Acceptance and Commitment Therapy to reduce disability in adults with chronic migraine

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with chronic migraine who are followed at the Graham Headache Center will be randomized to receive eight ACT classes plus home practice in addition to their regular headache treatment or to continue their regular treatment without ACT. Participants will complete daily headache diaries and take part in four virtual visits over the following year to report symptoms and functioning. The trial focuses on disability and daily functioning questionnaires as primary outcomes, alongside measures of headache frequency and pain. Patients with major psychiatric conditions, recent psychotherapy, non-English speakers, or prior mindfulness experience are excluded and participants must have access to the required technology.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Willingness and ability to engage in the consent process
* Willingness to participate in the study, despite randomization outcome
* Availability for the duration of the study
* Diagnosis of chronic migraine followed at the Graham Headache Center
* Access to the necessary resources for participating in a technology-based intervention

Exclusion Criteria:

* Known major depression or other psychiatric condition
* Non-English speaking
* Secondary headache diagnosis
* Psychotherapy in the prior 18 months
* Any reason the provider feels would limit participant ability to learn or practice ACT
* Any previous experience with mindfulness or meditation approaches

Where it's running

• Brigham and Women's / Faulkner Hospital
  Boston, Massachusetts, United States Recruiting

Study contacts

• Study coordinator: Paul Rizzoli, MD
• Email: prizzoli@bwh.harvard.edu
• Phone: 617 983 7580

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Nebulized dexmedetomidine for early chronic migraine

  This study tests whether inhaled dexmedetomidine can lessen central sensitization and help prevent chronification in people with early chronic migraine.

  Recruiting Beni-Suef University · Banī Suwayf · NCT07769255

• i-NEED: New migraine drugs database

  This project will collect real-life data to see how new migraine treatments—anti‑CGRP antibodies, gepants, ditans, and a sumatriptan‑naproxen combo—work and how well adults with episodic or chronic migraine tolerate them.

  Recruiting at 2 sites IRCCS San Raffaele Roma · Milan, Italy and 1 other locations · NCT07103694

• Suppressive Functions of Regulatory T Cells in Migraine

  This study tests whether regulatory T cells can help control migraine-related inflammation in adults with chronic migraine.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand · NCT07067112

• Comparing sphenopalatine block and BOTOX for chronic migraine relief

  This study is testing whether a nerve block or BOTOX injections can help people with chronic migraines feel better.

  Recruiting Cairo University · Cairo · NCT06974617

• Using Atogepant tablets to prevent migraines in teens aged 12 to 17

  This study is testing if Atogepant tablets can help prevent migraines in teenagers aged 12 to 17.

  Recruiting at 61 sites Phase 3 AbbVie · Huntsville, Alabama and 65 other locations · NCT06810505

• Comparing nerve block injections to Botox for chronic migraine relief

  This study tests whether nerve block injections or Botox can help adults with chronic migraines feel better and have fewer migraine days.

  Recruiting Zagazig University · Zagazig, Sharqia Province · NCT06684249

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.