Understanding how physical activity affects heart and metabolic health
Effect of Physical Activity Pattern on Cardiometabolic Health
NA · Brigham and Women's Hospital · NCT05838508
This study is testing how our body's internal clock affects the benefits of exercise on heart health and metabolism to help create better workout guidelines.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 26 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | All |
| Sponsor | Brigham and Women's Hospital (other) |
| Locations | 1 site (Boston, Massachusetts) |
| Trial ID | NCT05838508 on ClinicalTrials.gov |
What this trial studies
This study investigates the relationship between the body's internal clock and physical activity patterns to enhance health benefits. Participants will undergo two inpatient stays where they will engage in moderate exercise, consume identical meals, and provide various biological samples. The research aims to determine how the circadian system influences blood glucose levels, blood pressure, and overall energy expenditure in relation to physical activity. By understanding this interaction, the study seeks to optimize exercise recommendations for better cardiometabolic health outcomes.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-45 with a BMI between 25-34.9 who are generally healthy and can adhere to the study protocol.
Not a fit: Patients with acute or chronic medical conditions, those unable to exercise, or individuals with a history of substance dependency or psychiatric disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved exercise guidelines that enhance cardiovascular and metabolic health.
How similar studies have performed: While the interaction between circadian rhythms and physical activity is a growing area of interest, this specific approach is relatively novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18-45 yr old * Body mass index (BMI) 18.5 - 34.9 kg/m2 * No acute, chronic or debilitating medical conditions (e.g. metabolic, cardiovascular, respiratory, neurological, cancers, etc.) * Willing to adhere to the protocol requirements for the duration of the study Exclusion Criteria: * Currently smoking/vaping or 5 or more years of smoking/vaping * Currently pregnant or breastfeeding * History of drug or alcohol dependency * History of psychiatric illness or disorder * Any hospitalization due to COVID-19 * Inability to exercise for any reason * Any known contraindication to exercise testing based on current ACSM guidelines
Where this trial is running
Boston, Massachusetts
- Brigham and Women's Hospital — Boston, Massachusetts, United States (RECRUITING)
Study contacts
- Principal investigator: Jingyi Qian, PhD — Brigham and Women's Hospital
- Study coordinator: Jingyi Qian, PhD
- Email: jqian@bwh.harvard.edu
- Phone: 6175257423
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Life Style, exercise, circadian system, physical activity, glucose tolerance, blood pressure