Using computerized alerts to improve cholesterol treatment in patients with Peripheral Artery Disease
Randomized Controlled Trial of Alert-Based Computerized Decision Support for Patients With Peripheral Artery Disease Not Prescribed Lipid-Lowering Therapy
This study is testing a new computer alert system to see if it can help doctors prescribe cholesterol-lowering medications more often for patients with Peripheral Artery Disease who aren't currently on them.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 400 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Brigham and Women's Hospital Academic / other |
| Locations | 1 site (Boston, Massachusetts) |
| Trial ID | NCT06300450 on ClinicalTrials.gov |
What this trial studies
This clinical trial evaluates the effectiveness of an alert-based computerized decision support tool, known as EPIC Best Practice Advisory (BPA), in increasing the prescription of LDL-C-lowering therapies among patients with Peripheral Artery Disease (PAD) who are currently not receiving such treatments. The study involves 400 patients and aims to address the underutilization of guideline-directed therapies by providing timely alerts to both patients and healthcare providers. The trial is conducted at a single center, Brigham and Women's Hospital, and focuses on improving adherence to clinical guidelines for managing cholesterol levels in PAD patients.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older with a diagnosis of Peripheral Artery Disease who are not currently prescribed any LDL-C-lowering therapy.
Not a fit: Patients who are already taking LDL-C-lowering medications such as statins or ezetimibe will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly enhance the management of cholesterol levels in patients with PAD, potentially reducing cardiovascular risks.
How similar studies have performed: Previous studies have indicated that computerized decision support tools can improve adherence to treatment guidelines, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All patients ≥ 18 years old * Seen in Cardiovascular Medicine Clinic, Primary Care, Podiatry, Vascular Surgery, and Diabetology * Medical history entry, visit diagnosis, or problem list entry of PAD * Not prescribed LDL-C-lowering therapy Exclusion Criteria: * Patients taking a statin, ezetimibe, bempedoic acid, a PCSK9 inhibitor, inclisiran or a combination will be excluded
Where this trial is running
Boston, Massachusetts
- Brigham and Women's Hospital — Boston, Massachusetts, United States (Recruiting)
Study contacts
- Principal investigator: Gregory Piazza — Bwh
- Study coordinator: Gregory Piazza
- Email: gpiazza@bwh.harvard.edu
- Phone: 6177326984
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.