Multicenter stress cardiac MRI measuring heart muscle blood flow

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter study will enroll adults with chest pain or abnormal ECGs and intermediate-to-high risk features and perform standardized quantitative stress cardiac MRI across participating U.S. centers. Each participant will undergo vasodilator stress (regadenoson or adenosine) with gadolinium-based contrast (Gadavist 0.05 mmol/kg for stress and 0.05 mmol/kg for rest) to generate quantitative myocardial blood flow and flow reserve measurements alongside routine qualitative perfusion imaging. Investigators will compare quantitative perfusion indices to qualitative imaging and clinical risk factors to see whether abnormal blood-flow measurements predict higher rates of adverse cardiac events and better characterize multivessel disease. Results will be used to determine whether quantitative perfusion should influence decisions about invasive testing or early targeted medical therapy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. male or female at age 35-85 years,
2. presence of either of the following sign/symptom that led to a referral to stress cardiac magnetic resonance imaging:

   1. chest pain or anginal equivalent, or
   2. abnormal electrocardiogram with a suspicion of coronary artery disease
3. Intermediate or high risk of significant coronary disease based on at least 1 of the following conditions:

   a) patient age \> 45 for male, 50 for female b) Diabetes, hypertension, or hypercholesterolemia: by either history or medical treatment c) family history of premature coronary disease: first degree relative at age \<= 55 male and \<=65 female d) history of smoking of \> 10 packed-years e) post-menopausal state \>5 years f) any chronic inflammatory conditions d) Body mass index \> 30 e) Any medical documentation of coronary or peripheral artery disease

Exclusion Criteria:

1. Acute myocardial infarction within the past 30 days prior to cardiac magnetic resonance imaging
2. Confirmed diagnosis of any significant non-coronary cardiac conditions below:

   1. any severe-grade valvular heart disease,
   2. left ventricular ejection fraction \<40% from any known non-coronary causes,
   3. infiltrative cardiomyopathy,
   4. hypertrophic cardiomyopathy,
   5. pericardial disease with significant constriction, or
3. active pregnancy,
4. any competing conditions leading to an expected survival of \< 2 years
5. contraindication to vasodilator (regadenoson or adenosine)
6. metallic device or object that poses an magnetic resonance imaging safety hazard
7. metallic device with a high likelihood of non-diagnostic cardiac magnetic resonance images

Where it's running

• University of California San Francisco
  San Francisco, California, United States Recruiting
• UofL Health - Heart Hospital
  Louisville, Kentucky, United States Recruiting
• Brigham and Women's Hospital
  Boston, Massachusetts, United States Recruiting
• Beth Israel Deaconess Medical Center
  Boston, Massachusetts, United States Recruiting
• St. Francis Hospital and Heart Center
  Roslyn, New York, United States Recruiting
• Atrium Health - Sanger Heart & Vascular Institute
  Charlotte, North Carolina, United States Recruiting

Study contacts

• Study coordinator: Raymond Y Kwong, MD, MPH
• Email: rykwong@bwh.harvard.edu
• Phone: 857-307-1960

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Multimodal regional nerve blocks to improve recovery after off-pump CABG

  This study tests whether using multiple regional nerve blocks can reduce pain and help patients recover after off-pump coronary artery bypass surgery.

  Recruiting Ain Shams University · Cairo · NCT07794527

• Revascularization of Calcified Coronary Arteries

  This study tests whether measuring blood flow and pressure before and after ballooning or stenting of calcified coronary arteries can help predict how well the procedure will work for adults with heart disease.

  Recruiting Aalborg University Hospital · Aalborg · NCT07724184

• 4D MRI parameters linked to cardiovascular and cancer disease outcomes

  This study tests whether 4D MRI measurements can predict how cardiovascular diseases and cancer will progress in adults undergoing routine cardiac MRI at a single Korean hospital.

  Recruiting Ulsan University Hospital · Ulsan, Ulsan · NCT07678606

• Multimodal Cardiac MRI to See How the Heart Is Working

  This study tests a comprehensive MRI approach to characterize heart structure and tissue in adults with suspected or confirmed cardiovascular disease.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07617844

• Personalized online psychological program for people with ischemic heart disease and anxiety or depression

  This project will test a personalized, therapist-supported online program to see if it helps adults with ischemic heart disease who have anxiety or depression.

  Recruiting at 3 sites University of Southern Denmark · Aalborg and 2 other locations · NCT07569458

• FAPI PET/CT imaging in arrhythmogenic right ventricular cardiomyopathy

  This study will test whether a PET/CT scan using a 68Ga-DOTA-SA-FAPI tracer can detect active scarring in adults with ARVC and provide information beyond standard heart imaging.

  Recruiting Istanbul University - Cerrahpasa · Istanbul, Fatih · NCT07563660

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.