Understanding how physical activity affects heart and metabolic health

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the relationship between the body's internal clock and physical activity patterns to enhance health benefits. Participants will undergo two inpatient stays where they will engage in moderate exercise, consume identical meals, and provide various biological samples. The research aims to determine how the circadian system influences blood glucose levels, blood pressure, and overall energy expenditure in relation to physical activity. By understanding this interaction, the study seeks to optimize exercise recommendations for better cardiometabolic health outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18-45 yr old
* Body mass index (BMI) 18.5 - 34.9 kg/m2
* No acute, chronic or debilitating medical conditions (e.g. metabolic, cardiovascular, respiratory, neurological, cancers, etc.)
* Willing to adhere to the protocol requirements for the duration of the study

Exclusion Criteria:

* Currently smoking/vaping or 5 or more years of smoking/vaping
* Currently pregnant or breastfeeding
* History of drug or alcohol dependency
* History of psychiatric illness or disorder
* Any hospitalization due to COVID-19
* Inability to exercise for any reason
* Any known contraindication to exercise testing based on current ACSM guidelines

Where it's running

• Brigham and Women's Hospital
  Boston, Massachusetts, United States Recruiting

Study contacts

• Principal investigator: Jingyi Qian, PhD — Brigham and Women's Hospital
• Study coordinator: Jingyi Qian, PhD
• Email: jqian@bwh.harvard.edu
• Phone: 6175257423

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.