How similar studies have gone: Previous studies show that alternative screening methods and streamlined treatment pathways can improve precancer detection and outcomes in high-risk populations.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Dryden-Peterson, Scott — Brigham and Women's Hospital
- Study coordinator: Dryden-Peterson, Scott
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.