Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Using computerized alerts to improve cholesterol treatment in patients with Peripheral Artery Disease

Official title: Randomized Controlled Trial of Alert-Based Computerized Decision Support for Patients With Peripheral Artery Disease Not Prescribed Lipid-Lowering Therapy

Run by Brigham and Women's Hospital · NCT06300450 · Data updated 2026-11-12

This study is testing a new computer alert system to see if it can help doctors prescribe cholesterol-lowering medications more often for patients with Peripheral Artery Disease who aren't currently on them.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment400 (estimated)
SponsorBrigham and Women's Hospital
Academic / other
Locations1 site (Boston, Massachusetts)
StatusRecruiting
StartedMarch 1, 2023
Main results expectedDecember 28, 2026
Study endsDecember 30, 2026
Registry record updatedJune 17, 2026
Trial IDNCT06300450 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults aged 18 and older with a diagnosis of Peripheral Artery Disease who are not currently prescribed any LDL-C-lowering therapy.

Probably not a fit

Patients who are already taking LDL-C-lowering medications such as statins or ezetimibe will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the effectiveness of an alert-based computerized decision support tool, known as EPIC Best Practice Advisory (BPA), in increasing the prescription of LDL-C-lowering therapies among patients with Peripheral Artery Disease (PAD) who are currently not receiving such treatments. The study involves 400 patients and aims to address the underutilization of guideline-directed therapies by providing timely alerts to both patients and healthcare providers. The trial is conducted at a single center, Brigham and Women's Hospital, and focuses on improving adherence to clinical guidelines for managing cholesterol levels in PAD patients.

Why it matters

Potential benefit: If successful, this approach could significantly enhance the management of cholesterol levels in patients with PAD, potentially reducing cardiovascular risks.

How similar studies have gone: Previous studies have indicated that computerized decision support tools can improve adherence to treatment guidelines, suggesting potential success for this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* All patients ≥ 18 years old
* Seen in Cardiovascular Medicine Clinic, Primary Care, Podiatry, Vascular Surgery, and Diabetology
* Medical history entry, visit diagnosis, or problem list entry of PAD
* Not prescribed LDL-C-lowering therapy

Exclusion Criteria:

* Patients taking a statin, ezetimibe, bempedoic acid, a PCSK9 inhibitor, inclisiran or a combination will be excluded

Where it's running

  • Brigham and Women's Hospital
    Boston, Massachusetts, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.