Clinical trial Recruiting at 1 site Interventional Ages 40 to 75

Using AI to detect coronary artery calcium for better heart disease prevention

Official title: AI Detection of Incidental Coronary Artery Calcium to Enhance Cardiovascular Disease Prevention: A Multicenter Randomized Trial

Run by Brigham and Women's Hospital · NCT06235112 · Data updated 2026-11-12

This study tests if using an AI tool to spot calcium buildup in heart arteries can help doctors provide better preventive care for patients at risk of heart disease.

More Coronary Artery Disease trials

Quick facts

Study typeInterventional
Ages40 Years to 75 Years
SexAll
Enrollment1500 (estimated)
SponsorBrigham and Women's Hospital
Academic / other
Locations1 site (Boston, Massachusetts)
StatusRecruiting
StartedJuly 31, 2024
Main results expectedJune 1, 2027
Study endsDecember 1, 2027
Registry record updatedJanuary 23, 2026
Trial IDNCT06235112 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are individuals aged 40-75 who have had a chest CT scan within the last three years.

Probably not a fit

Patients with a history of coronary artery disease, cancer, or other life-limiting conditions may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial aims to evaluate whether informing clinicians about the presence and quantity of coronary artery calcifications (CAC) through an AI platform can lead to improved preventive care for patients at risk of cardiovascular disease. The study will utilize a cloud-based AI system that analyzes non-contrast chest CT scans to assess CAC levels. By providing this information, the trial seeks to encourage the initiation or intensification of preventive therapies among eligible patients. It is a multicenter randomized trial involving Brigham and Women's Hospital and other locations.

Why it matters

Potential benefit: If successful, this approach could significantly enhance cardiovascular disease prevention strategies for at-risk patients.

How similar studies have gone: Other studies have shown promise in using AI for medical imaging analysis, suggesting potential success for this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients aged between 40-75 with prior chest CT within last 3 years

Exclusion Criteria:

* Prior coronary artery disease
* Prior cancer
* Other life-limiting condition

Where it's running

  • Brigham and Women's Hospital
    Boston, Massachusetts, United States
    Recruiting

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.